Receptor and Ion-Channel Trafficking Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels

by Moss, Stephen; Henley, Jeremy

• ISBN13: 9780192632241
• ISBN10: 0192632248
• Format: Hardcover
• Copyright: 2002-09-26
• Publisher: Oxford University Press

Summary

A volume in the Molecular and Cellular Neurobiology series.This book reviews the recent advances in our understanding of the molecular and cellular mechanisms that control the assembly, transport, targeting and anchoring of the protein complexes making up the most important ion channels and receptor families, fundamental to synaptic function. Improvedunderstanding of these processes is expected to reveal novel therapeutic targets relevant to a range of disease states.The first section of the book contains three chapters dealing with cation channels and provides an accessible, succinct and comprehensive account of what is known about the structures and the assembly and targeting of these multimeric proteins. The focus of the book then moves on to coverligand-gated ion channels with two chapters on acetylcholine receptors. The final section of the book contains four chapters covering the excitatory and inhibitory amino acid receptors. Receptor and Ion-Channel Trafficking provides an integrated overview of the significant recent advances in the field of molecular neurobiology and will be essential reading for all researchers in neuroscience, neurobiology, biochemistry, cellular and molecular biology.

Author Biography

Stephen J. Moss: Professor of Molecular Pharmacology and Cell Biology, University College London Jeremy Henley: Professor of Molecular Neuroscience, University of Bristol

Table of Contents

List of Contributors	xi
Plate Section 180--181
Part 1 ION CHANNELS
Voltage-gated sodium channels	3	(25)
Misbah Malik-Hall
John N. Wood
Kenji Okuse
The assembly and targeting of potassium channels	28	(30)
Andrew Tinker
Assembly and targeting of voltage-dependent calcium channels	58	(31)
Annette C. Dolphin
Part 2 ACETYLCHOLINE RECEPTORS
Targeting of acetylcholine receptors to the postsynaptic endplate of the nerve-muscle synape	89	(20)
Sheridan L. Swope
Assembly and targeting of neuronal nicotinic acetylcholine receptors	109	(22)
Neil S. Millar
Part 3 AMINO ACID RECEPTORS
AMPA/kainate receptors	131	(25)
Nicole L. Stricker
Richard L. Huganir
NMDA receptor targeting	156	(15)
Heike Hering
Morgan Sheng
Structure, assembly and targeting of glycine receptors	171	(21)
Kirsten Harvey
Jeska von der Nuell
Robert J. Harvey
GABAA and GABAC receptors: regulation of assembly, localization, clustering and turnover	192	(27)
Bernhard Luscher
Index	219