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| In Memoriam | p. v |
| Foreword | p. vii |
| Preface | p. ix |
| Biography | p. xiii |
| Contributors | p. xix |
| Basic Concepts of TGF-[beta] Signaling in Normal Physiology and Cancer Pathobiology | |
| Component Hardware for Transforming Growth Factor-[beta] Signal Transduction: TGF-[beta] Ligands, TGF-[beta] Receptors, and Smads | p. 3 |
| TGF-[beta] Signaling in Homeostasis and Cancer | p. 23 |
| TGF-[beta] Availability: Latent TGF-[beta] and Latent TGF-[beta] Binding Proteins | p. 37 |
| Biological Functions of Latent TGF-[beta]-Binding Proteins and Activation of TGF-[beta] | p. 57 |
| Regulators of Smad2/3 Transcription and Phosphorylation | p. 77 |
| Interaction of Smad4 and Embryonic Liver Fodrin-[beta]-spectrin in Hyperplasia, Neoplasia, and Tumor Suppression | p. 91 |
| Regulation of Smad Activity by Phosphorylation | p. 105 |
| Nuclear Targeting of TGF-[beta]-Activated Smads in Normal and Tumor Biology | p. 125 |
| Ski, SnoN, and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival | p. 139 |
| Transforming Growth Factor-[beta] in Cancer Therapy: Smurfs in TGF-[beta] Signaling and Regulation of Bone Homeostasis and Cancer | p. 155 |
| Involvement of km23 Dynein Light Chains in TGF [beta] Signaling | p. 169 |
| TGF-[beta] Signaling in Fibroblastic Cells and Oncogenesis | p. 185 |
| Mechanisms of TGF-[beta]-Induced Apoptosis in Cancer Cells | p. 199 |
| Mechanisms of Cell Cycle Regulation by TGF-[beta] Disabled in Cancer | p. 213 |
| Transforming Growth Factor-[beta] in Cancer Therapy: Proteasome in the Control of TGF-[beta] Signaling During Development and Cancer | p. 243 |
| TGF-[beta] and Smad Signaling in Transcriptome Reprogramming During EMT | p. 259 |
| Functional Interactions Between MMPs and TGF-[beta] in Normal and Tumor Tissue | p. 275 |
| Cooperation Between TGF-[beta] and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function | p. 293 |
| Interaction of Oncogenic Ras and TGF[beta]1 Signaling in Cancer: Lessons From the Multistage Skin Carcinogenesis Model | p. 305 |
| TGF-[beta] Superfamily Members in Normal and Tumor Biology | |
| Proteomics Analysis of TGF[beta] Superfamily Members | p. 319 |
| Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally Occurring Therapeutic Agent for Certain Human Cancers | p. 333 |
| Activins, Inhibins, and Bone Morphogenetic Proteins as Modulators and Biomarkers of Prostate Cancer Progression | p. 355 |
| Bone Morphogenic Proteins and Angiogenesis in Developing Tumors | p. 373 |
| Histone Methyltransferase and Smad Interactions in BMP Signaling | p. 383 |
| Endoglin (CD105): A Strong Candidate for Immunologic Targeting of Tumor Neovasculature in Human Malignancies | p. 395 |
| Activins and Inhibins in Cancer Progression | p. 411 |
| Bone Morphogenetic Proteins/Growth Differentiation Factors and Smad Activation in Ovarian Granulosa Cells and Carcinoma | p. 425 |
| Regulation of the Transforming Growth Factor-[beta] Superfamily by Betaglycan | p. 451 |
| Uterine Sensitization Associated Gene-1: A Bone Morphogenetic Protein Antagonist with a Role in Kidney | p. 463 |
| Role of Betaig-h3 Gene in Carcinogenesis | p. 475 |
| Activins and the Liver | p. 483 |
| Myostatin Signaling in Normal and Tumor Cells | p. 509 |
| TGF-[beta] in Inflammation and Fibrosis | |
| Triterpenoids, Vitamin D, and TGF-[beta]/Smad Signaling in Inflammation and Cancer | p. 525 |
| Thrombospondin-Dependent Activation of Latent TGF-[beta] in Fibrosis and Disease | p. 549 |
| TGF-[beta] in Pulmonary Fibrosis | p. 569 |
| The Role of TGF-[beta] in Bleomycin Induced Pulmonary Fibrosis | p. 581 |
| Smads in the Fibrotic Response: Findings in the Smad3 Knockout Mouse | p. 595 |
| TGF-[beta] Signaling in Renal Fibrosis and Inflammation: Gene Therapy Using Ultrasound-Microbubble-Mediated Inducible Smad7 | p. 609 |
| Transforming Growth Factor-[beta] Peptide Signaling in Pulmonary Development, Bronchopulmonary Dysplasia, Fibrosis, and Emphysema | p. 621 |
| The Role of TGF-[beta] in Radiation and Chemotherapy Induced Pulmonary Fibrosis: Inhibition of TGF-[beta] as a Novel Therapeutic Strategy | p. 629 |
| Negative Regulation of the TGF-[beta] Family Signal Pathway by Inhibitory Smads and Their Involvement in Cancer and Fibrosis | p. 649 |
| TGF-[beta]-Related Antifibrotic Strategies in the Eye | p. 663 |
| Transforming Growth Factor-[beta] in Cutaneous Tissue Repair | p. 675 |
| Topical Application of TGF-[beta]1 Peptide Inhibitors for the Therapy of Skin Fibrosis | p. 693 |
| Overexpressed Truncated TGF-[beta] Type II Receptor Inhibits Fibrotic Behavior of Keloid Fibroblasts In Vitro and Experimental Scar Formation In Vivo | p. 703 |
| Index | p. 723 |
| Table of Contents provided by Ingram. All Rights Reserved. |
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