Textbook of Hemophilia

by Editor: Christine A. Lee (Professor of Haemophilia, Director and Consultant haematologist, Haemophilia Centre and Haemostasis Unit, The Royal Free Hospital, London, UK); Editor: Erik E. Berntorp (Professor of Haemophilia, Lund University; Director,

• ISBN13: 9781405143868
• ISBN10: 140514386X
• Format: eBook
• Copyright: 2008-06-01
• Publisher: Wiley-Blackwell

Summary

The only up-to-date definitive reference source on hemophiliaThis book is an invaluable resource that provides an overview of all aspects of the care of patients with haemophilia.Covering how to assess both bleeding children and adults, Haemophilia A and B, molecular basis of the disease, the role of factors in coagulation, epidemiology, pharmacokinetics, and treatment of inhibitors. There will also be a section on musculoskeletal aspects of haemophilia as well as newer developments such as gene therapy and rare bleeding disorders.Textbook of Hemophilia is ideal for: Trainees and residents in hematology Hematologists in practice Specialists working in thrombosis and hemostasis as well as transfusion medicineWhy Buy This Book?The only up-to-date definitive reference source on hemophilia Essential for all those managing hemophilia patients Detailed guidance on assessment, diagnosis, management and treatment Advice for everyday clinical questions Edited by three of the world's leading experts on hemophilia

Table of Contents

Contributors

Foreword

Introduction

Overview of Hemostasis

Cellular Processing of Factor VIII and IX

Work-up of a Bleeding Adult

Hemophilia A

Molecular Basis of Hemophilia A

Hemophilia A: Role of Factor VIII in Coagulation

Natural History of Inhibitor Development in Children with Severe Hemophilia A Treated with Factor VIII Products

Prophylaxis

Continuous Infusion of Coagulation Products in Hemophilia

Inhibitors to Factor VIII

Inhibitors to Factor VIII - Immunology

Inhibitors to Factor VIII - Molecular Basis

Inhibitors to Factor VIII - Epidemiology and Treatment

Inhibitors to Factor VIII - Mid and Moderate Hemophilia

Inhibitors to Factor VIII/IX: Treatment of Inhibitors - Immune Tolerance Induction

Inhibitors of Factor VIII: Treatment of Acute Bleeds

Acquired Hemophilia

Acquired Inhibitors to Factor VIII

Hemophilia B

Hemophilia B - Molecular Basis

Inhibitors in Hemophilia B

Treatment Inhibitors in Hemophilia B

Pharmacokinetics of Factors VIII & IX

Pharmacokinetics

Pediatrics

Work-up of a Bleeding Child

Care of the Child with Hemophilia

To Neonate with Hemophilia

Products Used to Treat Hemophilia

Products Used to Treat Hemophilia: Evolution of Treatment for Hemophilia A and B

Products Used to Treat Hemophilia: Recombinant Products

Products Used to Treat Hemophilia: Plasma-Derived Coagulation Factor Concentrates

Products Used to Treat Hemophilia: Recombinant Factor VIIa

Products Used to Treat Hemophilia: Dosing

Products Used to Treat Hemophilia: Regulation

Muscoskeletal

Joint Replacement

Synovioarthesis in Hemophilia

Pseudotumours in patients with Hemophilia

Radiology

Magnetic Resonance Imaging/ Joint Outcome

Physiotherapy in the Management of Hemophilia

Transfusion-Transmitted Disease

Transfusion Transmitted Disease: History of Epidemics

Transfusion Transmitted Disease: Hepatitis C Virus Infection and Liver Transplantation

Gene Therapy

Gene Therapy: Introduction and Overview

Gene Therapy for Hemophilia B

Gene Therapy for Hemophilia A

Gene Therapy: Molecular Engineering of Factor VIII and Factor IX

Laboratory

Laboratory Assays in Hemophilia

Standardization of Assays

Obstetrics & Gynaecology

Obstetrics and Gynecology: Hemophilia

Von Willebrand Disease

von Willebrand Disease: Molecular Aspects

von Willebrand Disease: Epidemiology

von Willebrand Disease: Biological Diagnosis

47Classification and Clinical Aspects of von Willebrand Disease

Treatment of Von Willebrand Disease

Treatment of von Willebrand Disease: Desmopressin

Treatment of von Willebrand Disease: Therapeutic Concentrates

Women & Von Willebrand Disease

Rare Bleeding Disorders

Factor II

Factor V and combined Factor V and VIII Deficiencies

Congenital Factor VII Deficiency

Factor X and Factor X Deficiency

Factor XI Deficiency

Factor XIII

Fibrinogen

Miscellaneous Rare Bleeding Disorders

Quality of Life

Quality of Life in Hemophilia

Economics

The Economics of Hemophilia Treatments

Comprehensive Care and Delivery of Care

Comprehensive Care and Delivery of Care: The Developed World

The Comprehensive Care and Delivery of Care: The Developing World

Comprehensive Care and Delivery of Care: The Global Perspective

Index

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