Clinical Pharmacokinetics Concepts and Applications

by Rowland, Malcolm; Tozer, Thomas

• ISBN13: 9780683074048
• ISBN10: 0683074040
• Edition: 3rd
• Format: Paperback
• Copyright: 1995-10-01
• Publisher: LWW

Summary

Since pharmacokinetics can greatly affect how different patients respond to the same drug, both students and physicians need a basic clinical understanding of this vital area. The Third Edition of Clinical Pharmacokinetics provides a practical perspective, with these added features considerations of both stereochemistry and the increasing number of polypeptide and protein drugs being developed; the range and number of problems at the end of each chapter has been expanded; a second color added to make the text more user friendly; important equations highlighted by shading. Compatibility: BlackBerry OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC

Table of Contents

Definitions of Symbols	xi
Why Clinical Pharmacokinetics?	1	(10)
Section I. Absorption and Disposition Kinetics
Basic Considerations	11	(7)
Intravenous Dose	18	(16)
Extravascular Dose	34	(19)
Section II. Therapeutic Regimens
Therapeutic Response and Toxicity	53	(13)
Constant-Rate Regimens	66	(17)
Multiple-Dose Regimens	83	(26)
Section III. Physiologic Concepts and Kinetics
Movement Through Membranes	109	(10)
Absorption	119	(18)
Distribution	137	(19)
Elimination	156	(28)
Integration With Kinetics	184	(19)
Section IV. Individualization
Variability	203	(17)
Genetics	220	(10)
Age and Weight	230	(18)
Disease	248	(19)
Interacting Drugs	267	(23)
Concentration Monitoring	290	(23)
Section V. Selected Topics
Distribution Kinetics	313	(27)
Pharmacologic Response	340	(27)
Metabolite Kinetics	367	(27)
Dose and Time Dependencies	394	(30)
Turnover Concepts	424	(19)
Dialysis	443	(64)
Seleted Reading	463	(6)
Appendix I. Additional Concepts And Derivations
A. Assessment of AUC	469	(4)
B. Estimation of Elimination Half-life From Urine Data	473	(5)
C. Estimation of Absorption Kinetics From Plasma Concentration Data	478	(7)
D. Mean Residence Time	485	(5)
E. Amount of Drug in Body on Accumulation to Plateau	490	(4)
F. Distribution of Drugs Extensively Bound to Plasma Proteins	494	(8)
G. Blood to Plasma Concentration Ratio	502	(2)
H. Estimation of Creatinine Clearance Under Nonsteady-State Conditions	504	(3)
Appendix II. Answers to Problems	507	(79)
Index	586