VASCULAR DEMENTIA

by Meyer, John; Rauch, Gaiane; Lechner, Helmut; Loeb, Carlo

• ISBN13: 9780879934255
• ISBN10: 0879934255
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-01-17
• Publisher: Wiley-Blackwell

Summary

Vascular dementia (VAD) accounts for one-third of all dementias in today's aging population, second only to Alzheimer's disease (DAT). Fortunately, current imaging techniques allow clinicians to view specific lesions in the brain, classify them by etiology and anatomical location, and assess changes using serial imaging, while at the same time correlating those changes with signs and symptoms of VAD or DAT. In 17 chapters, this book summarizes new concepts concerning the epidemiology, etiology, risk factors, neuropathology and pathogenesis of VAD and DAT, and mixtures of the two, and reviews their multiple causes, including microvascular and hemorrhagic lesions, and ischemic and inflammatory changes affecting both white and gray matter. For the first time, the subject of reversible cognitive decline among the elderly is described, and early control of vascular risk factors are described that can improve early cognitive decline and prevent strokes and dementia. Vascular dementia (VAD) accounts for one-third of all dementias in today's aging population, second only to Alzheimer's disease (DAT). Fortunately, current imaging techniques allow clinicians to view specific lesions in the brain, classify them by etiology and anatomical location, and assess changes using serial imaging, while at the same time correlating those changes with signs and symptoms of VAD or DAT. In 17 chapters, this book summarizes new concepts concerning the epidemiology, etiology, risk factors, neuropathology and pathogenesis of VAD and DAT, and mixtures of the two, and reviews their multiple causes, including microvascular and hemorrhagic lesions, and ischemic and inflammatory changes affecting both white and gray matter. For the first time, the subject of reversible cognitive decline is described in detail, and early control of vascular risk factors are discussed that can improve, prevent or reverse early cognitive decline and prevent strokes and dementia. Clinical features of patients with VAD are compared to those with DAT, so that similarities and differences in the clinical course of both diseases are apparent. Simple and practical methods for assessing and quantifying cognitive and neurobehavioral deteriorations are discussed, as well as issues for prevention and therapy. Neurologists, vascular surgeons, internists, family practitioners, nurses, rehabilitationists and clinical psychologists will all find this text practical, useful and informative.

Author Biography

Gotz Bertha, M.D. Institute for Clinical Neurophysiology and Neurorehabilitation, Graz, Austria David W. Desmond, Ph.D. Assistant Professor of Clinical Neuropsychology, Departments of Neurology and Pathology, State University of New York Health Science Center at Brooklyn, New York, USA Md. Anwarul Haque, M.D. Research Associate, Cerebrovascular Research Laboratories, Baylor College of Medicine, Veterans Administration Medical Center, Houston, Texas, USA Helmut Lechner, M.D. Professor of Neurology, Director, Institute for Clinical Neurophysiology and Neurorehabilitation, Graz, Austria Carlo Loeb, M.D. Professor of Neurology, Clinica Neurologica, Universita di Genova, Italy John Stirling Meyer, M.D. Professor of Neurology, Baylor College of Medicine, Director, Cerebrovascular Research Laboratories, Veterans Administration Medical Center, Houston, Texas, USA Jesus Porta-Etessam, M.D. Department of Neurology, Hospital Universitario "12 de Octubre", Madrid, Spain Alberto Portera-Sanchez, M.D., Ph.D. Professor of Neurology, Fundacion General U.C.M., Madrid, Spain Gaiane M. Rauch, M.D., Ph.D. Associate Director, Cerebrovascular Research Laboratories, Baylor College of Medicine, Veterans Administration Medical Center, Houston, Texas, USA Ronald A. Rauch, M.D. Assistant Professor of Radiology, Baylor College of Medicine, Director of Neuroradiology, Veterans Administration Medical Center, Houston, Texas, USA James F. Toole, M.D. President, World Federation of Neurology, Professor of Neurology, Director, Stroke Research Center, Wake Forest University, Medical Center Blvd., Winston-Salem, North Carolina, USA

Table of Contents

Contributors	p. iii
Foreword: Honorary editor	p. iv
Preface: Editors	p. vi
Epidemiology of Vascular Dementia	p. 1
Cardiovascular Risk Factors Contributing to Cerebral Degenerative Changes, Cognitive Decline, and Dementia	p. 19
Risk Factors for Vascular Dementia	p. 41
Neuropathological Correlates of Vascular Dementia	p. 59
Microvascular Pathology in Vascular and Related Dementias	p. 77
Recent Advances in Vascular Dementia Research	p. 101
Clinical Features of Patients with Vascular Dementia Versus Alzheimer's Disease	p. 119
Neuropsychological Assessments for Cognitive Decline	p. 131
Subcortical Arteriosclerotic Encephalopathy Binswanger Type or Chronic Microvascular Leukoencephalopathy Syndrome	p. 155
Criteria for Diagnosis of Vascular Dementia	p. 181
Classification of Subtypes of Vascular Dementia Including Subcortical Versus Cortical Dementias	p. 203
Neuroimaging in Vascular Dementia	p. 221
Clinical Observation During Long-Term Follow-Up of Outcome in Vascular Dementia	p. 235
Prevention and Treatment of Vascular Dementia	p. 251
Scientific Basis for Plasmapheresis in Vascular Dementia	p. 263
Estrogen Therapy for Prevention of Dementia in Postmenopausal Women	p. 279
Factors Influencing Long-Term Survival Among Patients with Vascular Dementia Versus Alzheimer's Disease	p. 289
Index	p. 307
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