Virology : Principles and Applications

by John Carter (Liverpool John Moores University, UK); Venetia Saunders (Liverpool John Moores University, UK)

• ISBN13: 9780470023877
• ISBN10: 0470023872
• Edition: 1st
• Format: Paperback
• Copyright: 2007-08-01
• Publisher: WILEY

Summary

Virology: Principles and Applications is a clear and accessible introduction to this fast-moving field, providing a comprehensive resource enabling the reader to understand the key concepts surrounding this exciting subject. The reader is introduced to the principles of virus structure, replication and genetics, along with the theories behind the origins of viruses and how they are evolving. Taking a modern approach to the subject, the relevance of virology to everyday life is clearly emphasized and discussions of emerging viruses, cancer, vaccines, anti-viral drugs and gene vectors are included. To enhance student understanding, learning outcomes, sources of further information and at-a-glance sections are integrated into in each chapter, reinforcing key concepts.Illustrated in full color throughout, extensive use is made of clear diagrams that include standard color coding for different types of molecule, enabling students to grasp difficult concepts and deal with the level of detail in the subject.An invaluable text for students of biology, microbiology, molecular biology and biomedical sciences taking courses in virology. The book is also a useful resource for MSc level students looking for an accessible introduction to the subject.a student-friendly introduction to the fast-moving subject of virology introduces the relevance of virology to the modern world including latest developments in the field looks at topical viruses such as HIV and influenza virus illustrated in full color throughout with diagrams labeled clearly to enhance student understanding provides a comprehensive Virologists Vocabulary The companion web site www.wiley.com/go/carter provides self-assessment questions and answers, additional reference sources and links to various virology web sites

Table of Contents

Preface

Abbreviations used in this book

Greek letters used in this book

Colour coding for molecules

Viruses and their importance

Viruses are ubiquitous on Earth

Reasons for studying viruses

The nature of viruses

The remainder of the book

Methods used in virology

Introduction to methods used in virology

Cultivation of viruses

Isolation of viruses

Centrifugation

Structural investigations of cells and virions

Electrophoretic techniques

Detection of viruses and virus components

Infectivity assays

Virus genetics

Virus structure

Introduction to virus structure

Virus genomes

Virus proteins

Capsids

Virion membranes

Occlusion bodies

Other virion components

Virus transmission

Introduction to virus transmission

Transmission of plant viruses

Transmission of vertebrate viruses

Transmission of invertebrate viruses

Permissive cells

Attachment and entry of viruses into cells

Overview of virus replication

Animal viruses

Bacteriophages

Transcription, translation and transport

Introduction to transcription, translation and transport

Transcription of virus genomes

Transcription in eukaryotes

Translation in eukaryotes

Transport in eukaryotic cells

Transcription and translation in bacteria

Virus genome replication

Overview of virus genome replication

Locations of virus genome replication in eukaryotic cells

Initiation of genome replication

Polymerases

DNA replication

Double-stranded RNA replication

Single-stranded RNA replication

Reverse transcription

Assembly and exit of virions from cells

Introduction to assembly and exit of virions from cells

Nucleocapsid assembly

Formation of virion membranes

Virion exit from the infected cell

Outcomes of infection for the host

Introduction to outcomes of infection for the host

Factors affecting outcomes of infection

Non-productive infections

Productive infections

Classification and nomenclature of viruses

History of virus classification and nomenclature

Modern virus classification and nomenclature

Baltimore classification of viruses

Herpesviruses (and other dsDNA viruses)

Introduction to herpesviruses

The human herpesviruses

The herpesvirus virion

HSV-1 genome organization

HSV-1 replication

Latent herpesvirus infection

Other dsDNA viruses

Parvoviruses (and other ssDNA viruses)

Introduction to parvoviruses

Examples of parvoviruses

Parvovirus virion

Parvovirus replication

Other ssDNA viruses

Reoviruses (and other dsRNA viruses)

Introduction to reoviruses

Rotavirus virion

Rotavirus replication

Other dsRNA viruses

Picornaviruses (and other plus-strand RNA viruses)

Introduction to picornaviruses

Some important picornaviruses

The picornavirus virion

Picornavirus replication

Picornavirus recombination

Picornavirus experimental systems

Other plus-strand RNA viruses

Rhabdoviruses (and other minus-strand RNA viruses)

Introduction to rhabdoviruses

Some important rhabdoviruses

The

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