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Now in its fifth edition, the Textbook of Diabetes has established itself as the modern, well-illustrated, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the Textbook hosts an unrivalled blend of clinical and scientific content. Highly-experienced editors from across the globe assemble an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The fifth edition features an array of brand new chapters, on topics including:
as well as a new section on Psychosocial aspects of diabetes.
In addition, all existing chapters are fully revised with the very latest developments, including the most recent guidelines from the ADA, EASD, DUK and NICE.
Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Via the companion website, readers can access a host of additional online materials such as:
Once again, Textbook of Diabetes provides endocrinologists and diabetologists with a fresh, comprehensive and multi-media clinical resource to consult time and time again.
Richard I.G. Holt, MA, MB BChir, PhD, FRCP, FHEAProfessor in Diabetes & Endocrinology, Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton, UK.
Clive S. Cockram, MB BS, BSc, MD (Lond), FRCP, FRACP, FHKAM (Med)Emeritus Professor of Medicine, Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.
Allan Flyvbjerg, MD, DMScProfessor of Clinical Endocrinology and Chair, Department of Endocrinology and Internal Medicine, The Medical Research Laboratories, Aarhus University Hospital - Aarhus University, Aarhus, Denmark.
Barry J. Goldstein, MD, PhD, FACP, FACETherapeutic Area Head, Diabetes and Obesity, Vice President, Clinical Research, Metabolism, Merck Research Laboratories, Rahway, NJ, USA.
List of Contributors, viii
Preface to the Fifth Edition, xiv
List of Abbreviations, xv
About the Companion Website and Companion Digital Edition, xviii
Part 1 Diabetes in its Historical and Social Context
1 The History of Diabetes Mellitus, 3Robert B. Tattersall
2 Classification and Diagnosis of Diabetes, 23Ambady Ramachandran, Chamukuttan Snehalatha, and Arun Nanditha
3 Epidemiology of Type 1 Diabetes, 29Lars C. Stene and Jaakko Tuomilehto
4 Epidemiology of Type 2 Diabetes, 43Ronald C.W. Ma and Peter C.Y. Tong
5 The Global Burden of Diabetes, 65Mohammed K. Ali, Karla I. Galaviz, Mary Beth Weber, and K.M. Venkat Narayan
Part 2 Normal Physiology
6 Islet Function and Insulin Secretion, 87Peter M. Jones and Shanta J. Persaud
7 Glucagon in Islet and Metabolic Regulation, 103Darleen Sandoval, Jenny Tong, and David D’ Alessio
8 Mechanism of Insulin Action, 114Morris F. White
9 Control of Weight: How DoWe Get Fat?, 133Arianne N. Sweeting and Ian D. Caterson
Part 3 Pathogenesis of Diabetes
10 Autoimmune Type 1 Diabetes, 143Shehab Alshiekh, Helena Elding Larsson, Sten-A. Ivarsson, and ¢ª Ake Lernmark
11 Other Disorders with Type 1 Phenotype, 154Alice P.S. Kong, Elaine Y.K. Chow, and Juliana C.N. Chan
12 Abnormalities of Insulin Secretion and β-Cell Defects in Type 2 Diabetes, 161Stefano Del Prato, Cristina Bianchi, and Giuseppe Daniele
13 Insulin Resistance in Type 2 Diabetes, 174Michael Roden, Kitt Petersen, and Gerald Shulman
14 Genetic Architecture of Type 2 Diabetes, 187Rashmi B. Prasad and Leif Groop
15 Metabolic Disturbances in Diabetes, 205Adrian Vella and Robert A. Rizza
16 Obesity and Diabetes, 215Hans Hauner
17 The Microbiome and Diabetes, 229Amanda J. Cox, Nicholas P.West, and AllanW. Cripps
Part 4 Other Types of Diabetes
18 Monogenic Causes of Diabetes, 243Shivani Misra and Andrew T. Hattersley
19 Drug-Induced Diabetes, 262Charles D. Ponte and Devra K. Dang
20 Endocrine Disorders that Cause Diabetes, 272Rachel E. Jennings and Neil A. Hanley
21 Pancreatic Diseases and Diabetes, 291Ranjit Unnikrishnan and Viswanathan Mohan
Part 5 Managing the Patient with Diabetes
22 Clinical Presentations of Diabetes, 305Ee Lin Lim and Roy Taylor
23 The Aims of Diabetes Care, 314Katharine D. Barnard and Richard I.G. Holt
24 Educating the Person with Diabetes, 326Ingrid Willaing and Michael Vallis
25 Lifestyle Issues: Diet, 341Nicola Guess
26 Lifestyle Issues: Exercise, 353Mimi Z. Chen and Robert C. Andrews
27 Monitoring Diabetes, 374Andrew Farmer
