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9780792371373

Recombinant Protein Production With Prokaryotic and Eukaryotic Cells

by ; ; ; ; ; ;
  • ISBN13:

    9780792371373

  • ISBN10:

    0792371372

  • Format: Hardcover
  • Copyright: 2002-01-01
  • Publisher: Kluwer Academic Pub
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Summary

The general field of fundamental and applied biotechnology becomes increasingly important for the production of biologicals for human and veterinary use, by using prokaryotic and eukaryotic microorganisms. The papers in the present book are refereed articles compiled from oral and poster presentations from the EFB Meeting on Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology, which was organized in Semmering/A from 5th to 8th October 2000. A special feature of this meeting was the comparison of different classes of host cells, mainly bacteria, yeasts, filamentous fungi, and animal cells, which made obvious that many physiological features of recombinant protein formation, like cell nutrition, stress responses, protein folding and secretion, or genetic stability, follow similar patterns in different expression systems. This comparative aspect is by far the point of most interest because such comparisons are rarely done, and if they are done, their results are most often kept secret by the companies who generated them. Audience: Presently, a comparable book does not exist because the compiling of manuscripts from all fields of biotechnology (prokaryotic as well as eukaryotic, up to animal cell biotechnology) is not done in general. This particularity makes this book very interesting for postgraduate students and professionals in the large field of biotechnology who want to get a more global view on the current state of the expression of recombinant biologicals in different host cell systems, the physiological problems associated with the use of different expression systems, potential approaches to solve such difficulties by metabolic engineering or the use of other host cells, and the cooperation between process development and strain improvement, which is crucial for the optimisation of both the production strain and the process. This book should be in every library of an institution/organization involved in biotechnology.

Table of Contents

Foreword ix
Cell-free translation systems
Protein synthesis and co-translational folding in cell-free translation systems
1(16)
Spirin, A.S.
Metabolic burden and stress response
The cellular response to unfolded proteins in the endoplasmic reticulum
17(12)
Kaufman, R.
Scheuner, D.
Tirasophon, W.
Yin-Liu, C.
Song, B.
Lee, K.C.
McEwen, E.
Weir, S.-B.
The effects of recombinant protein expression on the growth and metabolism of mammalian cells
29(14)
Yallop, C.A.
Svendsen, I
Mapping stresses in Escherichia coli to improve yield. Examining global gene regulation and « cell conditioning » strategies
43(12)
DeLisa, M.P.
Gill, R.T.
Bentley, W.E
Cellular responses to strong overexpression of recombinant genes in Escherichia coli. DNA relaxation and cell death after induction of α-glucosidase
55(20)
Lin, H.Y.
Hanschke, R.
Nicklisch, S.
Nietsche, T.
Jarchow, R.
Schwahn, C.
Riemschneider, S.
Meyer, S.
Gupta, A.
Hecker, M.
Neubauer, P.
From Vitreoscilla hemoglobin (VHb) to a novel class of growth stimulating hemoglobin proteins
75(14)
Kallio, P.T.
Frey, A.D.
Bailey, J.E.
Genetic stability and gene copy number effects
Protein mass production in hybridomas and recombinant CHO cells
89(10)
Kunert, R.
Strutzenberger, K.
Steindl, F.
Zudjelovic, A.
Borth, N.
Katinger, H
Inducible gene copy number amplification for the production of heterologous proteins in Kluyveromyces lactis
99(12)
Bianchi, M.M.
Antibiotic-free plasmid selection and maintenance in Bacteria
111(14)
Hanak, J.A.J.
Cranenburgh, R.M.
Modelling of segregational plasmid instability of recombinant strain suspension of Escherichia coli
125(16)
Boudrant, J.
Le, B.-L.
Fournier, F.
Fonteix, C.
Transcription, translation, and product formation in E. coli
Production of optically pure aryl epoxides by recombinant E. coli carrying styrene monooxgenase. A new biocatalyst based on pseudomonas fluorescens ST genes
141(10)
Colmegna, A.
Sello, G.
Galli, E.
Bestetti, G.
Translational problems associated with the rare arginine CGG in Escherichia coli. Frameshifting at CGG codons
151(8)
McNulty, D.E.
Huddleston, M.J.
Claffee, B.
Green, S.
Sathe, G.
Reeves, R.
Patel, P.
Kane, J.F.
Optimisation of the solubility of the recombinant Itk kinase domain in Escherichia coli
159(12)
Meinander, N.
Jeppsson, M.
Sogaard, M.
Bacterial senescence and the oxidation paradox
171(8)
Nystrom, T.
Ballesteros, M.
Fredriksson, A
Metabolic approaches for the optimisation of recombinant fermentation processes
179(10)
Striedner, G.
Cserjan-Puschmann, M.
Grabherr, R.
Clementschitsch, F.
Nilsson, E.
Bayer, K.
Control and optimisation of cellular bottlenecks in recombinant protein production
189(6)
Sanden, A.M.
Larsson, G.
Expression and fermentation strategies for recombinant protein production in Escherichia coli.
195(64)
Neubauer, P.
Winter, J.
Transcription, translation, and product formation in microbial systems other than E. coli
Overexpression of a Rhizopus oryzae lipase in Pichia pastoris strains containing multiple copies of the target gene
259(10)
Serrano, A.
Cereghino, G.L.
Ferrer, P.
Cregg, J.M.
Valero, F.
Development of a heterologous gene expression system for use in Lactococcus lactis. A novel gram-positive expression system
269(8)
Bredmose, L.
Madsen, S.M.
Vrang, A.
Ravn, P.
Johnsen, M.G.
Glenting, J.
Arnau, J.
Israelsen, H.
Metabolic network analysis for human therapeutic protein productions: effects of the P/O ratio
277(12)
Calik, P.
Ozdamar, T.H.
Animal cell based expression systems - process optimisation
Process-orientated metabolic engineering: cell lines with new properties in nutrient exploitation and protein glycosylation
289(14)
Wagner, R.
Influence of the metabolic status of packaging cells on retroviral vector production
303(16)
Merten, O.-W.
Landric, L.
Danos, O.
Optimizing the production of recombinant prion protein from CHO cells
319(12)
Bocking, S.P.
Steane, S.E.
Saini, S.
Bennett, A.D.
Recombinant protein production by transient transfection of suspension-growing cells
331(8)
Durocher, Y.
Perret, S.
Kamen, A.
Comparison of different microbial expression systems
Production of recombinant human trypsinogen in Escherichia coli and Pichia pastoris. A comparison of expression systems
339(8)
Hohenblum, H.
Naschberger, S.
Weik, R.
Katinger, H.
Mattanovich D.
Secretion of homologous and heterologous recombinant proteins in Escherichia coli and other gram-negative bacteria by using a new secretion system
347(12)
Miksch, G.
Flaschel, E.
Monitoring of genes that respond to overproduction of insoluble recombinant proteins in Escherichia coli and Bacillus subtilis
359(12)
Schweder, T.
Jurgen, B.
Model supported optimization of fed-batch fermentations for recombinant protein production
371(12)
Volk, N.
Franco-Lara, E.
Galvanauskas, V.
Lubbert, A.
Protease secretion capacity and performance analysis of recombinant Bacillus species
383(10)
Calik, P.
Kalender, N.
Ozdamar, T.H.
Subject Index 393(6)
Authors Index 399

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