This volume provides a summary review of all recently published and ongoing research initiatives related to Tourette Syndrome. The latest research is presented in a clinical context, and controversial issues are fully discussed using an evidence-based approach. These issues include the prevalence of TS, the nature of the TS phenotype, the role of autoimmunity in the development of TS, the role of comorbidity in functional outcomes of TS patients, and approaches to identifying the TS gene/genes. Chapters describe recent advances in neuroimaging, genetics, and treatment. The book includes extensive discussions of co-morbid disorders: obsessive-compulsive disorder, attention deficit hyperactivity disorder, mood disorders, and tics.

Contributing Authors

xi

Preface

xv

Section 1: Clinical Phenomenology

Phenomenology and Natural History of Tic Disorders

1

(16)

James F. Leckman

Michael H. Bloch

Robert A. King

Lawrence Scahill

Section 2: Co-Morbid Disorders

Attention Deficit Hyperactivity Disorder: The Childhood Co-Morbidity That Most Influences the Disability Burden in Tourette Syndrome

17

(5)

Martha Bridge Denckla

Obsessive-Compulsive Disorder in Tourette Syndrome

22

(17)

Ana G. Hounie

Maria Conceicao do Rosario-Campos

Juliana Diniz

Roseli G. Shavitt

Ygor Ferrao

Antonio Carlos Lopes

Marcos Tomanik Mercadante

Geraldo Busatto

Euripedes C. Miguel

Behavioral and Affective Disorders in Tourette Syndrome

39

(22)

Mary M. Robertson

Tics Associated with Other Disorders

61

(8)

Joseph Jankovic

Nicte I. Mejia

Section 3: New Findings in Basic Neurosciences

Preclinical Models Relevant to Tourette Syndrome

69

(20)

Neal R. Swerdlow

Ashley N. Sutherland

Neurobiology of Basal Ganglia and Tourette Syndrome: Basal Ganglia Circuits and Thalamocortical Outputs

89

(10)

Jonathan W. Mink

Neurobiology of Basal Ganglia and Tourette Syndrome: Striatal and Dopamine Function

99

(8)

Roger L. Albin

Section 4: Neuroimaging and Neurophysiology

Motor Cortex Inhibitory Function in Tourette Syndrome Attention Deficit Disorder, and Obsessive Compulsive Disorder: Studies Using Transcranial Magnetic Stimulation

107

(8)

Donald L. Gilbert

Functional Neuroimaging of Tourette Syndrome: Advances and Future Directions

115

(15)

Tracy Butler

Emily Stern

David Silbersweig

Section 5: Genetics and Molecular Biology of TS

A Genome-Wide Scan and Fine Mapping in Tourette Syndrome Families

130

(6)

David L. Pauls

Web-Based Consensus Diagnosis for Genetics Studies of Gilles de la Tourette Syndrome

136

(8)

William M. McMahon

Cornelia L. Illmann

Meghan M. McGinn

Genes and Tourette Syndrome: Scientific, Ethical, and Social Implications

144

(4)

Nancy M. P. King

Section 6: Immunology and TS

Preclinical/Clinical Evidence of Central Nervous System Infectious Etiology in PANDAS

148

(11)

Tanya K. Murphy

David S. Husted

Paula J. Edge

PANDAS: Overview of the Hypothesis

159

(7)

Gavin Giovannoni

Autoimmunity and Pediatric Movement Disorders

166

(13)

Harvey S. Singer

Phillip N. Williams

PANDAS: To Treat or Not to Treat?

179

(5)

Robert A. King

Section 7: Epidemiology and Defining the Phenotype

Disruptive Behavior Problems in a Community Sample of Children with Tic Disorders

184

(7)

Lawrence Scahill

Susan Williams

Mary Schwab-Stone

Judy Applegate

James F. Leckman

Section 8: Advances in Treatment

Treatment of Tics

191

(6)

Leon S. Dure IV

Jennifer DeWolfe

Attention Deficit Hyperactivity Disorder, Chronic Tic Disorder, and Methylphenidate

197

(11)

Kenneth D. Gadow

Jeffrey Sverd

Treatment of Co-Morbid Obsessive Compulsive Disorder, Mood, and Anxiety Disorders

208

(14)

Barbara J. Coffey

Rachel Shechter

Treatment of Aggression in Tourette Syndrome

222

(5)

Cathy L. Budman

Behavioral Treatments for Tic Suppression: Habit Reversal Training

227

(7)

John Piacentini

Susanna Chang

Behavior Therapy: Other Interventions for Tic Disorders

234

(7)

Douglas W. Woods

Michael B. Himle

Christine Conelea

Behavioral Neurosurgery

241

(7)

Donald Malone

Mayur Pandya

Future and Alternative Therapies in Tourette s Syndrome

248

(7)

Roger Kurlan

Subject Index

255

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Tourette Syndrome

9780781799706

0781799708

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