Scientific Basis of Transfusion Medicine

by Anderson, Kenneth C., M.D.; Ness, Paul M.

• ISBN13: 9780721633022
• ISBN10: 0721633021
• Format: Hardcover
• Copyright: 1994-01-01
• Publisher: W B Saunders Co

Summary

The most comprehensive text of its kind, this resource offers a clear understanding of the principles underlying the use of blood products and transfusion techniques in clinical medicine. It includes discussions of hematopoiesis, red cells, granulocytes, platelets, intrauterine transfusion, transplantation, and transfusion-transmitted diseases. The 2nd Edition features new coverage of thrombopoietin, stem cell transplants, blood cell collection and detection as well as the impact of emerging technologies.

Table of Contents

Hematopoiesis	p. 1
Erythropoiesis	p. 1
Granulopoiesis	p. 13
Megakaryocytopoiesis and Platelet Kinetics	p. 30
Hematopoietic Growth Factors	p. 45
Immunology and Genetics	p. 59
T Lymphocytes and the Adaptive Immune Response	p. 59
The Humoral Immune Response	p. 84
Complement	p. 107
Transfusion Genetics	p. 120
Red Cells	p. 133
Red Cell Metabolism	p. 133
Red Cell Antigens	p. 145
Granulocytes	p. 163
Granulocyte Storage and Metabolism	p. 163
Granulocyte Immunology	p. 180
Platelets	p. 207
Platelet Storage and Metabolism	p. 207
Platelet Immunology	p. 227
Plasma Proteins	p. 237
Biochemistry of Plasma Proteins	p. 237
Hemostasis	p. 247
Fibrinolysis	p. 255
Plasma Protein Products	p. 291
Intrauterine and Neonatal Transfusion	p. 307
Intrauterine Transfusion	p. 307
Neonatal Transfusion	p. 321
Alloimmunization in Neonates	p. 337
Transplantation	p. 347
Transplantation Immunology	p. 347
Bone Marrow Stem Cells	p. 357
Peripheral Blood Stem Cells	p. 377
Cord Blood Stem and Progenitor Cells for Transplantation	p. 385
Immune Effects of Transfusion	p. 393
Alloimmunization to Blood Group Antigens	p. 393
Autoantibodies	p. 401
Platelet Alloimmunization	p. 409
Transfusion-Associated Graft-Versus-Host Disease	p. 420
Transfusion Immunomodulation	p. 427
Mechanisms Underlying the Immunomodulatory Effect of Allogeneic Blood Transfusion	p. 444
Transfusion-Transmitted Diseases	p. 455
Epidemiology of Transfusion-Transmitted Diseases	p. 455
Hepatitis	p. 472
Cytomegalovirus	p. 489
Human Immunodeficiency Viruses	p. 502
Emerging Technologies Applied To Transfusion	p. 514
Principles of Immunoassay	p. 514
Principles of Cell Survival, Kinetics, and Imaging	p. 532
Polymerase Chain Reaction and Transfusion-Related Infections	p. 542
Principles of Apheresis	p. 553
Alternatives to Allogeneic Blood Transfusion	p. 569
Red Cell Substitutes	p. 588
Viral Clearance Methods Applied to Blood Products	p. 599
Somatic Gene Therapy	p. 618
Index	p. 637
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