Mechanisms of Microbial Disease

by Schaechter, Moselio

• ISBN13: 9780683076059
• ISBN10: 0683076051
• Format: Paperback
• Copyright: 1998-08-01
• Publisher: Williams & Wilkins

Summary

Tufts Univ., Boston, MA. Text of medical microbiology and infectious disease for medical students. Includes case studies, key concepts, review questions with answers, review charts of infectious agents, and halftone and two-tone illustrations. Previous edition: c1993. Softcover. DNLM: Communicable Diseases--microbiology- biology

Author Biography

David W. K. Acheson, M.D. Assistant Professor, Department of Medicine Tufts University School of Medicine and Division of Geographic Medicine and Infectious Diseases New England Medical Center Elliott J. Androphy, M.D. Professor, Departmentof Dermatology Tufts University School of Medicine George M. Baer, D.V.M. Director, Laboratories Baer Colonia Condesa, Mexico Formerly with Department of Health and Human Services Centers for Disease Control Neil L. Barg, M.D. Associate Professor, Division of Infectious Diseases Department of Internal Medicine University of Michigan Medical School Michael Barza, M.D. Professor, Department of Medicine Tufts University School of Medicine and Division of Geographic Medicine and Infectious Diseases New England Medical Center Martin J. Blaser, M.D. Addison B. Scoville Professor and Director, Division of Infectious Diseases, Department of Medicine Professor of Microbiology and Immunology Vanderbilt University School of Medicine and Veterans Affairs Medical Center Suzanne F. Bradley, M.D. Associate Professor, Department of Internal Medicine Faculty Associate, Institute of Gerantology University of Michigan Medical School Staff Physician Veterans Affairs Medical Center Daniel K. Braun, M.D. Ph.D. Clinical Research Physician Infectious Diseases Therapeutics Lilly Research Laboratories John M. Coffin, Ph.D. Professor, Department of Molecular Biology and Microbiology Tufts University School of Medicine Victor J. DiRita, Ph.D. Associate Professor, Laboratory Animal Medicine Unit and Department of Microbiology and Immunology University of Michigan Medical School Barry I. Eisenstein, M.D. Vice President for Research Beth Israel-Deaconess Medical Center Professor, Department of Microbiology and Molecular Genetics Harvard Medical School N. Cary Engleberg, M.D. Professor, Departments of Internal Medicine and Microbiology and Immunology University of Michigan Medical School Roger G. Faix, M. D. Professor, Department of Pediatrics and Communicable Diseases Division of Pediatric Infectious Disease University of Michigan Medical School Ann Arbor and Mott Children's Hospital Bernard N. Fields, M.D (deceased) Formerly, Professor Harvard Medical School Janet R. Gilsdorf, M.D. Professor, Department of Pediatrics and Communicable Diseases Division of Pediatric Infectious Disease University of Michigan Medical School Ann Arbor and Mott Children's Hospital Sherwood L. Gorbach, M.D. Professor, Department of Community Medicine Tufts University School of Medicine Penelope J. Hitchcock, D.V.M. Chief, Sexually Transmitted Diseases Branch National Institutes of Health National Institute of Allergy and Infectious Diseases James M. Hughes, M.D. Director, National Center for Infectious Diseases Centers for Disease Control and Prevention Adolf W. Karchmer, M.D. Professor Harvard Medical School Chief, Infectious Diseases New England Deaconess Hospital Gary Ketner, Ph.D. Professor, Department of Molecular Microbiology and Immunology The Johns Hopkins University, School of Public Health Gerald T. Keusch, M.D. Professor, Department of Medicine Tufts University School of Medicine Chief, Division of Geographic Medicine and Infectious Diseases New England Medical Center George S. Kobayashi, Ph.D. Professor, Departments of Microbiology and Immunology and Internal Medicine Washington University School of Medicine J. Michael Koomey, Ph.D. Associate