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| Contributing Authors | p. xi |
| Preface | p. xvii |
| Acknowledgments | p. xix |
| Introduction | |
| Organizational Principles | p. 3 |
| Embryonic Development of the Liver | p. 17 |
| The Cells | |
| Biology and Pathobiology of Actin in the Liver | |
| Cytoskeleton: Intermediate Filaments | |
| Gap and Tight Junctions in Liver: Composition, Regulation, and Function | p. 29 |
| Motor Molecules | p. 47 |
| Motor Molecules of the Cytoskeleton: Possible Functions in the Hepatocyte | |
| Gene Regulation and In Vivo Function of Liver Transcription Factors | p. 59 |
| The Hepatocyte Plasma Membrane: Organization, Differentiation, Biogenesis, and Turnover | p. 77 |
| Plasma Membrane: Biogenesis and Turnover | |
| Hepatocyte Basolateral Membrane Organic Anion Transporters | p. 83 |
| The Hepatocyte Surface: Dynamic Polarity | p. 97 |
| Hepatocyte Surface Polarity | |
| The Endoplasmic Reticulum and Golgi Complex in Secretory Membrane Transport | p. 119 |
| The Endoplasmic Reticulum-Golgi Membrane System | |
| Mechanisms of Nuclear Entry | |
| Molecular Mechanisms of Hepatocellular Vesicle Formation | p. 133 |
| Receptor-Mediated Endocytosis | p. 161 |
| Peroxisomal Assembly, Biology, and Disease Relationship | p. 179 |
| Peroxisomes | |
| Lysosomes | |
| Mitochondria | |
| Hepatocyte: Metabolism | |
| Energy Metabolism | |
| Integrated Cell Function: Apoptosis | p. 187 |
| Fundamentals of Cellular Osmoregulation | p. 207 |
| Roles of Intracellular Proteolysis in Hepatocyte Cell-Cycle, Aging, and Programmed Cell Death | p. 217 |
| Regulation of Hepatic Cholesterol Homeostasis | p. 231 |
| Lipoprotein Metabolism | |
| Leptin and the Liver | p. 249 |
| Hypoxic, Ischemic, and Reperfusion Injury to Liver | p. 257 |
| Protective Mechanisms Against Reactive Oxygen Species | p. 281 |
| Reactive Oxygen Species | |
| Detoxication: Oxidation and Reduction | |
| Detoxication: Conjugation and Hydrolysis | |
| Disorders of Bilirubin Metabolism | p. 291 |
| Heme and Bile Pigment Metabolism | |
| The Porphyrias | p. 311 |
| Heme Biosynthesis, the Porphyrias, and the Liver | |
| Copper Metabolism and the Liver | p. 331 |
| Copper and Zinc | |
| The Liver and Iron | p. 345 |
| Liver and Iron | |
| Retinoid (Vitamin A) Metabolism and the Liver | |
| Liver in Relation to Water-Soluble Vitamins | |
| Bile Secretion | |
| The Biology of the Bile Canaliculus | p. 361 |
| Bile Acids | |
| Enterohepatic Circulation | |
| Bile Flow | |
| Conjugate Export Pumps of the Multidrug Resistance Protein (MRP) Family in Liver | p. 373 |
| Genetic Defects of Canalicular Transport | p. 383 |
| Hormonal Regulation of Bile Secretion | p. 389 |
| Nucleotide Transport and Regulation of Bille Formation | p. 411 |
| The Pathobiology of Biliary Epithelia | p. 421 |
| The Biology of Biliary Epithelia | |
| Sinusoidal Cells | |
| Endothelial and Pit Cells | p. 437 |
| Hepatic Stellate Cells: Morphology, Function, and Regulation | p. 455 |
| Kupffer and Sinusoidal Endothelial Cells | |
| Extracellular Matrix | |
| The Extracellular Matrix of the Liver | p. 469 |
| Extracellular Matrix | |
| Integrins | p. 475 |
| Cell-Extracellular Matrix Interactions | |
| Interrelated Cell Functions | |
| Role of Inositol Trisphosphate and Diacylglycerol in the Regulation of Liver Function | p. 485 |
