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9783764358365

Valproate : A Drug for Epilepsy, Psychiatry and Beyond

by
  • ISBN13:

    9783764358365

  • ISBN10:

    376435836X

  • Format: Hardcover
  • Copyright: 1999-08-01
  • Publisher: Springer Verlag
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Summary

School of Veterinary Medicine, Hannover, Germany. Current review of valproate, including new hypotheses on its mechanisms of action, metabolism into active metabolites, distribution characteristics, adverse effects, and clinical uses. For neurologists, psychiatrists, and basis scientists working in epilepsy research.

Table of Contents

List of contributors
vii
Preface xi
Wolfgang Loscher
Foreword xiii
Roger J. Porter
The discovery of valproate
1(6)
Wolfgang Loscher
The pharmacology of valproate
Pharmacological effects and mechanisms of action
7(40)
Wolfgang Loscher
Chemistry and biotransformation
47(30)
Frank S. Abbott
M. Reza Anari
Absorption, distribution and excretion
77(14)
Danny D. Shen
Toxicity
91(40)
Matthias Radatz
Heinz Nau
Clinical use of valproate
Valproate in the treatment of epilepsies in children
131(22)
N. Sarisjulis
Olivier Dulac
Treatment of epilepsies in adults
153(14)
L. James Willmore
Valproate use in psychiatry: A focus on bipolar illness
167(36)
Robert M. Post
Valproate in the treatment of headache
203(20)
Stephen D. Silberstein
Adverse effects and interactions with other drugs
223(42)
Dieter Schmidt
The future of valproate
265(12)
Nathan B. Fountain
Fritz E. Dreifuss
Subject index 277

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