Sleep Apnea: Pathogenesis, Diagnosis and Treatment

by Pack; Allan I.

• ISBN13: 9780849396977
• ISBN10: 0849396972
• Edition: 2nd
• Format: Hardcover
• Copyright: 2011-11-11
• Publisher: CRC Press

Summary

Since the publication of Sleep Apnea: Diagnosis and Treatmen - First Edition there have been many significant changes within the field of sleep disorders. This source will highlight the changes in the field of sleep apnea while examining new treatment techniques, new treatment data, and emerging data that relates to specific disorders.

Author Biography

Allan I. Pack, M.B.Ch.B., Ph.D., is the Director of the Center for Sleep and Cirrcadian Neurobiology and the Chief of the Division of Sleep Medicine at the University of Pennsylvania. He received his doctorate degrees from the University of Glasgow in Scotland and has been-practicing in the United States for over thirty years. Dr. Pack, Professor of Medicine, is the recipient of the John Miclot endowed chair. He is a member of multiple medical societies including the American Academy of Sleep Medicine, the World Federation of Sleep Research and Sleep, and the American Thoracic Society. The author of numerous scientific articles, Dr. Pack serves as a Deputy Editor for Sleep. Dr. Pack is a leading sleep medicine expert who has lectured all over the world. In addition, he has received the following awards: Nathaniel Kleitman Distinguished Service Award (1996, American Academy of Sleep Medicine), William C. Dement Academic Achievement Award (2001, American Academy of Sleep Medicine), and the Lifetime Achievement Award (2010, National Sleep Foundation).

Table of Contents

Foreword

Pathogenesis of Apnea

Anatomy/Biomechanics

Anatomical Factors-Insights from Imaging Studies

Biomechanics of the Upper Airway During Sleep

Secondary Changes in Upper Airway Structure and Function

Neural Mechanisms

Sleep-Induced Respiratory Instabilities

Mechanisms of Upper Airway Hypotonia Autonomic Consequences of Arousal from Sleep and Neural Mechanisms of Arousal

Genetics

The Genetics of the Obstructive Sleep Apnea-Hypopnea Syndrome

Studies in Humans

Airway Reflexes-Changes with Sleep

Gender Differences in Sleep-disordered Breathing

Animal Models

Animal Models of Sleep Apnea

Pathogenesis of Consequences of Apnea

Sleepiness

Mechanisms of Sleepiness in Obstructive Sleep Apnea

Neuroimaging Studies in Obstructive Sleep Apnea

Functional Genomics Approach to Sleepiness

Cardiovascular Consequences

Hypertension in Obstructive Sleep Apnea

Other Cardiovascular Consequences of Sleep Apnea

Endocrine

Neuroendocrine Changes in Sleep Apnea

Insulin Resistance in Sleep Apnea

Intermittent Hypoxia

Intermittent Hypoxia and Neurocognitive Function

Intermittent Hypoxia-Mechanisms and Other Neuronal Effects

Diagnosis of Sleep Apnea

Screening for Sleep Apnea

Simplified Diagnostic Tests for Obstructive Sleep Apnea

Sleep Apnea in Specialized Groups

Obstructive Sleep Apnea: Children Versus Adults

Sleep Apnea in Older Adults

Sleep Apnea in Pregnancy and Effect of Menopause

Treatment of Sleep Apnea

Adherence to CPAP Treatment and Functional Status in Adult Obstructive Sleep Apnea

CPAP Therapy: Results of Randomized Controlled Trials in Obstructive Sleep Apnea

Oral Appliance Therapy for Snoring and Sleep Apnea

Upper Airway Surgery for Obstructive Sleep Apnea

Pharmacotherapeutic Trials for Sleep-Disordered Breathing

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