Proteases in Gastrointestinal Tissues

by Lendeckel, Uwe; Hooper, Nigel M.

• ISBN13: 9781402044823
• ISBN10: 1402044828
• Format: Hardcover
• Copyright: 2006-05-16
• Publisher: Springer Verlag

Summary

This book is unique for its comprehensive presentation of protease function in stomach, colon, pancreas and liver under both physiological conditions and major diseases manifesting in these four organs. The individual chapters have been written by leaders in the field who paid much attention to outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Available animal models (of disease, transgenic, or knock-out) are extensively referred to and experimental data obtained thereby are discussed in the context of patient-derived data. Newcomers to the field and interested non-specialists will take advantage of the extensive introduction to individual proteases, protease families, and the diseases. Understanding is greatly facilitated by the clear and condensed presentation of summarised data in tables and graphs. This book is a valuable source for both clinicians and basic and clinical researchers interested in protease function and/or diseases in gastrointestinal tissues.

Table of Contents

Contributing Authors	vii
Preface	xv
Chapter 1 Protease-Activated Receptors in Gastrointestinal Function and Disease	1	(32)
Nigel W. Bunnett and Graeme S. Cottrell
Chapter 2 Matrix Metalloproteinases in Gastric Cancer	33	(28)
Nikhil I. Khushalani and Nithya Ramnath
Chapter 3 Proteases in Helicobacter pylori-Mediated Diseases	61	(28)
Thomas Wex, Michael Zack, and Peter Malfertheiner
Chapter 4 Proteases in Pancreatic Disease	89	(34)
Avinash Sewpaul, Jeremy J. French, and Richard M. Charnley
Chapter 5 PAR in the Pathogenesis of Pain in Pancreatic Disease	123	(8)
Pankaj J. Pasricha
Chapter 6 Importance of the Local Renin-Angiotensin System in Pancreatic Disease	131	(22)
Po Sing Leung
Chapter 7 Hepatitis C Viral Proteases And Inhibitors	153	(30)
Mingjun Huang, Avinash Phadke and Atul Agarwal
Chapter 8 Angiotensin Converting Enzyme in the Pathophysiology of Liver Fibrosis	183	(26)
Yao Hong Wei
Chapter 9 Matrix Metalloproteinases in Chronic Liver Disease and Liver Transplantation	209	(26)
Hein W. Verspaget, Johan P. Kuyvenhoven, Cornelis F. M Sier, Bart van Hoek
Chapter 10 MMPs and ADAMs in Inflammatory Bowel Disease	235	(20)
Alicja Wiercinska-Drapalo, Jerzy Jaroszewicz, Anna Parfieniuk, Anna Moniuszko
Chapter 11 Chemokines and Matrix Metalloproteinases in Colorectal Cancer	255	(46)
Gayle G. Vaday and Stanley Zucker
Chapter 12 Angiotensin-Converting Enzyme (ACE) in Gut Inflammation	301	(14)
Fernando Magro
Chapter 13 Intestinal Apical Protein Transport in Health and Disease	315	(24)
Stephan von Hörsten, Michael Krahn, Nadine Frerker, Anja Gemeinhardt, Dennis Schwab, Silvia Slesiona, Hassan Nairn, and Marwan Alfalah
Index	339