Viral Hepatitis

by Thomas, Howard C.; Lemon, Stanley; Zuckerman, Arie J.

• ISBN13: 9781405130059
• ISBN10: 1405130059
• Edition: 3rd
• Format: Hardcover
• Copyright: 2005-09-05
• Publisher: Wiley-Blackwell

Summary

There has been an explosion of both the incidence and medical knowledge of viral hepatitis over the last two decades. The incidence of infection and disease is continuing to increase dramatically. The CDC estimates that 93,000 people in the US were infected with Hepatitis A during 2001 and that 31.3% of the US population have been infected at some point. Similarly, there are now estimated to be 1.25million people in the US who are chronically infected with Hepatitis B, resulting in 5,000 deaths per year. For Hepatitis C, the figures are 2.7 million people infected in the US, resulting in 8,000-10,000 deaths per year. Not only is the incidence of infection and disease increasing, but new Hepatitis viruses have been discovered, as well as the launch of new pharmaceutical products. Viral Hepatitis by Zuckerman & Thomas was the first comprehensive book on hepatitis and it is recognised as the standard reference text in this field. It was previously published by Churchill Livingstone (for two editions), but has now joined the Blackwell gastroenterology and hepatology list of books. The Editors are joined by a North American co-Editor for this edition - Professor Stanley Lemon of the University of Texas, Galveston, TX, USA. The new third edition is entirely revised and updated to cover the recent advances in diagnosis and treatment.

Author Biography

Professor Howard Thomas, Department of Medicine, St Mary's Hospital Medical School, London

Professor Arie Zuckerman, The Dean's Office, Royal Free School of Medicine, London

Professor Stanley Lemon, Dean of Medicine, Departments of Microbiology & Immunology and Internal Medicine, University of Texas Medical Branch, Texas

