Regulation of Gene Expression

by Gary H. Perdew; Jack P. Vanden Heuvel; Jeffrey M. Peters

• ISBN13: 9781597452281
• ISBN10: 1597452289
• Format: Nonspecific Binding
• Copyright: 2008-08-17
• Publisher: Springer Nature

Table of Contents

Preface	p. v
Companion CD	p. ix
Gene Expression Control at the mRNA Level	p. 1
Overview	p. 3
Messenger RNA Accumulation	p. 11
Transcript Profiling	p. 31
Transcriptional Regulation of Gene Expression	p. 49
Posttranscriptional Processing of Messenger RNA	p. 105
Study Questions	p. 141
References	p. 143
Regulation of Protein Levels and Transcription Factor Function	p. 147
Contents	p. 147
Overview	p. 149
Protein Synthesis and Turnover	p. 155
Proteomics	p. 161
Determination of Protein-Protein Interactions and the Motifs That Mediate Them	p. 173
Posttranslational Modifications	p. 215
Dissection of Signaling Pathways	p. 239
Study Questions	p. 259
References	p. 261
Use of Transgenic and Knockout Mice to Study Gene Regulation	p. 265
Contents	p. 265
Overview	p. 267
Production of Transgenic Animals	p. 271
Knockout Animals	p. 295
Isolation of Cells and Cell Lines From Transgenic and Knockout Animals	p. 319
Study Questions	p. 321
References	p. 323
Index	p. 329
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