Uterine Cancer

by Luesley; David M.

• ISBN13: 9780824759513
• ISBN10: 0824759516
• Format: Hardcover
• Copyright: 2005-09-23
• Publisher: CRC Press

Summary

(Taylor & Francis) Third author, Andrew Burchuck, is with Duke Univ. Medical Center, Durham, NC. Reviews present knowledge in all aspects of uterine cancer with authoritative predictions on future directions in management. Discusses staging criteria, imaging techniques used in assessment and management, therapeutic regimens, HRT, and more. For researchers and clinicians.

Table of Contents

Preface	iii
Contributors	xi
1. Epidemiology	1	(12)
David M. Purdie
Incidence and Mortality	1	(1)
Cancer Subtypes	2	(1)
Risk Factors for Endometrial Cancer	2	(4)
References	6	(7)
2. Screening in Endometrial Cancer	13	(18)
Thomas Hogberg
What Does Cancer Screening Actually Mean?	13	(1)
Cancer Screening Traps	14	(1)
Screening for Endometrial Cancer?	15	(1)
Screening Tests for Endometrial Cancer	16	(2)
What Could Be Gained by Screening for Endometrial Cancer?	18	(1)
The Natural Course of Endometrial Cancer—Premalignant Conditions?	19	(3)
Risk Groups	22	(1)
Preliminary Screening Trials	22	(4)
Conclusions	26	(1)
References	26	(5)
3. Pathology of Endometrial Hyperplasia and Neoplasia	31	(22)
Terry Rollason and Raji Ganesan
Introduction	31	(3)
Endometrioid Carcinoma	34	(4)
Mucinous Carcinoma	38	(1)
Serous Carcinomas	39	(2)
Clear Cell Carcinoma	41	(1)
Mixed Carcinomas	42	(1)
Undifferentiated Carcinoma	43	(1)
Other Rare Types of Endometrial Carcinoma	43	(1)
Tumors Metastatic to the Endometrium	43	(6)
References	49	(4)
4. Pathology of Uterine Sarcoma	53	(16)
Nafisa Wilkinson
Introduction	53	(1)
Staging of Uterine Sarcomas	54	(1)
Endometrial Stromal Sarcoma	54	(4)
Immunohistochemistry of Uterine Sarcomas	58	(1)
Hormonal Aspects of Stromal Sarcomas	59	(2)
Myxoid Leiomyosarcoma	61	(1)
Epithelioid Leiomyosarcoma	62	(1)
Carcinosarcoma: A Metaplastic Carcinoma or Sarcoma?	62	(1)
Pure Sarcomas	63	(1)
Tamoxifen and its Role in Uterine Sarcoma	63	(1)
References.	63	(6)
5. The Molecular Genetics of Endometrial Cancer	69	(22)
G. Larry Maxwell, John I. Risinger, J. Carl Barrett, and Andrew Berchuck
Introduction	69	(1)
Somatic Genetic Alterations.	70	(6)
Hereditary Endometrial Cancer	76	(1)
Epigenetics in Endometrial Carcinoma	76	(4)
Microarray	80	(1)
Summary of the Molecular Biology of Endometrial Cancer	81	(2)
References	83	(8)
6. Clinical Presentation and Investigation: The "One-Stop" Clinic, Endometrial Sampling, Hysteroscopy, Vaginal Ultrasound	91	(16)
Christopher Lee and Davor Jurkovic
Introduction	91	(1)
Investigations	92	(5)
The Rapid Access Clinic	97	(3)
Conclusion	100	(1)
References	100	(7)
7. Imaging Endometrial Cancer	107	(24)
Moji Balogun and Julie Olliff
Magnetic Resonance Imaging	112	(14)
References	126	(5)
8. Surgery for Uterine Cancer	131	(18)
Neville F. Hacker and Donald E. Marsden
Endometrial Cancer	131	(2)
Prognostic Factors That May Help Determine the Appropriate Surgery for Endometrial Cancer	133	(3)
Diagnosis	136	(1)
Preoperative Work Up	137	(1)
The Surgical Procedure	137	(5)
Uterine Sarcomas	142	(2)
Summary	144	(1)
References	144	(5)
9. Risk Factors and the Role of Radiotherapy in the Treatment of Endometrial Cancer	149	(28)
Ida Ackerman and Helen Steed
History of Radiation	149	(1)
Staging and Prognostic Factors	150	(3)
Stage I Disease	153	(7)
Stage II Disease	160	(1)
Stage III and IV Disease	161	(4)
Palliative Radiotherapy	165	(1)
Uterine Papillary Serous Carcinoma	165	(1)
Uterine Sarcomas	166	(1)
Irradiation Technique and Dose	166	(1)
Radiotherapy Toxicity	167	(1)
Conclusions	168	(1)
