Practical Hematopoietic Stem Cell Transplantation

by Cant, Andrew J.; Galloway, Angela; Jackson, Graham

• ISBN13: 9781405134019
• ISBN10: 1405134011
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-01-16
• Publisher: Wiley-Blackwell

Summary

SUBJECT: Bone marrow transplantation was first successfully carried out in the 1960s and was initially performed for the treatment of acute leukeamia. However, bone marrow transplantation is now performed for a wide range of conditions including inherited bone marrow disorders such as severe combined immunodeficiency, chronic granulomatous disease and osteopetrosis as well as malignant bone marrow disorders including leukemia and myeloma. Transplantation may take the form of whole marrow from an unrelated donor or stem cells mobilised from the patient''s own bone marrow. More recently transplants from cord blood have also been used as a source of haematopietic stem cells.NEED: In this field, a range of paediatric and adult bone marrow transplanations are performed for a wide variety of disorders. The underlying condition of the patients and the immuno suppression used in bone marrow transplantation predispose the patients to a wide range of infections. In addition, other complications may arise as a result of transplantation, particularly graft versus host disease which requires a careful balance between suppressing the condition and trying to reduce the risk of infection at the same time.The management of patients requiring bone marrow and stem cell transplantation involves the input of large numbers of health care professionals and there is now a need for a practical, concise manual to guide all those working in this field. This book will be an essential guide for all major transplant units and for all members of the transplant team.FORMAT:The idea is for the book to look and feel like Practical Transfusion Medicine by Murphy. It will have a double-column design and the emphasis throughout will be on its use as a practical manual.The authors have provided a detailed breakdown of contents. Please ask if you''d like further details.AUTHOR TEAM:Co-editorsProfessor Andrew Cant BSc MB BS MD FRCP FRCPCHProfessor in Paediatric Immunology and Infectious Diseases,Director of Paediatric Bone Marrow Transplant UnitNewcastle General HospitalDr Angela Galloway BSc MB BS MD FRCPathConsultant MicrobiologistRoyal Victoria Infirmary, Newcastle upon TyneDr Graham Jackson BA MB BS MD FRCPathConsultant HaematologistDirector of the Adult Bone Marrow Transplant UnitRoyal Victoria Infirmary, Newcastle upon TyneContributorsDr Mario Abinun, Consultant in Paediatric Immunology & Infectious Diseases, Newcastle General HospitalMaggie Allan, Social Worker, Newcastle General HospitalDr Dawn Barge, BMS, Immunology Laboratory, Royal Victoria Infirmary, Newcastle upon TyneDr Arpita Bhattacharya, Associate Specialist in Paediatric Bone Marrow Transplantation, Newcastle General HospitalDr Jim CavetSenior Lecturer/Honorary Consultant in Haematology, Christies Hospital, ManchesterCarole Charley, BMT Nurse Co-ordinator/Quality ManagerChair EBMT (UK) NAP Group, Royal Hallamshire Hospital, SheffieldDr Charles Craddock, Consultant Haematologist, Queen Elizabeth Hospital, BirminghamDr Terry Flood, Consultant in Paediatric Immunology & Infectious Diseases, Newcastle General HospitalDr Alistair Gascoigne, Consultant in Respiratory Medicine & Intensive Care, Royal Victoria Infirmary, Newcastle upon TyneDr Barbara Fulton, Consultant Anaesthetist, Paediatric Intensive Care Unit, Newcastle General HospitalStephen Fox, Bone Marrow Transplant Co-ordinator Royal Victoria Infirmary, Newcastle upon TyneDr Andy Gennery, Senior Lecturer/Honorary Consultant in Paediatric Immunology, Newcastle General HospitalDot Holder, Social Worker, Royal Victoria Infirmary.Newcastle upon TyneWendy Larmouth, Sister, Paediatric Bone Marrow Transplant Unit, Newcastle General HospitalHelen Harvey, Senior Nurse, Paediatric Bone Marrow Transplant Unit, Newcastle General HospitalDr Anne Lennard, Consultant Haematologist, Royal Victoria Infirmary, Newcastle upon TyneCarol Richardson, Bone Marrow Transplant Co-ordinator, Bone Marrow Transplant Unit, Royal Victoria Infirmary, Newcastle upon TyneDr Rod Ski

Author Biography

Andrew J. Cant, BSc, MD, FRCP FRCPCH, Professor in Paediatric Immunology and Infectious Diseases, Newcastle General Hospital, Newcastle upon Tyne, UK

Angela Galloway, MD, FRCPath, Consultant Microbiologist, Royal Victoria Infirmary, Newcastle upon Tyne, UK

Graham Jackson, MD, FRCPath, Consultant Haematologist, Royal Victoria Infirmary, Newcastle upon Tyne, UK

Table of Contents

List of contributors	p. vii
Preface	p. ix
Acknowledgments	p. xi
List of abbreviations	p. xiii
Why hematopoietic stem cell transplantation and for whom?	p. 1
Pre-transplant assessment	p. 4
The transplant	p. 23
Care of the transplant patient	p. 41
Prevention of infection during hematopoietic stem cell transplantation	p. 55
Bacterial, fungal, and parasitic infections in the transplant patient	p. 67
Virus infections in the HSCT patient	p. 81
Management of febrile neutropenia and system-specific infections	p. 92
The role of intensive care in the management of hematopoietic stem cell patients	p. 108
Graft-vs.-host disease and post-transplant lymphoproliferative disease	p. 117
Gastrointestinal, respiratory and renal/urogenital complications of HSCT	p. 126
Follow up in the first year after hematopoietic stem cell transplantation	p. 133
Immune recovery following hematopoietic stem cell transplantation and vaccination	p. 140
Prevention of infection following discharge after hematopoietic stem cell transplant	p. 147
Social and psychological aspects of care	p. 158
Long-term follow up of transplant recipients	p. 174
Hematopoietic stem cell transplantation - the future	p. 188
Index	p. 193
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