Viral Pathogenesis and Immunity

by Nathanson, Neal

• ISBN13: 9780781711036
• ISBN10: 0781711037
• Edition: 2nd
• Format: Paperback
• Copyright: 2001-12-01
• Publisher: LIPPINCOTT WILLIAMS & WILKINS

Summary

Based on the highly successful reference work Viral Pathogenesis, this concise version can be used as an introductory text or for self-education by medical students and biologists alike. This latest edition provides a completely revised overview of the subject with new chapters on innate immunity, emerging viral diseases, and antiviral therapy. Information is presented in a format that is easy to understand with copious examples that illustrate the experimental basis of important generalizations. Used by the lead author in his graduate classes, it sets forth essential principles and discusses the role of immunity and other host defenses. The book explains how viral pathogenesis can be used for the rational development of treatment and prevention of viral diseases. The only introductory text devoted exclusively to this topic. Focuses specifically on viral pathogenesis unlike other texts where only a few chapters are devoted to the topic, A 20% expansion over the first edition, Now in four color throughout! Book jacket.

Author Biography

Neal Nathanson is emeritus Professor and Chair of the Department of Microbiology

Table of Contents

I. ESSENTIALS OF PATHOGENESIS
Historical Roots	3	(9)
The Sequential Steps in Viral Infection	12	(13)
entry, dissemination, shedding, and transmission of viruses
Viral Tropism and Cellular Receptors	25	(13)
the localization of viruses to specific cells and tissues, and the determinants of virus tropism with particular attention to the role of cellular receptors
Virus-Cell Interactions	38	(15)
the effects of viral infection on cellular function including mechanisms of cell death, alterations of luxury functions, and commensalism; the influence of the host cell on virus replication ranging from permissive to restricted or latent infection
II. HOST RESPONSE TO VIRAL INFECTION
Immune Responses to Viral Infections	53	(17)
innate immunity, interferon, NK cells, complement, natural antibodies; viral immunology, the role of CD4 and CD8 cells, and the production of antibodies and virus-specific effector cells; the role of immune response in recovery from primary infection and protection against reinfection
Virus-Induced Immunopathology	70	(12)
role of the immune response in the production of viral disease, both antibody-mediated and cell-mediated; virus-initiated autoimmunity
Virus-Induced Immunosuppression	82	(17)
how viruses suppress the immune response, viral destruction of lymphoreticular cells, virus-induced tolerance, and examples of immunosuppression
III. VIRUS-HOST INTERACTIONS
Viral Virulence	99	(15)
measurement of virus virulence, selection of attenuated viruses, pathogenic mechanisms of virulence, genetics of virus virulence, and viral virulence genes of cellular origin, including viroceptors and virokines
Viral Persistence	114	(16)
the forms of virus persistence including highly productive infections, latency, and smoldering infections; mechanisms of escape from immune surveillance; selected examples
Viral Oncogenesis: Retroviruses	130	(12)
various mechanisms of retroviral oncogenesis, including oncogenes, nonacute transformation by insertional activation, and trans-acting accessory genes; examples
Viral Oncogenesis: DNA Viruses	142	(16)
tumor suppressor genes; mechanisms of transformation, including inhibition of tumor suppressor pathways, cellular immortalization, and transformation; examples of small and large oncogenenic DNA viruses
Host Susceptibility to Viral Diseases	158	(12)
genetic differences, particularly in mice, in susceptibility to specific viruses; non-immune and immune mechanisms of resistance and susceptibility; determinants of susceptibility in humans
HIV and AIDS	170	(19)
HIV receptors and co-receptors, CD4 T lymphocytes and macrophages as target cells, direct and indirect destruction of T lymphocytes; transmission of HIV; sequential steps in infection and disease evolution; static and dynamic aspects of virus replication and cellular replacment; HIV; variation; mechanisms of CD4 depletion and of immunosuppression
IV. PREVENTION OF VIRAL INFECTIONS
Viral Vaccines	189	(22)
viral pathogenesis and immune protection; comparison of vaccine modalities, including inactivated and attenuated virus vaccines, and newer vectors such as recombinant viruses and naked DNA; mechanisms of protection by established vaccines; roles of antibody and cellular immunity; the correlates of protection; sterilizing immunity vs partial protection; and challenges for an AIDS vaccine
Glossary	211	(4)
Subject Index	215