T Cells In Arthritis

by Miossec, Pierre; van den Berg, W.; Firestein, Gary S.

• ISBN13: 9783764358532
• ISBN10: 376435853X
• Format: Hardcover
• Copyright: 1998-08-01
• Publisher: Birkhauser

Summary

Rheumatoid arthritis (RA) is the most common and most severe form of inflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. The prevailing hypotheses have changed over the years, and have attempted to incorporate the most recent data. Although T cells represent an important component of the cells which infiltrate the joint synovium, their contribution at a late stage of the disease remains a matter of debate. The goal of this book is to outline the major arguments and data suggesting that T cells may, or may not, be central players in the pathogenesis of chronic RA. While each of the editors and authors has his/her own bias (as will be clear by reading the respective chapters), our hope is that the readers will enjoy a complete and balanced view of the critical questions and experiments. This is not just an intellectual exercise since the direction of future therapeutic interventions depends heavily on how one interprets the pathogenesis of RA and the contribution of T cells.

Table of Contents

List of contributors	vii
Preface	ix
T cell as secondary players in rheumatoid arthritis	1	(18)
Katherine H.Y. Nguyen
Gary S. Firestein
T cell receptor rearrangements in arthritis	19	(36)
David A. Fox
Nora G. Singer
T cell-independent joint destruction	55	(20)
Juliane K. Franz
Thomas Pap
Ulf Muller-Ladner
Renate E. Gay
Gerd R. Burmester
Steffen Gay
Role of T cell arthritis: Lessons from animal models	75	(18)
Wim B. van den Berg
The Th1/Th2 cytokine balance in arthritis	93	(18)
Pierre Miossec
Interactions between T cell plasma membranes and monocytes	111	(18)
Danielle Burger
Jean-Michel Dayer
Adhesion molecules in arthritis: Control of T cell migration into the synovium	129	(20)
Nancy Oppenheimer-Marks
Peter E. Lipsky
T cell reactivity to Epstein-Barr virus in rheumatoid arthritis	149	(20)
Marc Bonneville
Emmanuel Scotet
Marie-Alix peyrat
Annick Lim
Jacques David-Ameline
Elisabeth Houssaint
T cell responses in reactive and Lyme arthritis	169	(20)
Joachim Sieper
Jurgen Braun
T cell directed therapies and biologics	189	(12)
Ferdinand C. Breedveld
T cell as primary players in rheumatoid arthritis	201	(32)
Michael T. Falta
Brain L. Kotzin
Index	233