Rapidly Progressive Glomerulonephritis

by Pusey, Charles D.; Rees, Andrew J.

• ISBN13: 9780192626363
• ISBN10: 0192626361
• Format: Hardcover
• Copyright: 1998-06-04
• Publisher: Oxford University Press

Summary

Rapidly Progressive Glomerulonephritis is one of the most exciting areas in renal medicine. The disease usually presents acutely, and leads to end stage renal failure in weeks or months if untreated. However, appropriate immunosuppressive therapy can dramatically improve the prognosis in manycases, such that renal failure is avoided. It is now clear that various immunopathological processes are involved, and that an accurate diagnosis is of value in guiding management. This volume aims to bring together current knowledge of both scientific and clinical aspects of RPN. Recent advancesin the immunology, inflammatory mechanisms and pathology of RPGN are discussed. This is followed by consideration of the major causes of RPGN, which include Goodpasture's disease, primary systemic vasculitis and systemic lupus erythematosus. RPGN secondary to other renal and systemic diseases, andRPGN in children are also described. Finally, new approaches to treatment are reviewed. Although certain of these areas are covered in the larger textbooks of renal medicine, our aim is to provide a current overview of RPGN, in a concise volume. This should be of particular interest tonephrologists and general physicians, including those in training, but may also be of value to pathologists, immunologists, and other studying the mechanisms of renal disease. We hope that this volume will help them in the management of patients with RPGN, or in planning their research into thiscondition.

Table of Contents

List of contributors	ix
1 Historical background and concepts in rapidly progressive glomerulonephritis	1	(11)
Andrew J. Rees
Charles D. Pusey
2 Immunopathogenesis of crescentic glomerulonephritis	12	(31)
Stephen R. Holdsworth
Jonathan H. Erlich
Peter G. Tipping
3 Rapidly progressive glomerulonephritis: resolution and scarring	43	(16)
Roger C. Wiggins
4 Pathology of rapidly progressive glomerulonephritis	59	(49)
Franco Ferrario
Maria Pia Rastaldi
5 Anti-glomerular basement membrane disease	108	(17)
A. Neil Turner
Andrew J. Rees
6 Pathogenesis of systemic vascultis	125	(23)
Patrick Nachman
J. Charles Jennett
Ronald J. Falk
7 Clinical aspects of systemic vasculitis	148	(38)
Gillian Gaskin
Charles D. Pusey
8 Crescentic nephritis in systemic lupus erythematosus	186	(21)
Howard A. Austin III
Dimitrious T. Boumpas
James E. Balow
9 Crescentic nephritis secondary to infection, systemic disease and other glomerulopathies	207	(29)
J. Stewart Cameron
10 Rapidly progressive glomerulonephritis in children	236	(11)
Michael J. Dillon
11 Novel treatment strategies in rapidly progressive glomerulonephritis	247	(23)
Peter W. Mathieson
C. Martin Lockwood
Index	270