Textbook of Neural Repair and Rehabilitation

by Edited by Michael Selzer , Stephanie Clarke , Leonardo Cohen , Pamela Duncan , Fred Gage

• ISBN13: 9780521856416
• ISBN10: 0521856418
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-04-03
• Publisher: Cambridge University Press

Summary

In two freestanding volumes, Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. This volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal CNS, mechanisms of neuronal death, axonal regeneration, stem cell biology, and neuron replacement. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.

Table of Contents

Preface

Neural repair and rehabilitation: an introduction

Part A. Neural plasticity: Part A1. Cellular and molecular mechanisms of neural plasticity: 1 Anatomical and biochemical plasticity of neurons: regenerative growth of axons, sprouting, pruning, and denervation

supersensitivity

2 Learning and memory: basic principles and model systems

3 Short-term plasticity: facilitation and post-tetanic potentiation

4 Long-term potentiation and long-term depression

5 Cellular and molecular mechanisms of associative and nonassociative learning

Part A2. Functional plasticity in CNS system

6 Plasticity of mature and developing somatosensory systems

7 Activity-dependent plasticity in the intact spinal cord

8 Plasticity of cerebral motor functions: implications for repair and rehabilitation

9 Plasticity in visual connections: retinal ganglion cell axonal development and regeneration

10 Plasticity in auditory functions

11 Cross-modal plasticity in sensory systems

12 Attentional modulation of cortical plasticity

Section A3. Plasticity after injury to the CNS

13 Plasticity in the injured spinal cord

14 Plasticity after brain lesions

15 From bench to bedside: influence of theories of plasticity on human neurorehabilitation

Part B. Neural Repair: Part B1. Basic cellular and molecular processes

16 Neuronal death and rescue: neurotrophic factors and anti-apoptotic mechanisms

17 Axon degeneration and rescue

18 Adult neurogenesis and neural precursors, progenitors, and stem cells in the adult CNS

19 Axon guidance during development and regeneration

20 Synaptogenesis

Part B2. Determinants of regeneration in the injured nervous system

21 Inhibitors of axonal regeneration

22 Effects of the glial scar and extracellular matrix molecules on axon regeneration

23 Trophic factors and their influence on regeneration

24 Intraneuronal determinants of regeneration

Part B3: Promotion of regeneration in the injured nervous system

25 Cell replacement in spinal cord injury

26 Dysfunction and recovery in demyelinated and dysmyelinated axons

27 Role of Schwann cells in peripheral nerve regeneration

28 Transplantation of Schwann cells and olfactory ensheathing cells to promote regeneration in the CNS

29 Trophic factor delivery by gene

30 Assessment of sensorimotor function after spinal cord injury and repair

Part B4. Translational research: application to human neural injury

31 Alzheimer's disease, model systems and experimental therapeutics

32 Biomimetic design of neural prostheses

33 Brain-computer interfaces for communication and control

34 Status of neural repair clinical trials in brain diseases

Index.