Professor, Department of Microbiology and Immunology University of Michigan Medical School Donald J. Krogstad, M.D. Henderson Professor and Chair, Department of Tropical Medicine School of Public Health and Tropical Medicine Tulane University David W. Lazinski, Ph.D. Assistant Professor, Department of Molecular Biology and Microbiology Tufts University School of Medicine John M. Leong, M.D., Ph.D. Assistant Professor, Department of Microbiology University of Massachusetts Medical School Zell A. McGee, M.D. Professor, Departments of Internal Medicine and Pathology University of Utah School of Medicine Gerald Medoff, M.D. Professor, Departments of Microbiology and Immunology and Internal Medicine Washington University School of Medicine Cody H. Meissner, M.D. Professor, Department of Pediatrics Chief, Division of Infectious Diseases New England Medical Center Associate Professor, Department of Pediatrics Tufts University School of Medicine Richard M. Peek, Jr. Assistant Professor, Department of Medicine Division of Gastroenterology, Department of Medicine Vanderbilt University School of Medicine Andrew Plaut, M.D. Professor Division of Gastroenterology, Department of Medicine Tufts University School of Medicine William G. Powderly, M.D. Associate Professor and Co-director Infectious Diseases Division, Department of Internal Medicine Washington University School of Medicine Jane E. Raulston, Ph.D. Research Assistant Professor Department of Microbiology and Immunology University of North Carolina School of Medicine Edward N. Robinson, Jr., M.D. Department of Medicine University of North Carolina The Moses H. Cone Memorial Hospital Moselio Schaechter, Ph.D. Distinguished Professor, Emeritus Tufts University School of Medicine Boston, Massachusetts Adjunct Professor San Diego State University David Schlessinger, Ph.D. Professor, Department of Molecular Microbiology Washington University School of Medicine Arnold L. Smith, M.D. Professor and Chairman, Department of Molecular Microbiology and Immunology University of Missouri School of Medicine David R. Snydman, M.D. Professor, Departments of Medicine and Pathology Tufts University School of Medicine Director, Clinical Microbiology New England Medical Center John K. Spitznagel, M.D. Professor and Former Chairman, Department of Microbiology and Immunology Emory University School of Medicine Allen C. Steere, M.D. Professor, Department of Medicine Tufts University School of Medicine Chief, Division of Rheumatology New England Medical Center Gregory A. Storch, M.D. Professor, Departments of Pediatrics and Medicine Washington University School of Medicine Stephen E. Straus, M.D. Chief, Laboratory of Clinical Investigation National Institutes of Health National Institute of Allergy and Infectious Diseases Francis P. Tally, M.D. Vice President, Research and Development Cubist Pharmaceuticals, Inc. Donald M. Thea, M.D. Department of Medicine Tufts University School of Medicine Chief, Division of Geographic Medicine and Infectious Diseases New England Medical Center Debbie S. Toder, M.D. Assistant Professor, Department of Pediatrics University of Rochester Medical Center David H. Walker, M.D. Professor and Chairman, Department of Pathology University of Texas Medical Branch at Galveston Ellen Whitnak, M.D. Professor, Department of Medicine University of Tennessee College of Medicine Chief, Infectious Diseases Section Veterans Affairs Medical Center Marion L. Woods, M.D. Assistant Professor Division of Infectious Diseases University of Utah Medical Center Priscilla B. Wyrick, Ph.D. Professor Department of Microbiology and Immunology University of North Carolina School of Medicine Victor L. Yu, M.D. Professor of Medicine University of Pittsburgh School of Medicine Chief, Infectious Diseases Service Veterans Affairs H. Kirk Ziegler, Ph.D. Professor, Department of Microbiology and Immunology Emory University School of Medicine

