Regenerating the Heart

by Cohen, Ira S.; Gaudette, Glenn R.

• ISBN13: 9781617790201
• ISBN10: 1617790206
• Format: Hardcover
• Copyright: 2011-04-06
• Publisher: Humana Pr Inc

Summary

Medical research made huge strides in treating heart disease in the 20thcentury, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a new millennium, scientists are gearing up for the next great challenges in tackling this pervasive condition. Cell therapy is going to be a key weapon in the fight against heart disease. It has the potential to address many cardiovascular conditions. From heart failure to atrioventricular nodal dysfunction, the young but promising field of cell therapy is set to play a significant role in developing the cures that the upcoming decades of hard work will yield.Regeneratingthe Heart: Stem Cells and the Cardiovascular System organizes the fieldinto a digestible body of knowledge. Its four sections cover mechanicalregeneration, electrical regeneration, cardiac tissues and in vivo stem celltherapies. An array of talented researchers share the fruits of their labors,with chapters covering such crucial issues as the cardiogenic potential ofvarying stem cell types, the ways in which they might be used to tacklearrhythmias, their possible application to biological replacements for cardiactissues such as valves, and the varying approaches used in the in vivoevaluation of stem cell therapies, including methods of delivering stem cellsto the myocardium.Thiscomprehensive survey of an area of research with such exciting potential is aninvaluable resource both for veteran stem cell researchers who need to monitorfresh developments, and for newly minted investigators seeking inspirationalexamples.

Table of Contents

Introduction	p. 1
Stem Cells for Regeneration of Mechanical Function
Inducing Embryonic Stem Cells to Become Cardiomyocytes	p. 7
Regenerating Function In Vivo with Myocytes Derived from Embryonic Stem Cells	p. 25
Excitation-Contraction Coupling, Functional Properties, and Autonomic and Hormonal Regulation in Human Embryonic Stem Cell Derived Cardiomyocytes	p. 37
Embryonic Stem Cell Derivatives for Cardiac Therapy: Advantages, Limitations, and Long-Term Prospects	p. 53
Methods for Differentiation of Bone-Marrow-Derived Stem Cells into Myocytes	p. 67
Homing, Survival, and Paracrine Effects of Human Mesenchymal Stem Cells	p. 83
Bone Marrow Cell Therapy After Myocardial Infarction: What have we Learned from the Clinical Trials and Where Are We Going?	p. 111
Evidence for the Existence of Resident Cardiac Stem Cells	p. 131
Multiple Sources for Cardiac Stem Cells and Their Cardiogenic Potential	p. 149
Skeletal Muscle Stem Cells in the Spotlight: The Satellite Cell	p. 173
Regenerating Mechanical Function In Vivo with Skeletal Myoblasts	p. 201
Methods for Inducing Pluripotency	p. 219
Inducible Pluripotent Stem Cells for Cardiac Regeneration	p. 241
Induced Pluripotent Cells for Myocardial Infarction Repair	p. 263
Stem Cells for Regeneration of Electrical Function
Substrates of Cardiac Reentrant Arrhythmias: The Possible Role of Tissue Regeneration and Replacement	p. 283
Integration of Stem Cells into the Cardiac Syncytium: Formation of Gap Junctions	p. 301
Bradyarrhythmia Therapies: The Creation of Biological Pacemakers and Restoring Atrioventricular Node Function	p. 321
Tachyarrhythmia Therapies: Approaches to Atrial Fibrillation and Postinfarction Ventricular Arrhythmias	p. 349
Long-Term Prospectus for Arrhythmia Treatment: Advantages and Limitations of Gene and Cell Therapies	p. 379
Regenerating Cardiac Tissues
Regenerating Blood Vessels	p. 393
Regenerating Heart Valves	p. 403
Tissue Engineering Strategies for Cardiac Regeneration	p. 443
Technical Issues for Stem Cell Therapy in the Heart
Methods of cell Delivery for Cardiac Repair	p. 479
Tracking of Stem Cells In Vivo	p. 449
Assessing Regional Mechanical Function After Stem Cell Delivery	p. 523
Index	p. 543
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