| Synthesis of and Signaling Through D-3 Phosphoinositides | p. 495 |
| Insulin and Other Growth Factors | p. 511 |
| Insulin, Insulin-Like Growth Factors and Their Receptors | |
| Cyclic AMP Signaling in the Liver: Coupling Transcription to Physiology and Proliferation | p. 525 |
| Ca[superscript 2+] Signaling in the Liver | p. 537 |
| Nitric Oxide in the Liver | p. 555 |
| Interleukin-6 Signaling During the Acute-Phase Response of the Liver | p. 565 |
| Leukotrienes and Other Eicosanoids in Liver Pathophysiology | |
| Innate Immune Sensing and the Toll-Like Receptors | p. 581 |
| Liver Regeneration | p. 591 |
| Liver Regeneration | |
| Hepatocyte Growth Factor: Its Role in Hepatic Growth and Pathobiology | p. 611 |
| The Organ | |
| Hepatic Microvascular System | |
| Flow, Cell Entry, Metabolic Disposal, and Product Formation in the Liver | |
| Relation to Other Organs | |
| Hepatic Encephalopathy | p. 633 |
| Alterations of the Kidney in Liver Disease | p. 649 |
| Kidney in Liver Disease | |
| Interaction of Liver, Muscle, and Adipose Tissue in the Regulation of Metabolism in Response to Nutritional and Other Factors | |
| Hypothalamic-Pituitary-Liver Axis: Growth Hormone Controls Liver Sex | |
| Vitamin K-Dependent Blood Coagulation Proteins | |
| Hemopoietic Functions of the Liver | |
| Hepatobiliary Influences on the Skeletal System | |
| Molecular Aspects of Aspects of Autoimmune Liver Disease | |
| Pathobiologic Analysis | |
| Molecular Pathophysiology of Membrane Transport Function in Cholestasis | p. 663 |
| The Biology of Portal Hypertension | p. 679 |
| [alpha]1-Antitrypsin Deficiency | p. 699 |
| Pathophysiology of Liver Fibrosis | p. 721 |
| Alcoholic and Nonalcoholic Steatohepatitis | p. 739 |
| Ethanol and the Liver | |
| Schistosomiasis: A Model of Immunologically Mediated Liver Disease | p. 755 |
| Immune Mechanisms of Viral Clearance and Disease Pathogenesis During Viral Hepatitis | p. 763 |
| Epidemiology, Natural History, and Prevention of Viral Hepatitis | p. 783 |
| Molecular Bases of Hepatitis B--and Hepatitis C--Related Chronic Liver Disease | p. 801 |
| Molecular Biology of Hepatitis Viruses | p. 831 |
| Liver Transplantation: Factors Affecting the Balance Between Tolerance and Rejection in Experimental Models | p. 857 |
| The Woodchuck Model of Hepatitis B Virus Infection | |
| Viral Hepatitis: Antiviral Therapy | p. 873 |
| Horizons | |
| Tissue Engineering of the Liver | p. 901 |
| A Genomic View of Hepatology: The Example of Liver Fibrosis | p. 909 |
| After Proteomics Comes Glycomics: How Proteins and Saccharides Interact and Influence Cell Biology | p. 917 |
| Liver Repopulation Through Cell Transplantation | p. 927 |
| Liver-Directed Gene Therapy | p. 941 |
| Novel Strategies for Manipulating Hepatic Gene Expression In Vivo | p. 963 |
| Regulation of the Eukaryotic Cell Cycle | p. 977 |
| Molecular and Cellular Control of Angiogenesis | p. 987 |
| Dynamics of Hepatitis B Virus Infection | p. 995 |
| Telomeres and Telomerase in Experimental Liver Cirrhosis | p. 1001 |
| Mechanism(s) of Hepatocarcinogenesis: Insight from Transgenic Mouse Models | p. 1013 |
| Orphan Nuclear Receptors and Regulation of Cholesterol and Bile Acid Metabolism | p. 1029 |
| Subject Index | p. 1041 |
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