Steroid Hormone Action

by Parker, Malcolm G.

• ISBN13: 9780199633937
• ISBN10: 0199633932
• Format: Hardcover
• Copyright: 1993-11-25
• Publisher: Oxford University Press

Summary

As well as being important physiologically, steroid-responsive systems have been widely used as models for studying eukaryotic gene structure, action, and regulation. This volume is a comprehensive description of the molecular mechanisms by which steroid hormones regulate the expression of specific target genes. Topics covered in detail include the structure of steroid receptors, transcriptional activation and repression, steroid binding proteins, and steroidogenesis.
Steroid Hormone Action is an up-to-date text, written by international experts, which brings together the most important recent advances in this field. It is a superb guide for molecular biologists, pharmacologists, and clinicians interested in gene regulation, hormones and steroid antagonists, and endocrine-related disorders.

Table of Contents

Extracellular steroid-binding proteins

Importance of steroidogenesis in specific hormone action

Overview of the steroid receptor superfamily of gene regulatory proteins

Role of heat-shock proteins in steroid receptor function

Nuclear hormone receptors as transcriptional activators

Repression of transcription by nuclear receptors

Structure and function of the steroid receptor zinc finger region

Mechanism of action of hormone antagonists

Mutations in steroid hormone receptors causing clinical disease

Index

Table of Contents provided by Publisher. All Rights Reserved.