Virulence Mechanisms of Bacterial Pathogens

by Brogden, Kim A.; Roth, James A.; Stanton, Thaddeus B.; Bolin, Carole A.; Minion, F. Chris

• ISBN13: 9781555811747
• ISBN10: 1555811744
• Edition: 3rd
• Format: Hardcover
• Copyright: 2000-05-01
• Publisher: Amer Society for Microbiology

Summary

The third edition of this widely used reference book provides an overview of current knowledge of the wide variety of mechanisms used by bacterial pathogens in establishing infection, producing disease, and persisting in the host. The overall emphasis is to understand the mechanisms of host-pathogen interactions rather than to focus on specific research approaches. Internationally recognized authorities in the field review ongoing concepts in bacterial invasion, colonization, and survival; bacterial evasion of host defense mechanisms; bacterial effects on host cell function; and identification, regulation, and transfer of virulence genes.

Table of Contents

Organizing Committee	ix
Contributors	xi
Preface	xv
Acknowledgments	xvii
I. BACTERIAL INVASION, COLONIZATION, AND SURVIVAL	1	(104)
James A. Roth
Thaddeus B. Stanton
Bacterial Adherence, Colonization, and Invasion of Mucosal Surfaces	3	(16)
John H. Brumell
B. Brett Finlay
Bacterial Evasion of Host-Derived Antimicrobial Peptides on Mucosal Surfaces	19	(22)
Kim Alan Brogden
Consequences of Bacterial Invasion into Nonprofessional Phagocytic Cells	41	(20)
Jeffrey B. Lyczak
Gerald B. Pier
Ecological Aspects of Host Colonization: Coaggregation, Osmoadaptation, and Acid Tolerance or Resistance	61	(16)
Thad Stanton
Relationships between Community Behavior and Pathogenesis in Pseudomonas aeruginosa	77	(16)
Matthew R. Parsek
E. P. Greenberg
Antibiotic Resistance and Survival in the Host	93	(12)
Emma L. A. Macfarlane
Robert E. W. Hancock
II. BACTERIAL EVASION OF HOST DEFENSE MECHANISMS	105	(56)
Carole A. Bolin
What Is the Very Model of a Modern Macrophage Pathogen?	107	(12)
David G. Russell
Bacterial Resistance to Antibody-Dependent Defenses	119	(12)
Lynette B. Corbeil
Mechanisms of Resistance to NO-Related Antibacterial Activity	131	(12)
Andres Vazquez-Torres
Ferric C. Fang
DNA Repair and Mutators: Effects on Antigenic Variation and Virulence of Bacterial Pathogens	143	(18)
Thomas A. Cebula
J. Eugene LeClerc
III. BACTERIAL EFFECTS ON HOST CELL FUNCTION	161	(64)
Michael J. Wannemuehler
Bacterial Toxins in Disease Production	163	(12)
Joseph T. Barbieri
Kristin J. Pederson
Exploitation of Mammalian Host Cell Function by Shigella spp.	175	(14)
Larean D. Brandon
Marcia B. Goldberg
Bacterial Induction of Cytokine Secretion in Pathogenesis of Airway Inflammation	189	(14)
Alice Prince
The Type III Secretion Pathway: Dictating the Outcome of Bacterial-Host Interactions	203	(22)
Raymond Schuch
Anthony T. Maurelli
IV. IDENTIFICATION, REGULATION, AND TRANSFER OF VIRULENCE GENES	225	(38)
F. Chris Minion
Impact of Horizontal Gene Transfer on the Evolution of Salmonella Pathogenesis	227	(14)
Robert A. Kingsley
Renee M. Tsolis
Stacy M. Townsend
Tracy L. Norris
Thomas A. Ficht
L. Garry Adams
Andreas J. Baumler
Regulation of Virulence Gene Expression In Vivo	241	(10)
James M. Slauch
Identification of Virulence Genes In Silico: Infectious Disease Genomics	251	(12)
George M. Weinstock
Steven J. Norris
Erica J. Sodergren
David Smajs
V. CONCLUDING PERSPECTIVE	263	(20)
Kim A. Brogden
State and Future of Studies on Bacterial Pathogenicity: Impact of New Methods of Studying Bacterial Behavior In Vivo	265	(18)
H. Smith
Index	283