Table of Contents

SECTION I Principles	3	(126)
1 Establishment of Infectious Diseases	3	(8)
MOSELIO SCHAECHTER
BARRY I. EISENSTEIN
2 Normal Microbial Flora	11	(7)
BARRY I. EISENSTEIN
MOSELIO SCHAECHTER
3 Biology of Infectious Agents	18	(21)
MOSELIO SCHAECHTER
4 Genetics of Bacterial Pathogenesis	39	(13)
MOSELIO SCHAECHTER
BARRY I. EISENSTEIN
N. CARY ENGLEBERG
5 Biological Basis for Antibacterial Action	52	(10)
DAVID SCHLESSINGER
BARRY I. EISENSTEIN
6 Constitutive Defenses of the Body	62	(16)
JOHN K. SPITZNAGEL
7 Induced Defenses of the Body	78	(28)
H. KIRK ZIEGLER
8 The Parasite's Way of Life	106	(9)
MOSELIO SCHAECHTER
BARRY I. EISENSTEIN
N. CARY ENGLEBERG
9 Damage by Microbial Agents	115	(14)
MOSELIO SCHAECHTER
SECTION II Infectious Agents	129	(374)
Bacteria
10 Introduction to the Pathogenic Bacteria	129	(6)
MOSELIO SCHAECHTER
11 Staphylococci: Abscesses and Other Diseases	135	(8)
FRANCIS P. TALLY
Paradigm Author: Editors
12 Streptococci	143	(10)
ELLEN WHITNAK
NEIL L. BARG
13 Pneumococcus and Bacterial Pneumonia	153	(8)
GREGORY A. STORCH
Paradigm Author: Editors
14 Neisseriae: Gonococcus and Meningococcus	161	(9)
PENELOPE J. HITCHCOCK
EDWARD N. ROBINSON, JR.
ZELL A. MCGEE
Paradigm Author: J. Michael Koomey
15 Bacteroides and Abscesses	170	(6)
FRANCIS P. TALLY
16 Enteric Bacteria: "Secretory" (Watery) Diarrhea	176	(9)
GERALD T. KEUSCH
DAVID W.K. ACHESON
17 Invasive and Tissue-damaging Enteric Bacterial Pathogens: Bloody Diarrhea and Dysentery	185	(14)
GERALD T. KEUSCH
DAVID W.K. ACHESON
Paradigm Author: Victor J. DiRita
18 Pseudomonas aeruginosa: Ubiquitous Pathogen	199	(6)
DEBBIE S. TODER
19 Bordetella pertussis and Whooping Cough	205	(7)
ARNOLD L. SMITH
Paradigm Author: Victor J. DiRita
20 Clostridia	212	(5)
SHERWOOD L. GORBACH
21 Legionella: Parasite of Cells	217	(7)
N. CARY ENGLEBERG
Paradigm Author: N. Cary Engleberg
22 Helicobacter pylori: Pathogenesis of a "Slow" Bacterial Infection	224	(6)
RICHARD M. PEEK, JR.
MARTIN J. BLASER
23 Mycobacteria: Tuberculosis and Leprosy	230	(13)
JOHN K. SPITZNAGEL
24 Syphilis: A Disease with a History	243	(8)
EDWARD N. ROBINSON, JR.
PENELOPE J. HITCHCOCK
ZELL A. MCGEE
25 Lyme Disease	251	(6)
ALLEN C. STEERE
JOHN M. LEONG
26 Cat Scratch Disease, Bacillary Angiomatosis, and Other Bartonelloses	257	(4)
DAVID H. WALKER
Paradigm Author: N. Cary Engleberg
27 Chlamydiae: Genital, Ocular, and Respiratory Pathogens	261	(7)
PRISCILLA B. WYRICK
JANE E. RAULSTON
28 Rocky Mountain Spotted Fever and Other Rickettsioses	268	(7)
DAVID H. WALKER
29 Mycoplasma: Curiosity and Pathogen	275	(4)
GREGORY A. STORCH
30 Strategies to Combat Bacterial Infections	279	(7)
FRANCIS P. TALLY
Review of the Main Pathogenic Bacteria	286	(3)
Viruses
31 Biology of Viruses	289	(16)
BERNARD N. FIELDS
32 Picornaviruses: Polio Virus, Other Enteroviruses, and the Rhinoviruses	305	(10)
CODY MEISSNER
GREGORY A. STORCH
33 Arthropod-borne Viruses	315	(6)
CODY MEISSNER
Paradigm Author: N. Cary Engleberg
34 Paramyxoviruses: Measles, Mumps, Slow Viruses, and the Respiratory Syncytial Virus	321	(9)
