Targeted Cancer Therapy: A Handbook for Nurses

by Wilkes, Gail M.

• ISBN13: 9780763772116
• ISBN10: 0763772119
• Edition: 1st
• Format: Paperback
• Copyright: 2010-01-13
• Publisher: Jones & Bartlett Learning

Summary

Targeted Cancer Therapy: A Handbook for Nurses is an essential guide for nurses interested in the latest discoveries in oncology. Covering the most recent treatment option of transforming cancer into a chronic illness, Targeted Cancer Therapy provides nurses with the information they need to understand this and future developments in the field. This comprehensive but easy-to-understand text takes nurses through foundational concepts in cell and normal biology that are crucial to understanding cancer and targeted therapy. Featuring relevant analogies and easy-to-follow discussions on malignant transformation, metastases, cellular pathways, and toxicities, this one-of-a-kind text enables nurses to quickly get up to speed on key topics and develop care plans for oncology patients. Accessible, comprehensive, informative, Targeted Cancer Therapy is a must-read for every oncology nurse. Key features include: Easy-to-understand overview of biology Key topics in malignant transformation, invasion, and metastases Discussion on the microenvironment, angiogenesis, cellular pathways targeted during treatment, and potential drug side effects Care plan for patients receiving treatment Motivating patients dealing with cancer as a chronic illness

Table of Contents

Introduction	p. v
Cancer Biology, Signaling Pathways, and Malignant Transformation	p. 1
Hallmarks of Cancer	p. 1
Application of the Hallmarks of Cancer	p. 2
Invasion and Metastasis	p. 18
Epigenetics	p. 30
Summary	p. 34
References	p. 34
Targeted Cancer Therapy: External and Internal Signaling Pathway Targets	p. 39
Monoclonal Antibodies	p. 42
Membrane-Bound Receptor Kinases (e.g., EGFR, HER2, HGF/c-Met, IGFR pathways)	p. 73
Hepatocyte Growth Factor (HGF/c-Met) Receptor Pathway Targets	p. 125
Insulin-like Growth Factor Receptor Pathway Targets	p. 127
Intracellular Signaling Kinases (e.g., src, P13k/Akt/mTOR; MAPK; sonic hedgehog pathways)	p. 128
Protein Kinase Signaling Pathways	p. 129
Protein Kinase Inhibitors	p. 136
Protein Dynamics: Heat Shock Proteins and Ubiquitin-Proteasome Inhibitors	p. 150
Epigenetic Abnormalities (DNA Methyltransferase and Histone Deacetylase)	p. 160
Tumor Vasculature and Microenvironment	p. 175
References	p. 175
Tumor Vasculature	p. 185
Targeting Angiogenesis	p. 185
Antiangiogenic Drug Therapy	p. 194
Hypoxia-Inducible Factor, mTOR, and Angiogenesis	p. 198
Nursing Considerations and Drug Information	p. 203
References	p. 250
Targeting the Microenvironment: Bone Metastasis, Apoptosis, DNA Repair, and Mitosis	p. 255
Bone Metastasis	p. 255
Pharmacologic Management	p. 262
Targeting Apoptosis	p. 271
DNA Repair Gene Mutations: Opportunities from Synthetic Lethality	p. 277
Mitotic Kinase Inhibitors	p. 280
Summary	p. 284
References	p. 284
Challenges in Caring for Patients Receiving Targeted Therapy	p. 289
Drag Interactions: Focus on the P450 Microenzyme System	p. 289
Encouraging Patient Adherence and Persistence	p. 302
References	p. 310
Glossary	p. 313
Index	p. 329
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