Thiamine Deficiency and Associated Clinical Disorders

by Mccandless, David W.

• ISBN13: 9781607613107
• ISBN10: 1607613107
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-09-23
• Publisher: Humana Pr Inc

Summary

The past twenty years have seen remarkable advances in neuroscience, neurology, imaging techniques, and diagnostic strategies. These advances have been successfully applied to many different diseases, including thiamine deficiency and associated clinical disorders. Syndromes such as beriberi, Wernicke's disease, Leigh's disease, African Seasonal Ataxia, and various inherited ataxias, have all benefited from improved scientific approaches. Thiamine Deficiency and Associated Clinical Disorders represents an intriguing area of both basic and clinical investigation. Modern imaging and diagnostic strategies have facilitated the rapid treatment, and potential reversal of these clinical disorders. The fusion of laboratory and clinical knowledge serve as an example of how research can translate to successful treatment. This book is designed to bring together cogent results from both basic and clinical investigation. These data will be of interest to neurologists, internists, nutritionists, biochemists, neurochemists, neuroscientists, and many others with interest in thiamine deficiency. About the Author:Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He serves as Editor-in Chief of the journal Metabolic Brain Disease (Springer), now in its 25th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others.

Author Biography

Dr. David W. McCandles is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He serves as Editor-in Chief of the journal Metobolic Brain Disease (Springer), now in its 24th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University Scholl of Medicine. Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc, National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others. This is his fourth book.

Table of Contents

Early Chemistry	p. 1
Early Thiamine Deficiency	p. 9
Thiamine Deficiency in Mammals	p. 17
Beriberi	p. 31
Wernicke's Disease	p. 47
Central Pontine Myelinolysis, Alcoholic Cerebellar Degeneration, and Marchiafava-Bignami Disease	p. 65
Central Pontine Myelinolysis	p. 65
Alcoholic Cerebellar Degeneration	p. 72
Marchiafava-Bignami Disease	p. 75
Leigh's Disease	p. 81
African Seasonal Ataxia	p. 103
Inherited Ataxias	p. 113
Thiamine Deficiency in Serious Blness	p. 131
Beriberi	p. 131
Cancer	p. 132
Intensive Care Units	p. 133
Hematologic Tumors	p. 134
Gastrectomy	p. 134
5-Fluorouracil	p. 136
Wernicke's Disease and Gastrectomy	p. 139
HIV/AIDS	p. 140
Malaria	p. 141
Amyotrophic Lateral Sclerosis	p. 142
Alzheimer's Disease	p. 143
World Health Concerns	p. 145
Epilogue: Future Prospects	p. 151
Animal Models of Thiamine Deficiency	p. 151
Beriberi	p. 153
Wernicke's Disease	p. 154
CPM/ACD/MBD	p. 156
Leigh's Disease	p. 157
Inherited Ataxias	p. 158
Serious Illnesses and Thiamine Deficiency	p. 159
Conclusions	p. 160
Bontius Translation	p. 161
Thiamine Synonyms	p. 163
The Nobel Prize Acceptance Speech of Dr. Christiaan Eijkman, 1929	p. 165
References	p. 173
Index	p. 185
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