Schaechter's Mechanisms of Microbial Disease

by Engleberg, N. Cary; DiRita, Victor; Dermody, Terry

• ISBN13: 9780781753425
• ISBN10: 0781753422
• Edition: 4th
• Format: Paperback
• Copyright: 2006-04-06
• Publisher: LWW

Summary

Now in full color, the Fourth Edition of this text gives students a thorough understanding of microbial agents and the pathophysiology of microbial diseases. The text facilitates learning and recall by emphasizing unifying principles and paradigms, rather than forcing students to memorize isolated facts by rote. Case studies with problem-solving questions give students insight into clinical applications of microbiology. Each chapter ends with review and USMLE-style questions. For this edition, all schematic illustrations have been re-rendered in full color and new illustrations have been added. A new online site for students includes animations, USMLE-style questions, and all schematic illustrations and photographs from the text.

Table of Contents

Preface	v
Acknowledgments	vii
Contributors	ix
Figure Credits	xv
Part I: Principles	1	(138)
Establishment of Infectious Diseases	3	(8)
Normal Microbial Flora	11	(7)
Biology of Infectious Agents	18	(21)
Genetic Approaches to Studying Bacterial Pathogenesis	39	(17)
Biological Basis for Antibacterial Action	56	(10)
Innate Immunity	66	(24)
Adaptive Immunity	90	(26)
The Parasite's Way of Life	116	(10)
Damage by Microbial Toxins	126	(13)
Part II: Infectious Agents	139	(414)
SECTION 1 BACTERIA
Introduction to the Pathogenic Bacteria	141	(6)
Staphylococci: Abscesses and Toxin-Mediated Diseases	147	(9)
Streptococci and Enterococci: Sore Throats and Beyond	156	(8)
Pneumococcus and Bacterial Pneumonia	164	(9)
Neisseriae: Gonococcus and Meningococcus	173	(10)
Bacteroides and Abscesses	183	(7)
Enteric Bacteria: Secretory Diarrhea	190	(10)
Invasive and Tissue-Damaging Enteric Bacterial Pathogens: Bloody Diarrhea and Dysentery	200	(15)
Pseudomonas aeruginosa: A Ubiquitous Pathogen	215	(8)
Bordetella pertussis and Whooping Cough	223	(7)
Clostridia: Diarrheal Disease, Tissue Infection, Botulism, and Tetanus	230	(6)
Legionella: Parasite of Amebas and Macrophages	236	(7)
Helicobacter pylori: Pathogenesis of a ``Slow'' Bacterial Infection	243	(8)
Mycobacteria: Tuberculosis and Leprosy	251	(12)
Treponema pallidum and Syphilis: A Disease With a History	263	(8)
Borrelia burgdorferi and Lyme Disease	271	(9)
Cat Scratch Disease, Bacillary Angiomatosis, and Other Bartonelloses	280	(4)
Chlamydiae: Genital, Ocular, and Respiratory Pathogens	284	(8)
Rocky Mountain Spotted Fever and Other Rickettsioses	292	(8)
Mycoplasma: Curiosity and Pathogen	300	(5)
Strategies to Combat Bacterial Infections	305	(7)
SECTION 2 VIRUSES
Biology of Viruses	312	(18)
Picornaviruses and Coronaviruses	330	(10)
Arthropodborne Viruses	340	(7)
Paramyxoviruses: Measles Virus and Respiratory Syncytial Virus	347	(10)
Rabies	357	(6)
Influenza and Its Viruses	363	(7)
Rotaviruses, Noroviruses, and Other Viral Agents of Gastroenteritis	370	(6)
Human Retroviruses: AIDS and Other Diseases	376	(13)
Adenoviruses	389	(10)
Human Papillomaviruses and Warts	399	(7)
Alphaherpesviruses: Herpes Simplex Virus and Varicella-Zoster Virus	406	(9)
Betaherpesviruses and Gammaherpesviruses: Cytomegalovirus and Epstein-Barr Virus	415	(9)
Viral Hepatitis	424	(11)
Antiviral Treatment Strategies	435	(10)
Vaccines and Antisera for the Prevention and Treatment of Infectious Diseases	445	(6)
SECTION 3 FUNGI
Introduction to the Fungi and Mycoses	451	(4)
Endemic Mycoses	455	(8)
Opportunistic Fungal Infection	463	(9)
Subcutaneous, Cutaneous, and Superficial Mycoses	472	(5)
Antifungal Agents	477	(3)
SECTION 4 PARASITES
Introduction to Parasitology	480	(9)
Blood and Tissue Protozoa	489	(15)
Intestinal and Vaginal Protozoa	504	(9)
Intestinal Helminths	513	(10)
Tissue and Blood Helminths	523	(11)
SECTION 5 MISCELLANEOUS PATHOGENS
Prion Diseases	534	(7)
Biological Agents of Warfare and Terrorism	541	(12)
Part III: Pathophysiology of Infectious Diseases	553	(174)
Diagnostic Principles	555	(11)
Principles of Epidemiology	566	(6)
Digestive System Infections	572	(16)
Infections of the Central Nervous System	588	(15)
Respiratory System Infections	603	(12)
Urinary Tract Infections	615	(9)
Infections of the Skin and Soft Tissue	624	(10)
Infections of the Bones, Joints, and Muscles	634	(9)
Sepsis	643	(7)
Intravascular Infection	650	(9)
Head and Neck Infections	659	(7)
Sexually Transmitted Diseases	666	(7)
Infections of the Immunocompromised Patient	673	(6)
Acquired Immunodeficiency Syndrome	679	(12)
Congenital and Perinatal Infections	691	(6)
Zoonoses	697	(10)
Fever: A Clinical Sign of Infection	707	(6)
Health Care--Associated Infections	713	(6)
Foodborne Diseases	719	(8)
Index	727