References	168	(9)
10. Chemotherapy for Uterine Cancer	177	(22)
Kathryn F. Chrystal, Kerry A. Cheong, and Peter G. Harper
Introduction	177	(1)
Endometrioid Adenocarcinoma	178	(4)
Conclusion.	182	(1)
Serous Carcinoma	182	(2)
Uterine Sarcomas	184	(4)
Conclusions	188	(1)
References	188	(11)
11. Minimal Access Surgery in Endometrial Cancer	199	(12)
Robbert Soeters and Lynette Denny
Introduction	199	(1)
The Role of Vaginal Hysterectomy in the Management of Endometrial Cancer	200	(1)
Laparoscopic-Assisted Vaginal Hysterectomy (LAVH)	200	(1)
Laparoscopic Lymphadenectomy	201	(1)
Application of LAVH and Lymphadenectomy for Endometrial Cancer	201	(1)
Complications of Laparoscopy	202	(1)
Clinical Outcome of Laparoscopic Versus Open Abdominal Surgical Approach to Management of Endometrial Cancer	203	(1)
Cost Benefit of Laparoscopic Surgery	203	(1)
Contraindications to Laparoscopic Surgery for Treatment of Endometrial Cancer	204	(1)
Setting up for Laparoscopic Surgery	204	(1)
Laparoscopic Surgery	205	(3)
References	208	(3)
12. Follow-Up and Detection of Relapsed Disease in Uterine Cancer	211	(22)
Fabio Landoni, Angelo Maggioni, and Guilherme Cidade Crippa
Background	211	(2)
Patterns of Recurrence	213	(3)
Recurrence Risk Groups.	216	(2)
Prognosis After Recurrence	218	(2)
Detection and Surveillance	220	(8)
Conclusions	228	(3)
References	231	(2)
13. The Role of Surgery in Advanced and Relapsed Disease	233	(10)
J. Michael Straughn and Ronald D. Alvarez
Importance of Surgical Staging	233	(1)
Role of Radical Hysterectomy	234	(1)
Role of Primary Cytoreduction in Patients with Advanced Disease	235	(3)
Role of Secondary Cytoreduction in Patients with Relapsed Disease	238	(1)
Role of Pelvic Exenteration in Patients with Relapsed Disease	239	(1)
Conclusion	239	(1)
References	240	(3)
14. Endometrial Carcinoma and Hormone Replacement Therapy	243	(12)
Michael S. Marsh
Endometrial Cancer and Unopposed Estrogen Use	243	(1)
Vaginal Estrogen Treatment	244	(1)
The Addition of Progestogens	245	(3)
Tibolone and Endometrial Cancer Risk	248	(1)
Selective Estrogen Receptor Modulators (SERMs)	249	(1)
ERT Use in Women with Previous Endometrial Carcinoma.	249	(2)
Summary Points	251	(1)
References	251	(4)
15. Future Developments in Radiation Therapy for Endometrial Carcinoma	255	(12)
Carien L. Creutzberg and Jan G. Aalders
Reducing Indications for Pelvic Radiotherapy	256	(1)
The Role of Lymphadenectomy and Its Combination with Radiotherapy	257	(1)
The Increasing Use of Vaginal Brachytherapy Alone	258	(1)
The Use of Both Adjuvant Radiotherapy and Chemotherapy in High-Risk Disease	259	(2)
The Use of New RT Techniques to Reduce Morbidity	261	(1)
Conclusions	262	(1)
References	262	(5)
16. Future Directions: Chemotherapy and Novel Agents for Uterine Cancer	267	(14)
Stacy D. D'Andre and Karl C. Podratz
Introduction	267	(1)
Adjuvant Chemotherapy	268	(1)
Combined Modality Therapy: Radiosensitizing Chemotherapy	268	(1)
Chemotherapy for Advanced Disease	268	(2)
Paclitaxel	270	(1)
Topotecan	271	(1)
Doxil®	271	(1)
Docetaxel	271	(1)
Oxaliplatin	272	(1)
Novel Agents	272	(2)
Conclusions	274	(1)
References	274	(7)
17. Combined Therapy in Uterine Cancer: Future Directions	281	(10)
Howard D. Homesley
Whole Abdominal Radiation Versus Chemotherapy	281	(1)
High-Risk Stage I Endometrial Carcinoma	282	(1)
Hormonal Therapy	283	(2)
The GOG Chemotherapy Trials in Endometrial Cancer	285	(1)
Alternative Chemotherapy Combinations	285	(2)
Current GOG Combined Radiation and Chemotherapy Trial	287	(1)
Combined Hormonal, Chemotherapy, and Radiation Therapy	287	(1)
References	288	(3)
Index	291