28 Drug Therapy: Special Considerations in Diabetes, 385Bernard M.Y. Cheung and Ronald C.W. Ma
Part 6 Treatment of Diabetes
29 Insulin and Insulin Treatment, 401Stephen Gough and Parth Narendran
30 New Technologies for Glucose Monitoring and Insulin Administration, 414David L. Horwitz and David C. Klonoff
31 Oral Glucose-Lowering Agents, 426Clifford J. Bailey and Andrew J. Krentz
32 Non-Insulin Parenteral Therapies, 455Tina Vilsbøll, Mikkel Christensen, Tina Jorsal, and Filip K. Knop
33 How to Use Type 2 Diabetes Treatments in Clinical Practice: Combination Therapies, 471Silvio E. Inzucchi and David R. Matthews
34 In-Hospital Treatment and Surgery in People with Diabetes, 493Ketan Dhatariya and June James
35 Hypoglycemia in Diabetes, 513Philip E. Cryer and Ana María Arbeláez
36 Acute Metabolic Complications of Diabetes: Diabetic Ketoacidosis and the Hyperosmolar Hyperglycemic State, 534Niels Møller
Part 7 Microvascular Complications in Diabetes
37 Pathogenesis of Microvascular Complications, 543Allan Flyvbjerg
38 Diabetic Retinopathy, 554Toke Bek
39 Diabetic Nephropathy, 566Sally M. Marshall and Allan Flyvbjerg
40 Diabetic Peripheral and Autonomic Neuropathy, 580Dan Ziegler
Part 8 Macrovascular Complications in Diabetes
41 Pathogenesis of Macrovascular Complications in Diabetes, 611Stephen P. Gray, Elyse Di Marco, Riccardo Candido, Mark E. Cooper, and Karin A.M. Jandeleit-Dahm
42 Cardiovascular Risk Factors: Hypertension, 629Peter M. Nilsson
43 Diabetic Dyslipidemia and Risk of Cardiovascular Disease, 643Adie Viljoen, Supriya Joshi, and Anthony S.Wierzbicki
44 Ischemic Heart Disease in Diabetes, 653Christoph H. Saely, Kourosh Vathie, and Heinz Drexel
45 Congestive Heart Failure, 659Anna Norhammar, Isabelle Johansson, Inga S. Thrainsdottir, and Lars Rydén
46 Cerebrovascular Disease, 673Colum F. Amory and Jesse Weinberger
47 Peripheral Vascular Disease, 683Henrik H. Sillesen
Part 9 Other Complications of Diabetes
48 Foot Problems in People with Diabetes, 701Andrew J.M. Boulton
49 Sexual Function in Men andWomen with Diabetes, 716David Price
50 Gastrointestinal Manifestations of Diabetes, 731Adil E. Bharucha and Michael Camilleri
51 Diabetes and Non-Alcoholic Fatty Liver Disease, 745Shivakumar Chitturi and Geoffrey C. Farrell
52 The Skin in Diabetes, 759Graham R. Sharpe and Paul D. Yesudian
53 Bone and Rheumatic Disorders in Diabetes, 773Andrew Grey and Nicola Dalbeth
54 Diabetes and Cancer: Evidence for Risk, Methodology and Implications, 789Ellena Badrick and Andrew G. Renehan
55 Diabetes and Infections, 799Clive S. Cockram and Bonnie C.K.Wong
Part 10 Psychosocial Aspects of Diabetes
56 Psychological Factors and Diabetes Mellitus, 821Frans Pouwer and Jane Speight
57 Psychiatric Disorders and Diabetes, 840Richard I.G. Holt and Leslie Citrome
58 Social Aspects of Diabetes, 859Brian M. Frier and Mark W.J. Strachan
Part 11 Diabetes in Special Groups
59 Diabetes in Childhood, 879Shideh Majidi, Christine M. Chan, and Marian Rewers
60 Adolescence and Emerging Adulthood: Diabetes in Transition, 896Rebecca K. Snelgrove, Dayna E. McGill, and Lori M.B. Laffel
61 Diabetes in Pregnancy, 909Tim Cundy
62 Diabetes in Old Age, 939Ahmed H. Abdelhafiz and Alan J. Sinclair
63 Diabetes at the End of Life, 953June James, Jean MacLeod, and Robert Gregory
Part 12 Delivery and Organization of Diabetes Care
64 The Role of the Multidisciplinary Team Across Primary and Secondary Care, 963Samuel I. Seidu, Kamlesh Khunti, and Melanie J. Davies
65 Models of Diabetes Care Across Different Resource Settings, 973Naomi S. Levitt, Sam Surka, Andrew Farmer, and Bob Mash
Part 13 Future Directions
66 Future Drug Treatments for Type 1 Diabetes, 987Jennifer L. Sherr, Eda Cengiz, Michelle A. Van Name, Stuart A.Weinzimer, and William V. Tamborlane
67 Future Drug Treatments for Type 2 Diabetes, 1000Clifford J. Bailey
68 Stem Cell Therapy in Diabetes, 1012Angelo Avogaro and Gian Paolo Fadini
69 Islet Transplantation, 1017Angela Koh, Peter E. Senior, and A.M. James Shapiro
70 Gene Therapy for Diabetes, 1029Virginia Haurigot, Veronica Jimenez, and Fatima Bosch
71 Future Models of Diabetes Care, 1038Sanjeev N. Mehta and Robert A. Gabbay
Index, 1049
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