Thrombosis and Hemorrhage

by Loscalzo, Joseph; Schafer, Andrew I.

• ISBN13: 9780781730662
• ISBN10: 078173066X
• Edition: 3rd
• Format: Hardcover
• Copyright: 2002-10-14
• Publisher: LWW

Summary

Now in its Third Edition, this authoritative text continues to provide a comprehensive and systematic review of the biology, pathobiology, and clinical disorders of the hemostatic system. Its unique organization of the basic sciences coupled with clinical sections yields a user-friendly integrated text, and a reference tool that meets the needs of diverse investigators and clinicians of contemporary medicine for understanding the hemostatic system. New chapter topics covered in this edition include angiogenesis and vasculogenesis; hemorrhagic complications of antithrombotic therapy; interactions of coagulation and fibrinolytic proteins with the vessel wall; and less common thrombotic disorders.

Table of Contents

Preface	xi
Acknowledgments	xiii
Contributors	xv
SECTION 1 COAGULATION AND FIBRINOLYSIS
Coagulation Cascade: An Overview	1	(21)
Nancy Swords Jenny
Kenneth G. Mann
Molecular Genetics of Blood Coagulation	22	(13)
Rodney M. Camire
Peter J. Larson
Katherine A. High
Regulation of Coagulation	35	(27)
Rachel E. Simmonds
James Rance
David A. Lane
The Tissue Factor Pathway of Coagulation	62	(19)
George J. Broze, Jr.
Fibrin Formation and Stabilization	81	(24)
Charles S. Greenberg
Thung-Shenq Lai
Regulation of Fibrinolysis	105	(15)
Douglas E. Vaughan
P.J. Declerck
SECTION 2 PLATELETS
Regulation of Megakaryopoiesis	120	(20)
Kenneth Kaushansky
Platelet Morphology and Shape Change	140	(21)
John H. Hartwig
Platelet Membranes and Receptors	161	(26)
Ellinor I.B. Peerschke
Jose A. Lopez
Mechanisms of Platelet Activation	187	(19)
Michael H. Kroll
Julio C. Resendiz
SECTION 3 VESSEL WALL
The Endothelium in Thrombosis and Hemorrhage	206	(14)
Katherine A. Hajjar
Angiogenesis and Hemostasis	220	(16)
Timothy Browder
Maria Rupnick
Vascular Response to Injury	236	(10)
Bradford C. Berk
von Willebrand Factor	246	(20)
Zaverio M. Ruggeri
Jerry Ware
David Ginsburg
Interactions of Coagulation and Fibrinolytic Proteins with the Vessel Wall	266	(12)
Mark B. Taubman
Endothelium-derived Vasoactive Factors	278	(16)
Douglas G. Johns
Richard A. Cohen
Rheology	294	(21)
Shih-Hsin Kao
Larry Vern McIntire
SECTION 4 CLINICAL APPROACH TO BLEEDING AND THROMBOSIS
Approach to Bleeding	315	(15)
Andrew I. Schafer
Approach to Thrombosis	330	(13)
Kenneth A. Bauer
Assessment of Peripheral Arterial and Venous Thrombosis	343	(20)
Mark A. Creager
Joshua A. Beckman
Laboratory Methods in Hemostasis	363	(61)
Paula L. Bockenstedt
SECTION 5 QUANTITATIVE PLATELET DISORDERS
Thrombotic Microangiopathies: Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome	424	(17)
Joel L. Moake
Kelty R. Baker
Alloimmune Thrombocytopenias	441	(16)
Peter J. Newman
Janice G. McFarland
Richard H. Aster
Drug-induced Thrombocytopenias	457	(19)
Keith R. McCrae
Douglas B. Cines
Immune Thrombocytopenic Purpura	476	(20)
Robert McMillan
Paul Imbach
