Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis

by Beck-Peccoz, Paolo

• ISBN13: 9781402078071
• ISBN10: 1402078072
• Edition: 1st
• Format: Hardcover
• Copyright: 2004-05-01
• Publisher: SPRINGER

Summary

This volume covers the most recent scientific findings of the syndromes of hormone resistance in the HPT axis, i.e., thyroid hormone resistance and resistance to TSH action. Mechanisms of action of the various hormones, etiopathology of the syndromes, instruments for diagnosis, as well as the difficulties in managing these diseases are covered. In general, these disorders of HPT axis are uncommon and thus difficult to diagnose and treat. As a result, this book is a useful resource to clinicians and helps delineate the clinical flow-chart for both diagnosis and treatment.

Table of Contents

Preface	vii
Molecular basis of thyroid hormone action	1	(12)
Paul M. Yen
Tissues specific action of thyroid hormones: insights from knock out animal models	13	(22)
Michelina Plateroti
Cristina Angelin-Duclos
Frederic Flamant
Jacques Samarut
Learning from nature's experiments on the thyroid hormone receptor; X-ray structures of RTH mutant ligand-binding domains	35	(22)
Ben H. Sandler
John D. Baxter
Robert J. Fletterick
Molecular pathogenesis of resistance to thyroid hormone	57	(12)
V.K.K. Chatterjee
Syndromes of resistance to thyroid hormone: clinical aspects	69	(20)
Deborah Mannavola
Paolo Beck-Peccoz
Resistance to thyroid hormone in the absence of mutations in the thyroid hormone receptor genes	89	(20)
Samuel Refetoff
Peter M. Sadow
Sirimon Reutrakul
Kimberly Dennis
Deborah Mannavola
Joachim Pohlenz
Roy E. Weiss
Lessons learned from TR-β mutant mice	109	(10)
Fredric E. Wondisford
Towards the rational design of hormone analogs which complement receptor mutations	119	(18)
John T. Koh
Marc C. Putnam
Multi-factorial regulation of in vivo action of TRβ mutants. Lessons learned from RTH mice with a targeted mutation in the TRβ gene	137	(12)
Sheue-yann Cheng
The effect of vitamin A, retinoids and retinoid receptors on the hypothalamic-pituitary-thyroid axis	149	(16)
Bryan R. Haugen
Pituitary resistance to thyroxine action due to a defect in the type 2 deiodinase	165	(12)
Valerie Anne Galton
Different forms of resistance to thyrotropin (TSH) action	177	(16)
Luca Persani
Davide Calebiro
Tiziana de Filippis
Index	193