Textbook of Clinical Trials

by Machin, David; Day, Simon; Green, Sylvan

• ISBN13: 9780470010143
• ISBN10: 0470010142
• Edition: 2nd
• Format: Hardcover
• Copyright: 2007-01-08
• Publisher: WILEY

Summary

Now published in its Second Edition, the Textbook of Clinical Trials offers detailed coverage of trial methodology in diverse areas of medicine in a single comprehensive volume.Praise for the First Edition:"... very useful as an introduction to clinical research, or for those planning specific studies within therapeutic or disease areas." BRITISH JOURNAL OF SURGERY, Vol. 92, No. 2, February 2005The book's main concept is to describe the impact of clinical trials on the practice of medicine. It separates the information by therapeutic area because the impact of clinical trials, the problems encountered, and the numbers of trials in existence vary tremendously from specialty to specialty. The sections provide a background to the disease area and general clinical trial methodology before concentrating on particular problems experienced in that area. Specific examples are used throughout to address these issues.The Textbook of Clinical Trials, Second Edition: Highlights the various ways clinical trials have influenced the practice of medicine in many therapeutic areas Describes the challenges posed by those conducting clinical trials over a range of medical specialities and allied fields Additional therapeutic areas are included in this Second Edition to fill gaps in the First Edition as the number and complexity of trials increases in this rapidly developing area Newly covered or updated in the Second Edition: general surgery, plastic surgery, aesthetic surgery, palliative care, primary care, anaesthesia and pain, transfusion, wound healing, maternal and perinatal health, early termination, organ transplants, ophthalmology, epilepsy, infectious disease, neuro-oncology, adrenal, thyroid and urological cancers, as well as a chapter on the Cochrane network An invaluable resource for pharmaceutical companies, the Textbook of Clinical Trials, Second Edition appeals to those working in contract research organizations, medical departments and in the area of public health and health science alike.

Author Biography

David Machin, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.

Simon Day, Medicines and Healthcare Products Regulatory Agency, London, UK.

Sylvan Green, Arizona Cancer Center, Tucson, Arizona, USA.

Table of Contents

List of Contributors

Preface to Second Edition

Preface the First Edition

Introduction

The Development of Clinical Trials

General Statistical Issues

The Cochrane Collaboration

Cancer

Breast Cancer

Childhood Cancer

Gastrointestinal Cancers

Melanoma

Respiratory Cancers

Adrenal Cortical Carcinoma

Thyroid Cancer

Urologic Cancers

Haematologic Cancers: Challenges in Developing New Therapeutic Approaches

Cardiology

Acute Stroke

Cardiovascular Disease

Dentistry and Oral Health Care

Dentistry and Oral Health Care

Dermatology

Dermatology

Infectious Diseases

HIV Infection

Infectious Diseases

Ophthalmology

Ophthalmology

Psychiatry

Anxiety Disorders

Cognitive Behaviour Therapy

Psychotherapy for Depression

Reproductive Health

Contraception

Gynaecology and Infertility

Early Pregnancy Termination

Maternal and Perinatal Health

Respiratory

Respiratory Medicine

Surgery & Anaesthesia

Anaesthesia and Pain

General Surgery

Plastic Surgery - Reconstructive Surgery

Plastic Surgery - Aesthetic Surgery

Transplantation

Renal Transplantation

Other Procedures

Wound Healing

Palliative Care

Complementary Medicine

Cluster Randomized Trials in Health Care Research

Nursing

Special Populations

Clinical Trials in Paediatrics

Clinical Trials Involving Older People

Clinical Trials in Rare Diseases

Index

Table of Contents provided by Publisher. All Rights Reserved.