Targeted Drug Delivery

by Bachhav, Yogeshwar; Mannhold, Raimund; Buschmann, Helmut; Holenz, Jö; rg

• ISBN13: 9783527347810
• ISBN10: 352734781X
• Edition: 1st
• Format: Hardcover
• Copyright: 2022-10-17
• Publisher: Wiley-VCH

Summary

Targeted Drug Delivery

Novel approaches in targeted drug delivery for both small molecule and biopharmaceutical drugs

Targeted Drug Delivery explores a new frontier in drug research that has become a focus for developing novel medications. The work discusses a wide range of approaches for targeting small molecules as well as peptide and macromolecular drugs, from prodrugs to drug conjugates to drug carriers and devices, helping readers to stay up to date on the latest developments in the field.

The following key topics are addressed:

• Antibody conjugates, prodrugs, and suicide gene therapeutics
• Protac technology for selectively degrading target proteins
• Delivery of nucleic acid drugs
• Novel drug carriers, such as liposomes, vesicles, and nanoparticles
• Unmet medical needs for which there is a large market potential, such as viral infections and cancer

For chemists, pharmacologists, and professionals in the wider pharmaceutical industry, Targeted Drug Delivery is a comprehensive guide on how to solve the greatest challenge in treating many diseases: delivering a pharmaceutically active substance to the target tissue in the body.

Author Biography

Yogeshwar Bachhav is a pharmacist by training and holds a PhD in drug delivery systems from ICT, Mumbai (India). He has worked as research scientist for several years on a collaborative project between Pantec Biosolutions and Geneva University (Switzerland), and as formulation manager at Debiopharm Group, Lausanne (Switzerland). In total, he has around 14 years of experience in the preformulation and formulation development of small molecules and/or peptides for oral, dermal and parenteral application.

Table of Contents

Basics of targeted drug delivery
Addressing unmet medical needs using targeted drug delivery systems
Nanocarriers-based targeted drug delivery systems for small molecules and macromolecules
Liposome based formulations for targeting small molecules and macromolecules
Antibody-Drug conjugates: development and applications
Suicide gene therapy for the treatment of cancer and viral infections
Targeted prodrugs in oral drug delivery
Use of exosomes for drug delivery
Delivery of nucleic acids such as siRNA and mRNA using complex drug delivery systems
Application of Protac technology in drug development
Inorganic metal carriers for targeted drug delivery
Formulation of peptides for targeted delivery