9781420078060

Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes

by ;
  • ISBN13:

    9781420078060

  • ISBN10:

    1420078062

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2009-10-19
  • Publisher: CRC Press

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Supplemental Materials

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  • The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.
  • The Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.

Summary

Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism.Key features include:

Table of Contents

1. Overview of Pharmacokinetics and Pharmacodynamics Issues for Protein and Peptide Therapeutics. 2. Metabolic Processes Affecting Protein and Peptide Therapeutics. 3. Protein and Peptide Actions and Interactions that Alter their Pharmacokinetics, Pharmacodynamics and Metabolism. 4. Inter-Species Aspects of Pharmacokinetics, Pharmacodynamics and Metabolism Measurement. 5. In Vitro/ In Vivo Correlations of Pharmacokinetics, Pharmacodynamics and Metabolism for Cytokines. 6. In Vitro/ In Vivo Correlations of Pharmacokinetics, Pharmacodynamics and Metabolism for Extracellular Matrix-binding Growth Factors. 7. In Vitro/ In Vivo Correlations of Pharmacokinetics, Pharmacodynamics and Metabolism for Hematologic Growth Factors. 8. In Vitro/ In Vivo Correlations of Pharmacokinetics, Pharmacodynamics and Metabolism for Antibody Therapeutics. 9. Engineering as a Means to Alter the Pharmacokinetics, Pharmacodynamics and Metabolism of Injected Protein and Peptide Therapeutics Peptides. 10. Local Tissue Responses to Polymer Implants Affecting Pharmacokinetics, Pharmacodynamics and Metabolism of Proteins and Peptides. 11. Ophthalmic Delivery of Protein and Peptide Therapeutics; Pharmacokinetics, Pharmacodynamics and Metabolism Considerations. 12. Pulmonary Delivery of Protein and Peptide Therapeutics; PK/PD Considerations. 13. Oral Delivery of Protein and Peptide Therapeutics; PK/PD considerations. 14. Transdermal and Intradermal Delivery of Protein and Peptide Therapeutics; PK/PD considerations. 15. Intranasal Delivery of Protein and Peptide Therapeutics; PK/PD Considerations. 16. Considerations for Protein and Peptide Therapeutics and the Elderly. 17. Intersection of Pharmacogenetics with Pharmacokinetics and Pharmacodynamics.

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