Toxicology and Risk Assessment

by Greim, Helmut; Snyder, Robert

• ISBN13: 9780470868935
• ISBN10: 0470868937
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-03-17
• Publisher: Wiley-Interscience

Summary

This new book, written by two outstanding scientists in the field, describes the basic principles of toxic mechanisms and organ toxicity, providing detailed information on specific mechanisms or chemicals for exemplification. The goal is to provide sufficient information that the reader becomes familiar with the basic concepts in toxicology to enable him or her to understand the basic principles in toxicology and to evaluate the risks at given exposures. With this basic understanding the reader also will be able to critically evaluate the available information on a chemical and to identify data gaps. In addition to the introductory chapters the book will offer the following systematic information, presented in six special sections: Principles in Toxicology Organ Toxicology Methods in Toxicology Risk Assessment Risk Management Toxicity of Chemicals Fulfilling a demand for such a book, this will be a welcomed introductory text for students and non-experts alike to focus on and understand the principles of hazard identification and risk assessment of toxicants. Relevant to all those studying toxicology, biochemistry, biology, medicine and chemistry, as well as toxicologists in hospitals, universities and in industry.

Author Biography

Prof. Dr. Helmut Greim, Institut für Toxikologie und Umwelthygiene Technische Universität München, Germany

Table of Contents

Preface

List of Contributors

Introduction to the Discipline of Toxicology

Introduction

The Risk-Assessment Process

Toxicological Evaluation of New and Existing Chemicals

Summary

Principles

Toxicokinetics

Phase I Metabolism

Introduction

The Enzymes Involved in Phase I Metabolism

Phase III (Metabolism)

Summary

Drug Metabolism

Conjugation

Hydrolysis

Summary

Toxicogenetics

Cytotoxicity

Receptor-Mediated Mechanisms

Mixtures and Combinations of Chemicals

Chemical Carcinogenesis: Genotoxic and Nongenotoxic Mechanisms

Reproductive Toxicology

Ecotoxicology: Not just Wildlife Toxicology

Organ Toxicology

The Gastrointestinal Tract

The Liver

The Respiratory System

The Nervous System

Behavioral Neurotoxicology

The Skin

The Kidney and Urinary Tract

Toxicology of the Blood and Bone Marrow

Immunotoxicology

The Eye

The Cardiovascular System

Methods in Toxicology

OECD Test Guidelines for Toxicity Tests in vivo

Mutagenicity Tests in vivo

Introduction

Chromosomal Mutations in Somatic Cells

Gene Mutations in Somatic Cells

Chromosome Mutations in Germ Cells

Gene Mutations in Germ Cells

Summary

In vitro Tests for Genotoxicity

Introduction

Xenobiotic Metabolism in vitro

Test Systems Employing Bacteria

Test Systems Employing Mammalian Cells

Cell-Transformation Assays

Summary

Strategies for the Evaluation of Genotoxicity

Introduction

Basics of Genotoxicity Testing

Current Approaches for Assessing Genotoxicity

Summary

Biomonitoring

Epidemiology

Omics in Toxicology

Introduction to the Statistical Analysis of Experimental Data

Risk Assessment

Mathematical Models for Risk Extrapolation

Regulations Regarding Chemicals and Radionuclides in the Environment, Workplace, Consumer Products, Foods, and Pharmaceuticals

Toxicity of Selected Chemicals

Persistent Polyhalogenated Aromatic Hydrocarbons

Metals

Toxicology of Fibers and Particles

Xenoestrogens and Xenoantiandrogens

Toxicology of Solvents

Noxious Gases

Animal and Plant Toxins

Index

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