Historic Overview | p. 1 |
Research Methodologies for Adult Neurogenesis | p. 5 |
Immunohistochemistry | p. 5 |
Markers of Proliferation | p. 5 |
Phenotypic Markers | p. 8 |
Electron Microscopy | p. 11 |
Neurosphere Assay | p. 17 |
Limitations of the Neurosphere Assay | p. 20 |
Fluorescence-Assisted Cell Sorting (FACS) Analysis in Stem Cell Research | p. 20 |
Transgenic Animals and the cre-lox System | p. 22 |
Transplantation of Adult NSCs | p. 23 |
Integration and Functionality of Newborn Cells in the Adult Brain | p. 25 |
Neurogenesis in the Intact Adult Mammalian Central Nervous System | p. 27 |
Description of Neurogenic Regions in the Adult Mammalian Brain | p. 27 |
Subventricular Zone | p. 27 |
Hippocampal Dentate Gyrus | p. 42 |
Concept of Neurogenic Niche | p. 45 |
Identification of the Adult Neural Stem Cell in the SVZ | p. 47 |
Other Proliferating and Neurogenic Centers in the Adult Brain | p. 49 |
The Subcallosal Region | p. 50 |
The Central Canal of the Spinal Cord | p. 50 |
Distinct Features of Different Species: Comparative Study of Mice and Humans | p. 53 |
Bovine Lateral Ventricles | p. 53 |
Rabbit Lateral Ventricles | p. 55 |
Primate Lateral Ventricles | p. 56 |
Human Lateral Ventricles | p. 58 |
Oncogenesis vs. Neurogenesis | p. 63 |
Adult Neurogenesis Under Pathological Stimulation: Ischemia | p. 67 |
Concept and Epidemiology | p. 67 |
Effects of Ischemia on the Brain and the SVZ | p. 69 |
Extracellular Factors and Neurogenesis After Stroke | p. 73 |
Stem Cell-Based Therapies in Ischemia | p. 74 |
Therapeutic Potential of Neural Stem Cells | p. 77 |
Concluding Remarks | p. 81 |
References | p. 85 |
Index | p. 103 |
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