Steroid Hormone Action

by Parker, Malcolm G.

• ISBN13: 9780199633920
• ISBN10: 0199633924
• Format: Paperback
• Copyright: 1993-11-25
• Publisher: IRL Press

Summary

Steroid Hormone Action is a comprehensive overview of the molecular mechanisms by which these hormones regulate the expression of specific target genes. The book covers the structure of steroid receptors, transcriptional activation and repression, and also contains chapters on steroid binding proteins and steroidogenesis. Steroid receptors represent one of the best characterized transcription factors so that the book will be of general interest to molecular biologists studying eukaryotic gene regulation. Chapters on the mechanisms of action of steroid antagonists and defective receptors in target cells will be of particular interest to endocrinologists and clinicians. In such a rapidly progressing field it is difficult to keep up with all the literature. Written by international experts, this book focuses on the most important advances that have been made recently.

Table of Contents

Extracellular steroid-binding proteins

Importance of steroidogenesis in specific hormone action

Overview of the steroid receptor superfamily of gene regulatory proteins

Role of heat-shock proteins in steroid receptor function

Nuclear hormone receptors as transcriptional activators

Repression of transcription by nuclear receptors

Structure and function of the steroid receptor zinc finger region

Mechanism of action of hormone antagonists

Mutations in steroid hormone receptors causing clinical disease

Index

Table of Contents provided by Publisher. All Rights Reserved.