Trends in Gastroenterology and Hepatology

by Asakura, Hitoshi; Aoyagi, Y.; Nakazawa, Saburo; Nihon Shokakibyo Gakkai Sokai 2000 (Niigata-Shi, Japan)

• ISBN13: 9784431703020
• ISBN10: 4431703020
• Format: Hardcover
• Copyright: 2001-08-01
• Publisher: Springer Verlag

Summary

Niigata Univ., Japan. Proceedings of the 86th annual congress of the Japanese Society of Gastroenterology. Contains papers presented at the congress held in April 2000 in Niigata City, Japan. DNLM: Digestive System Diseases--Congresses.

Table of Contents

Preface	v
Contributors	xv
Part 1 Gastroenterology and the New Millennium
Reflecting Forward: Gastroenterology in the New Millennium	3	(12)
D.K. Podolsky
Part 2 Ulcerative Colitis Pathophysiology and Therapy
Pathophysiology of and New Treatment for Ulcerative Colitis	15	(12)
H. Asakura
Part 3 Life Style-Related Diseases and Gastroenterology
New Target of Gastroenterology: Overcoming Life Style-Related Diseases	27	(8)
S. Nakazawa
Part 4 Apoptosis in Digestive Organs
Examination of Cytotoxic T Lymphocyte-Mediated Apoptosis Pathway in Peptic Ulcer Formation with or without H. pylori Infection	35	(8)
T. Ohara
Y. Kanoh
T. Mashiko
S. Asaki
S. Kudoh
Epidermal Growth Factor Inhibits Helicobacter pylori Lipopolysaccharide-Induced Apoptosis of Primary Cultures of Gastric Pit Cells	43	(4)
T. Kawahara
S. Teshima
K. Kishi
K. Rokutan
Impaired Sensitivity to Fas-Induced Apoptosis of Lymphocytes in Ulcerative Colitis Lesions	47	(6)
H. Ueyama
T. Kiyohara
Y. Shinomura
Y. Matsuzawa
Tumor Necrosis Factor α-Induced Hepatic Apoptosis and Hepatocyte Sensitization	53	(6)
M. Nagaki
Y. Osawa
T. Naiki
H. Moriwaki
Molecular Mechanisms of D-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure in Mice and the Effects of Therapeutic Agents	59	(4)
S. Hirono
T. Nakama
H. Tsubouchi
Ethanol-Induced Apoptosis Mediated by Mitochondrial Permeability Transition in Primary Cultured Sinusoidal Endothelial Cells	63	(3)
T. Kitamura
L.X. Li
M. Hirose
K. Iejima
N. Enomoto
S. Matsuyama
Y. Takei
N. Sato
Therapeutic Strategies for Hepatocellular Carcinoma Based on Analyses for Resistance to Apoptosis Mediated by Activation of Intracellular Signal Pathways	66	(5)
T. Ito
Y. Sasaki
H. Yoshihara
K. Suzuki
E. Masuda
Y. Yamada
K. Arai
T. Kamada
N. Hayashi
J. R. Wands
Expression of Apoptosis-Related Factors in Human Pancreatic Duct Cell Carcinoma and Intraductal Papillary-Mucinous Tumor	71	(8)
K. Satoh
A. Masamune
K. Kaneko
M. Hirota
A. Satoh
T. Shimosegawa
Part 5 Is Nitric Oxide Friend or Foe?
