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Gregory J. del Zoppo, M.D. Professor of Medicine, Division of Hematology Adjunct Professor of Neurology University of Washington School of Medicine.
vii Introduction to Thrombolysis and Acute Stroke Treatment: Preparing for the Next Decade
Gregory J. del Zoppo and Andrei V. Alexandrov
1 Advanced multimodal CT/MRI approaches to hyperacute stroke diagnosis, treatment and monitoring
David S. Liebeskind and Andrei V. Alexandrov
8 The future of stroke thrombolysis
Antoine M. Hakim
14 Population shifts and the future of stroke: forecasts of the future burden of stroke
George Howard and David C. Goff
21 Pathobiology of injury after stroke: the neurovascular unit and beyond
Ulrich Dirnagl
26 The ischemic penumbra: how does tissue injury evolve?
Wolf-Dieter Heiss
35 Current treatment of basilar artery occlusion
Perttu J. Lindsberg, Tiina Sairanen, Daniel Strbian, and Markku Kaste
45 Improving public education about stroke
Mark J. Alberts
51 Impact of regional pre-hospital emergency medical services in treatment of patients with acute ischemic stroke
Cemal B. Sozener and William G. Barsan
57 Techniques for improving efficiency in the emergency department for patients with acute ischemic stroke
Edward C. Jauch, Christine Holmstedt, and Justin Nolte
63 Imaging-based selection in acute ischemic stroke trials- a quest for imaging sweet spots
Andrew M. Demchuk, Bijoy Menon, and Mayank Goyal
72 Considering hyperglycemia and thrombolysis in the Stroke Hyperglycemia Insulin Network Effort (SHINE) trial
Andrew M. Southerland and Karen C. Johnson
79 Treatment of acute ischemic stroke: systemic or local?
Rudiger von Kummer and Johannes Gerber
85 How baseline severity affects efficacy and safety outcomes in acute ischemic stroke intervention trials
Philip B. Gorelick
95 Does inhibiting Sur1 complement rt-PA in cerebral ischemia?
J. Marc Simard, Zhihua Geng, Frank L. Silver, Kevin N. Sheth, W. Taylor Kimberly, Barney J. Stern, Mario Colucci, and Volodymyr Gerzanich
108 Safety and efficacy of 0.6 mg/kg rt-PA: optimum rt-PA dose revisited
Etsuro Mori
113 Ancillary approaches to plasminogen activators
Reza Bavarsad Shahripour and Andrei V. Alexandrov
120 Selection of possible responders to thrombolytic therapy in acute ischemic stroke
Christian Hametner, Peter Arthur Ringleb, Werner Hacke, and Lars Kellert
127 Aging and the neurovascular unit
Gregory J. del Zoppo
134 Intra-arterial vasodilator use during endovascular therapy for acute ischemic stroke might improve reperfusion rate
Ziad M.K. El-Zammar, Julius Gene S. Latorre, Dongliang Wang, Shyama Satyan, Elwaleed Elnour, Adham Kamel, Ashok Devasenapathy, and Yahia M. Lodi
141 Timing of thrombolysis for acute ischemic stroke: “timing is everything” or “everyone is different”
James Grotta
145 Pre- and in-hospital intersection of stroke care
Atte Meretoja and Markku Kaste
152 A strategic plan to accelerate development of acute stroke treatments
John R. Marler
157 Corrigendum for Ann. N.Y. Acad. Sci. 2010. 1195. 1-27
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