Thrombocytosis	496	(11)
Tiziano Barbui
Guido Finazzi
SECTION 6 QUALITATIVE PLATELET DISORDERS
Congenital Disorders of Platelet Function	507	(18)
Corie N. Shrimpton
Robert K. Andrews
Jose A. Lopez
Michael C. Berndt
Acquired Disorders of Platelet Function	525	(14)
Andrew I. Schafer
SECTION 7 DISORDERS OF COAGULATION FACTORS AND FIBRINOLYSIS
von Willebrand Disease	539	(21)
William C. Nichols
Kathleen A. Cooney
David Ginsburg
Zaverio M. Ruggeri
Hemophilia---Factor VIII Deficiency	560	(15)
Donna M. DiMichele
Stephanie Seremetis
Other Coagulation Factor Deficiencies	575	(24)
Harold R. Roberts
Miguel A. Escobar
Factor VIII and Other Coagulation Factor Inhibitors	599	(12)
David Green
Antiphospholipid Syndrome and Lupus Anticoagulants	611	(17)
Jacob H. Rand
SECTION 8 THROMBOTIC DISORDERS
The Relationship Between Thrombosis and Atherosclerosis	628	(20)
Marc S. Eisenberg
LeRoy E. Rabbani
Joseph Loscalzo
Inherited and Acquired Hypercoagulable States	648	(37)
Kenneth A. Bauer
Clinical Manifestations of Endothelial Dysfunction	685	(22)
Noyan Gokce
Joseph A. Vita
SECTION 9 OTHER DISORDERS OF HEMOSTASIS
Less Common Thrombotic and Embolic Disorders	707	(56)
Barbara Voetsch
Vahid Afshar-Kharghan
Joseph Loscalzo
Andrew Schafer
Vascular Purpura and Diseases of Blood Vessels	763	(18)
Nigel S. Key
Martin D. Phillips
Moise L. Levy
Disseminated Intravascular Coagulation	781	(22)
Eliot C. Williams
Coagulopathy of Liver Failure and Vitamin K Deficiency	803	(13)
Jose Martinez
Carl Barsigian
Maternal Hemostasis: Coagulation Problems of Pregnancy	816	(24)
Bryan T. Oshiro
D. Ware Branch
Hemorrhage, Thrombosis, and Antithrombotic Therapy in Children	840	(25)
Paul Monagle
Maureen Andrew
Alan D. Michelson
Interaction of Blood and Artificial Surfaces	865	(21)
Brian Richard Smith
Henry M. Rinder
Christine S. Rinder
SECTION 10 MANAGEMENT OF BLEEDING
Platelet Transfusion Therapy	886	(11)
Scott Murphy
Plasma and Component Therapy	897	(18)
Katharine A. Downes
Ronald A. Sacher
Nontransfusional Hemostatic Agents	915	(14)
Pier Mannuccio Mannucci
SECTION 11 MANAGEMENT OF THROMBOSIS
Pharmacology of Antiplatelet Agents	929	(10)
Carlo Patrono
Pharmacology of Heparin-related Compounds and Coumarin Derivations	939	(10)
Jeffrey Ginsberg
The Pharmacology of Thrombolytic Agents	949	(29)
Jane A. Leopold
Joseph Loscalzo
New Antithrombotic Strategies	978	(18)
Jane E. Freedman
Joseph Loscalzo
Bleeding Complications of Antithrombotic Therapy	996	(7)
Gary E. Raskob
Wanda Kilzer
Antithrombotic Interventions in Cerebrovascular Disease	1003	(27)
Gregory J. del Zoppo
Antithrombotic Therapy in Ischemic Heart Disease	1030	(23)
Glenn N. Levine
John M. Buergler
Antithrombotic Therapy in Peripheral Vascular Disease	1053	(13)
Mark R. Jackson
G. Patrick Clagett
Anticoagulants in Atrial Fibrillation	1066	(11)
Michael D. Ezekowitz
Satish K. Surabhi
Prevention and Treatment of Venous Thromboembolic Disease	1077	(19)
Charles W. Francis
Gene Therapy of Thrombotic and Hemorrhagic Disorders	1096	(13)
Levent M. Akyurek
Elizabeth G. Nabel
Index	1109