Effect of Exogenous and Endogenous Nitric Oxide on Endothelial Permeability Induced by Oxidants In Vitro	79	(3)
N. Okayama
M. Itoh
J.S. Alexander
Gastric Carcinoma and Helicobacter pylori Infection: Role of Nitric Oxide and Inflammatory Cytokines in Gastric Carcinogenesis	82	(4)
Y. Kitadai
K. Haruma
T. Goto
K. Komoto
S. Tanaka
M. Yoshihara
K. Sumii
K. Chayama
Does Cyclooxygenase-2 Down-Regulate Gastric Inflammation?	86	(4)
S. Tsuji
W.-H. Sun
M. Tsujii
S. Kawano
M. Hori
Regulation of Mucin Synthesis by Neuronal Nitric Oxide Synthase in Gastric Pit Cells	90	(5)
K. Rokutan
S. Teshima
T. Kawai
T. Kawahara
K. Kusumoto
K. Kishi
Role of Nitric Oxide and Capsaicin-Sensitive Sensory Nerves in Gastric Receptive Relaxation and Adaptive Relaxation in Isolated Stomachs of Guinea Pigs	95	(4)
H. Uno
K. Higuchi
Role of Inducible Nitric Oxide Synthase in Murine Colitis	99	(4)
H. Ogawa
M. Yamamoto
H. Nakamura
H. Ito
Role of Nitric Oxide in the Progression of Severe Acute Pancreatitis	103	(3)
A. Satoh
A. Masamune
T. Shimosegawa
Role of Nitric Oxide in the Progression of Acute Pancreatitis	106	(6)
T. Nishino
S. Watanabe
H. Oyama
Y. Fukuya
N. Hayashi
M. Kobayashi
Protective Effect of Nitric Oxide on Acute Liver Failure in Rats	112	(3)
T. Kono
H. Kotani
T. Asama
N. Mamiya
N. Ando
N. Chisato
K. Kamiya
M. Yoneda
J. Iwamoto
S. Kasai
Regulatory Mechanism of Cationic Amino Acid Transporters in Hepatic Sinusoidal Ito Cells	115	(8)
T. Saibara
K. Ookawauchi
N. Akisawa
S. Iwasaki
T. Maeda
S. Onishi
Part 6 Transcription Factors in Digestive Organs
Novel NADPH Oxidase, Mox1, Expressed in Cultured Gastric Pit Cells: Modulation of NF-kB Activation	123	(5)
S. Teshima
T. Kawahara
K. Kishi
K. Rokutan
Role of PPARγ in the Growth and Differentiation of Gastric and Colorectal Cancers	128	(4)
Y. Miyazaki
S. Kitamura
Y. Shinomura
Y. Matsuzawa
PPARγ Ligand and Induction of Growth Arrest in Pancreatic Cancer Cells	132	(6)
A. Elnemr
T. Ohta
S. Fushida
I. Ninomiya
G. Nishimura
H. Kitagawa
M. Kayahara
T. Terada
K. Miwa
Role of β-Catenin During Early Colorectal and Hepatic Carcinogenesis	138	(4)
M. Murata
Y. Miyoshi
Growth Inhibition of Hepatoma Cells by Type 1 Interferons: Modification by Mutations in the Interferon Regulatory Factor-1 Gene	142	(5)
H. Saito
S. Tada
K. Wakabayashi
T. Takagi
N. Nakamoto
S. Kurita
H. Ishii
Growth Inhibition of Pancreatic Cancer Cell Lines by Ligand Activation of Nuclear Hormone Receptors Through Up-Expression of WAF1/CIP1/p21	147	(8)
S. Kawa
K. Kiyosawa
Part 7 The Role of Antigen-Presenting Cells in Pathophysiology
Immunopathological Features of Granuloma Formation in the Intestinal Mucosa of Patients with Crohn's Disease	155	(5)
T. Matsumoto
S. Nakamura
J. Hara
Y. Jinno
Y. Sawa
N. Oshitani
K. Higuchi
T. Arakawa
Y. Nishiguchi
K. Hirakawa
H. Otani
H. Nagura
Helicobacter pylori and N-Methyl-N-nitro-N-nitrosoguanidine Induction of Dendritic Cell Infiltration of the Pyloric Mucosa of Mongolian Gerbils	160	(7)
M. Oka
C. Furihata
M. Ichinose
N. Yahagi
Y. Shimizu
H. Kurakata
A. Tateishi-Niihata
M. Fujishiro
Y. Sakaki
M. Omata
Cytotoxic Effect of Bone Marrow-Derived Dendritic Cells	167	(4)
H. Shimamura
F. Motoi
