Pyridines: From Lab to Production

by Scriven

• ISBN13: 9780123852359
• ISBN10: 0123852358
• Format: Hardcover
• Copyright: 2013-02-28
• Publisher: Elsevier Science

Summary

Provides a synthetic armory of tools to aid the practicing chemist by reviewing the most reliable historical methods alongside new methods/ Written by scientists who have actually used these in synthesis. By emphasizing tricks and tips to optimize reactions for the best yields and purity, which are often missing from the primary literature, this book provides another dimension for the synthetic chemist. A combined academic and industrial approach evaluates the best methods for different scales of reaction and discusses practical tips (e.g. when to stop a reaction early to maximize purity or when to re-use side products). Chapters also assess whether to make or source starting materials, how to connect them and what are the best synthetic routes. The book is designed to be a stand-alone reference, but also provides cross references to leading reviews and the Comprehensive Heterocyclic Chemistry reference works for those who want to learn more. Reviews tried and tested practical methods to help the reader select the best method for their research Includes tips, tricks and hints to enable the reader to get the best yield or cleanest product out of their reaction for synthesising or transforming a pyridine derivative Written by both academic researchers and industry leaders this provides a unique view of how to get the most out of a reaction no matter what scale you are running this on

Table of Contents

Introduction

Ring synthesis

Attachment at ring positions

Substituent modifications and cyclizations

Formation of completely or partially reduced pyridines and quinolines

Applications to alkaloid synthesis

Fluoropyridines

Pyridine reagents

Application of Flow Reactors in Pyridine Synthesis

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