STEPHEN E. STRAUS
GREGORY A. STORCH
35 Rabies	330	(6)
GEORGE M. BAER
Paradigm Author: Moselio Schaechter
36 Influenza and Its Virus	336	(9)
STEPHEN E. STRAUS
Paradigm Author: Moselio Schaechter
37 Rotaviruses and Other Viral Agents of Gastroenteritis	345	(5)
CODY MEISSNER
38 The Human Retroviruses: AIDS and Other Diseases	350	(14)
CODY MEISSNER
JOHN M. COFFIN
Paradigm Author: N. Cary Engleberg
39 Adenoviruses	364	(9)
GARY KETNER
Paradigm Author: Gary Ketner
40 Warts	373	(7)
ELLIOT J. ANDROPHY
Paradigm Author: Elliot J. Androphy
41 Herpes Simplex Virus and Its Relatives	380	(11)
STEPHEN E. STRAUS
Paradigm Author: Daniel K. Braun
42 Viral Hepatitis	391	(12)
DAVID W. LAZINSKI
Paradigm Author: David W. Lazinski
43 Strategies to Combat Viral Infections	403	(9)
STEPHEN E. STRAUS
44 Vaccines and Antisera in the Prevention and Treatment of Infection	412	(6)
SHERWOOD L. GORBACH
Review of the Main Pathogenic Viruses	418	(1)
Fungi
45 Introduction to the Fungi and the Mycoses	419	(7)
GEORGE S. KOBAYASHI
GERALD MEDOFF
46 Systemic Mycoses Caused by Primary Pathogens	426	(5)
GERALD MEDOFF
GEORGE E. KOBAYASHI
47 Systemic Mycoses Caused by Opportunistic Fungi	431	(4)
GERALD MEDOFF
GEORGE S. KOBAYASHI
48 Subcutaneous, Cutaneous, and Superficial Mycoses	435	(4)
GERALD MEDOFF
GEORGE S. KOBAYASHI
Review of the Medically Important Fungi	439	(1)
Animal Parasites
49 Introduction to Parasitology	440	(8)
DONALD J. KROGSTAD
N. CARY ENGLEBERG
50 Blood and Tissue Protozoa	448	(15)
DONALD J. KROGSTAD
N. CARY ENGLEBERG
51 Intestinal and Vaginal Protozoa	463	(8)
DONALD J. KROGSTAD
N. CARY ENGLEBERG
52 Intestinal Helminths	471	(9)
DONALD J. KROGSTAD
N. CARY ENGLEBERG
53 Tissue and Blood Helminths	480	(11)
DONALD J. KROGSTAD
N. CARY ENGLEBERG
54 Addressing Emerging Infectious Diseases	491	(12)
JAMES M. HUGHES
SECTION III Pathophysiology of Infectious Diseases	503	(166)
55 Diagnostic Principles	503	(10)
N. CARY ENGLEBERG
56 Principles of Epidemiology	513	(6)
DAVID R. SNYDMAN
57 Digestive System	519	(16)
GERALD T. KEUSCH
DAVID W.K. ACHESON
58 Central Nervous System	535	(14)
ARNOLD L. SMITH
59 Respiratory System	549	(15)
GREGORY A. STORCH
60 Urinary Tract	564	(9)
MICHAEL BARZA
61 Skin and Soft Tissue	573	(9)
FRANCIS P. TALLY
62 Bone, Joints, and Infections of Muscles	582	(7)
GERALD MEDOFF
63 Sepsis	589	(7)
ELLEN WHITNACK
64 Intravascular Infection	596	(8)
A.W. KARCHMER
65 Head and Neck Infections	604	(7)
ARNOLD L. SMITH
66 Sexually Transmitted Diseases	611	(10)
PENELOPE J. HITCHCOCK
67 Infections of the Compromised Patient	621	(5)
WILLIAM G. POWDERLY
68 Acquired Immunodeficiency Syndrome	626	(10)
WILLIAM G. POWDERLY
69 Congential and Neonatal Infections	636	(7)
JANET R. GILSDORF
ROGER G. FAIX
70 Zoonoses	643	(8)
VICTOR L. YU
71 Fever: A Clinical Sign of Infection	651	(5)
SUZANNE F. BRADLEY
72 Nosocomial and Latrogenic Infections	656	(5)
DAVID R. SNYDMAN
73 Food-borne Diseases	661	(8)
DAVID R. SNYDMAN
Answers to Self-assessment Questions	669	(13)
Answers to Review Charts	682	(7)
Figure and Table Credits	689	(4)
Index	693