J. Yamauchi
K. Shibuya
M. Sunamura
K. Takeda
S. Matsuno
Autoimmune Mechanisms of Cancer-Associated Paraneoplastic Syndromes: A Review	171	(4)
T. Nishida
Antitumor Activity Against Gastrointestinal and Hepatocellular Carcinoma Induced by Immunization with Fusion of Dendritic and Carcinoma Cells in Mice	175	(8)
S. Homma
T. Iinuma
G. Toda
T. Ohno
D. Kufe
Part 8 The Pathophysiology of Inflammatory Bowel Disease
Essential Role for Interleukin-6 in the Pathogenesis of Crohn's Disease	183	(4)
H. Ito
T. Kishimoto
Activation of Nuclear Factor kB in Dextran Sulfate Sodium-Induced Colitis in Mice and Their Inhibition by Phenyl N-tert-Butylnitrone	187	(6)
T. Takagi
Y. Naito
T. Yoshikawa
Y. Kotake
Essential Roles for Th2-Type Responses in Chronic Intestinal Inflammation	193	(4)
T. Dohi
Induction of Colitis and Exocrinopathy in Nude Mice Induced by Immunocompetent Cell Transfer from Murine Retrovirus-Infected Mice	197	(4)
K. Suzuki
Y. Baba
H. Suriki
H. Kawachi
F. Shimizu
H. Asakura
Potential Role of Mucosal Addressin Cell Adhesion Molecule-1 in Inflammatory Bowel Diseases	201	(4)
S. Kato
R. Hokari
S. Miura
Anti-Saccharmomyces cerevisiae Antibody in Inflammatory Bowel Disease	205	(3)
N. Oshitani
K. Higuchi
T. Matsumoto
T. Arakawa
Reactive Oxygen Species and Colonic Epithelial Cell Apoptosis in Ulcerative Colitis	208	(7)
A. Hayashi
T. Kitahora
H. Ono
Part 9 NSAID-Induced Gastric Lesions
Effect of Antiulcer Drugs for Treatment of Nonsteroidal Antiinflammatory Drug-Induced Ulcers	215	(4)
Y. Mizokami
T. Shiraishi
T. Otsubo
Y. Kariya
H. Nakamura
K. Narushima
T. Matsuoka
Role of Intravascular Neutrophils in the Pathogenesis of Aspirin-Induced Gastric Mucosal Injury	219	(5)
N. Yoshida
T. Yoshikawa
Mucin Secretion Evoked by Prostaglandin E2 in Guinea Pig Antral Mucous Cells: Role of EP1/EP4 Receptors	224	(5)
A. Ohnishi
C. Shimamoto
T. Nakahari
S. Fujiwara
Y. Nakahata
K. Kojima
K. Katsu
Effects of Indomethacin and NS-398 on Acid-Induced E-Cadherin Surface Expression in Rat Gastric Epithelial Cells	229	(4)
Y. Takezono
T. Joh
M. Sasaki
H. Kataoka
K. Senou
N. Okayama
Y. Yokoyama
M. Itoh
Roles of Reactive Nitrogen Species in Helicobacter-Related Carcinogenesis	233	(4)
S. Tsuji
A. Kimura
M. Hori
S. Kawano
Interaction Between Helicobacter pylori Infection and NSAID Use	237	(5)
A. Shiotani
D. Y. Graham
Interrelations of Nonsteroidal Antiinflammatory Drugs, H. pylori Infection, and Gastric Damage	242	(7)
S. Futagami
T. Hiratsuka
K. Wada
A. Tatsuguchi
T. Tsukui
K. Miyake
Y. Shinji
T. Iizumi
K. Shinoki
T. Akamatsu
M. Hosone
C. Sakamoto
M. Kobayashi
Part 10 Prevention of Disease by Modulation of Microcirculation
Microvascular Leukocyte Activation and Apoptosis in Helicobacter pylori-Colonized Gastric Mucosa	249	(8)
H. Suzuki
K. Yamabe
M. Miyazawa
S. Miura
M. Suzuki
H. Ishii
Alteration of Gastric Microcirculatory Architecture During Healing of Acetic Acid-Induced Ulcer and Helicobacter pylori Infection	257	(6)
M. Nakamura
H. Matsui
K. Tsuchimoto
H. Ishii
Cyclooxygenase and Colon Cancer	263	(4)
M. Tsujii
S. Tsuji
S. Kawano
Contribution of Colon Cancer Cells to Mesenchymal Cells in the Formation of Hepatic Metastasis	267	(5)
N. Yamada
