Process Analytical Technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries

by Editor: Katherine A. Bakeev

• ISBN13: 9781405173193
• ISBN10: 140517319X
• Format: eBook
• Copyright: 2008-04-01
• Publisher: Wiley-Blackwell

Summary

The use of real or near real time measurement of chemical production process parameters as the basis for achieving control or optimisation of a manufacturing process has wide application in the petrochemical, food and chemical industries. Process analytical chemistry (PAC), or process analytical technology (PAT) as it has recently been called, is now being deployed in the pharmaceutical industry, where it is seen as a technology that can help companies to improve their conformity with manufacturing compliance regulations. The objective of this book is to provide a starting point for implementing process analytical chemistry tools in process monitoring applications or as part of a total quality management system. Written from the perspective of the spectroscopist required to implant PAT tools in a process environment, attention is focussed on measurements that are made "in process" at-line or off-line, providing data on product during manufacture. With chapters covering the key spectroscopic tools, their applications in the pharmaceutical and chemical industries and basic chemometrics, the novice can quickly develop a sound understanding of the most practical technologies and applications. Implementation strategies are fully covered and address some of the critical issues that need to be tackled when setting up a PAT project - including choosing a project with a sound business justification in the first place.

Table of Contents

Contributors

Preface

List of Abbreviations

Process Analytical Chemistry: Introduction and Historical Prespective

Implementation of Process Analytical Technologies

Merck and Co., Inc

Near-Infrared Spectroscopy for Process Analytical Chemistry: Theory, Technology and Implementation

ABB Analytical and Advanced Solutions

Infrared Spectroscopy for Process Analytical Applications

Coates Consulting

Process Raman Spectroscopy

General Electric, Advanced Materials

UV-Vis for On-Line Analysis

Equitech International Corporation

Near-Infrared Chemical Imaging as a Process Analytical Tool

Spectral Dimensions

Chemometrics in Process Analyical Chemistry

Dupont Engineering Technologies

On-Line Applications in the Pharmaceutical Industry

Eli Lilly and Company

Use of Near-Infrared Spectroscopy for Off-Line Measurements in the Pharmaceutical Industry

Autonomous University of Barcelona

Applications of Near-Infrared Spectroscopy (NIR) in the Chemical Industry

Future Trends in Process Analytical Chemistry

Index

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