Table of Contents

Preface	vii
Contributors	ix
Section I, Introduction to Liver Biology
Liver stem cells in persistent viral infection, liver regeneration and cancer	3	(12)
Stuart Forbes
Malcolm Alison
Hepatic immunology	15	(18)
Cliona O'Farrelly
Robert H Pierce
Nicholas Crispe
Section II, Clinical Aspects of Viral Hepatitis
Clinical features of hepatitis	33	(17)
Arie Regev
Eugene R Schiff
Diagnostic approach to viral hepatitis	50	(15)
Julie C Servoss
Lawrence S Friedman
Jules L Dienstag
Evolution of hepatitis viruses	65	(14)
Peter Simmonds
Section III, Hepatitis A Virus
Structure and molecular virology	79	(13)
Stanley M Lemon
Annette Martin
Epidemiology	92	(17)
Mike G Catton
Stephen A Locarnini
Natural history and experimental models	109	(17)
Robert H Purcell
Suzanne U Emerson
Prevention	126	(23)
Beth P Bell
Section IV, Hepatitis B Virus and Other Hepadnaviridae
Structure and molecular virology	149	(32)
Michael Kann
Wolfram H Gerlich
Epidemiology	181	(12)
Daniel Lavanchy
Avihepadnaviridae	193	(17)
Allison R Jilbert
Stephen A Locarnini
Woodchuck hepatitis virus	210	(15)
Michael Roggendorf
Michael Lu
Hepatitis B surface antigen (HBsAg) variants	225	(17)
William F Carman
Mohammad Jazayeri
Ashraf Basuni
Howard C Thomas
Peter Karayiannis
Molecular variations in the core promoter, precore and core regions of hepatitis B virus, and their clinical significance	242	(21)
Peter Karayiannis
William F Carman
Howard C Thomas
Natural history of chronic hepatitis B and hepato-cellular carcinoma	263	(6)
Massimo Colombo
Pietro Lampertico
Hepatocellular carcinoma: molecular aspects in hepatitis B	269	(26)
Marie Annick Buendia
Patricia Paterlini-Brechot
Pierre Tiollais
Christian Brechot
Murine models and hepatitis B virus infection	295	(13)
David R Milich
Pathogenesis of chronic hepatitis B	308	(15)
Mark R Thursz
Howard C Thomas
Treatment of chronic hepatitis B	323	(14)
Patrick Marcellin
Tarik Asselah
Nathalie Boyer
Management of drug-resistant mutants	337	(8)
Yun-Fan Liaw
Liver transplantation in the management of chronic viral hepatitis	345	(25)
Marina Berenguer
Teresa L Wright
Prevention	370	(11)
Jane N Zuckerman
Section V, Hepatitis C Virus
Structure and molecular virology	381	(26)
Michael J McGarvey
Michael Houghton
Epidemiology	407	(19)
Josep Quer
Juan I Esteban Mur
The immune response to hepatitis C virus in acute and chronic infection	426	(13)
Khadija Iken
Margaret J Koziel
Natural history and experimental models	439	(29)
Patrizia Farci
Jens Bukh
Robert H Purcell
Autoimmune disorders	468	(14)
Elmar Jaeckel
Michael P Manns
Central nervous system complications	482	(14)
Daniel M Forton
Simon D Taylor-Robinson
I Jane Cox
Howard C Thomas
In vitro replication models	496	(15)
Ralf Bartenschlager
Sandra Sparacio
Progression of fibrosis	511	(9)
Thierry Poynard
Vlad Ratziu
Yves Benhamou
Dominique Thabut
Joseph Moussalli
The natural history of hepatitis C and hepatocellular carcinoma	520	(6)
Edward Tabor
Treatment of chronic hepatitis C	526	(14)
Jenny Heathcote
Janice Main
New drugs for the management of hepatitis C	540	(13)
John G McHutchison
Jennifer M King
Amany Zekry
Prevention	553	(18)
Sergio Abrignani
Grazia Galli
Michael Houghton
Section VI, Hepatitis D Virus
Structure and molecular virology	571	(12)
Michael MC Lai
Epidemiology and natural history	583	(10)
Floriano Rosina
Mario Rizzetto
Treatment	593	(10)
Grazia Anna Niro
Floriano Rosina
Mario Rizzetto
Section VII, Hepatitis E Virus
Structure and molecular virology	603	(8)
David A Anderson
R Holland Cheng
Hepatitis E as a zoonotic disease	611	(13)
Xiang-Jin Meng
Epidemiology, clinical and pathologic features, diagnosis, and experimental models	624	(11)
Kris Krawczynski
Rakesh Aggarwal
Saleem Kamili
Prevention	635	(16)
Robert H Purcell
Suzanne U Emerson
Section VIII, Clinical Aspects of Viral Liver Disease
Aetiology of fulminant hepatitis	651	(15)
Kittichai Promrat
Jack R Wands
Treatment of fulminant hepatitis	666	(16)
Kinan Rifai
Hans L Tillmann
Michael P Manns
Hepatitis and haemophilia	682	(11)
Christine A Lee
Occupational aspects of hepatitis	693	(21)
William L Irving
Kit Harling
Neonatal and paediatric infection	714	(26)
Deirdre Kelly
Elizabeth Boxall
Management of hepatocellular cancer	740	(15)
Helen L Reeves
Jordi Bruix
Application of molecular biology to the diagnosis of viral hepatitis	755	(14)
Jean-Michel Pawlotsky
Hepatitis in HIV-infected persons	769	(11)
Janice Main
Brendan McCarron
Treatment of extrahepatic diseases caused by hepatitis B and hepatitis C viruses	780	(14)
Philippe Merle
Christian Trepo
The histologist's role in the diagnosis and management of chronic hepatitis B and C	794	(10)
Robert Goldin
Geoffrey M Dusheiko
Disinfection and sterilization	804	(11)
Martin S Favero
Walter W Bond
Mechanisms of interferon resistance	815	(9)
Darius Moradpour
Markus H Heim
Hubert E Blum
New in vitro testing systems for hepatitis B and C viruses	824	(17)
David Durantel
Olivier Hantz
Christian Trepo
Fabien Zoulim
New vaccine technologies and the control of viral hepatitis	841	(10)
Colin R Howard
Safety of hepatitis B vaccines	851	(3)
Arie J Zuckerman
Before and since the discovery of Australia antigen: a chronological review of viral hepatitis	854	(11)
Philip P Mortimer
Arie J Zuckerman
Index	865