S. Shimizu
S. Takatsuka
M. Yashiro
T. Sawada
M. Ohira
T. Ishikawa
H. Nishino
K. Kaneda
K. Hirakawa
Hepatic Microcirculation in Massive Liver Necrosis and Liver Regeneration	272	(5)
S. Mochida
K. Fujiwara
Prevention of Hepatic Ischemia/Reperfusion Injury by Microcirculatory Regulation: Application to Liver Transplantation	277	(6)
M. Shimazu
G. Wakabayashi
M. Tanabe
S. Kawachi
K. Iwata
M. Kitajima
Genetic Manipulation of Sinusoidal Endothelial Cells	283	(4)
Y. Takei
A. Maruyama
T. Akaike
N. Sato
Controlling Tumor Microenvironment by the Antiangiogenesis Strategy	287	(3)
M. Sunamura
D.G. Duda
L. Lozonschi
S. Libo
K. Takeda
S. Matsuno
Pancreatic Blood Flow in Chronic Alcoholic Pancreatitis	290	(7)
T. Tanaka
T. Fujii
Y. Matsugu
K. Dohi
Part 11 Hepatic Regeneration Udpate
The Role of Hepatic Oval Cells in Hepatic Regeneration: Possible Clinical Applications	297	(5)
S. Matsusaka
A. Toyosaka
Hepatoma-Derived Growth Factor: Involvement in Liver Development and Regeneration	302	(4)
H. Enomoto
Y. Kishima
K. Yoshida
H. Nakamura
Tumor Necrosis Factor and Liver Regeneration	306	(6)
Y. Yamada
N. Fausto
H. Moriwaki
Heparin-Binding EGF-Like Growth Factor: Hepatotrophic Factor in Liver Regeneration	312	(5)
S. Kiso
S. Tamura
S. Kawata
Effects of Growth Stimulatory and Inhibitory Factors on Signal Transduction of Cultured Rat Hepatocyte and the Regulation of Cyclin D1 Transcription	317	(4)
A. Moriuchi
A. Ido
S. Hirono
T. Nakama
M. Ochiai
T. Hori
K. Hayashi
H. Tsubouchi
Significance of the Relation Between Hepatocyte Growth Factor and Transforming Growth Factor-α in Hepatocyte Proliferation	321	(6)
T. Tomiya
K. Fujiwara
Part 12 Hepatic Fibrosis Research and Its Application to Therapy
Transcriptional Regulation of Type I Collagen Gene Expression by Transforming Growth Factor-β and Smad Proteins	327	(4)
Y. Inagaki
T. Nemoto
A. Nakao
Clinical Usefulness of Plasma MMP-9 Assay Compared with the Plasma MMP-2 Assay in Patients with Chronic Liver Disease	331	(5)
Y. Murawaki
Y. Ikuta
K. Okamoto
M. Koda
H. Kawasaki
Molecular Mechanisms of Matrix Metalloproteinase-1 Gene Expression in Hepatic Stellate Cells	336	(4)
S. Hozawa
H. Suzuki
S. Kagawa
A. Higuchi
T. Watanabe
H. Ishii
I. Okazaki
Molecular Analysis of Stellate Cells Activation by Proteomics	340	(4)
N. Kawada
Tissue Inhibitor of Metalloproteinase-1: Strong Promotion of Liver Fibrosis Develoment in the Transgenic Mouse Model	344	(6)
H. Yoshiji
S. Kuriyama
H. Fukui
Antioxidant and Antiapoptotic Activities of a Tissue-Specific Selective Estrogen Receptor Modulator, Idoxifene, in Rat Fibrotic Liver and Cultured Rat Hepatocytes	350	(6)
I. Shimizu
T. Omoya
Y. Zhou
M. Itonaga
H. Inoue
G. Lu
Y. Okamura
M. Shono
H. Honda
S. Ito
Blockade of TGFβ Signaling: Prevention of Fibrosis/Dysfunction and Enhancement of Hepatocyte Regeneration in Injured Liver	356	(5)
H. Ueno
T. Nakamura
Protease Inhibitors: Suppression of Activation of Hepatic Stellate Cells by Inhibiting TGFβ Generation	361	(3)
M. Okuno
K. Akita
S. Adachi
H. Moriwaki
S. Kojima
Plasma Transforming Growth Factor-β1: A Useful Marker for Hepatic Fibrosis in Chronic Hepatitis C	364	(3)
N. Ito
S. Kawata
Key Word Index	367