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9780817636012

Nuclear Imaging in Drug Discovery, Development, and Approval

by ; ; ;
  • ISBN13:

    9780817636012

  • ISBN10:

    0817636013

  • Format: Hardcover
  • Copyright: 1993-01-01
  • Publisher: Birkhauser

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Summary

Advances in radiotracer technology in studies on experimental animals and in human beings, for application by pharmaceutical scientists. DNLM: Autoradiography.

Table of Contents

Foreword
Nuclear Imaging in Drug Development - Introductionp. 1
Nuclear Medicine Physics, Instrumentation, and Data Processing in Pharmaceutical Researchp. 11
Accelerators for Positron Emission Tomographyp. 33
Chemistry of Tracers for Positron Emission Tomographyp. 55
Single Photon, Gamma Emitting Radiotracers for Use in Imagingp. 75
The Design of Site-Directed Radiopharmaceuticals for Use in Drug Discoveryp. 113
Applications of Autoradiography to Drug Discoveryp. 135
Quantitative Whole Body Autoradiographic Microimaging for Pharmaceutical Researchp. 149
Cerebral Metabolic Rates of 2-[[superscript 18]F]Fluoro-2-Deoxy-D-Glucose in the Presence of Ofloxacin A GABA[subscript A] Receptor Antagonistp. 167
Positron Emission Tomography, Enzymes and Drug Research and Developmentp. 179
The Role of Positron Emission Tomography in Assessing and Monitoring Dopamine Active Drugsp. 201
Iodinated Dopamine D[subscript 1]1 and D[subscript 2] Receptor Imaging Agents for SPECTp. 227
Radiolabeled Atrial Natriuretic Peptide and Somatostatin for In Vivo Imaging of Receptorsp. 245
Use of Radionuclides in Experimental Vascular Thrombosisp. 265
Application of Nuclear Imaging to Drug Delivery Evaluation and Development: A Review of Radiolabeled, Injectable, Colloidal Systems of Deliveryp. 283
The Gastrointestinal Transit and Systemic Absorption of Diltiazem HCL from a Modified Release Dosage Formp. 301
The Potential Uses of Radiopharmaceuticals in the Pharmaceutical Industryp. 321
Indexp. 333
Table of Contents provided by Blackwell. All Rights Reserved.

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