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9780470725412

Metformin - The Gold Standard : A Scientific Handbook

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  • ISBN13:

    9780470725412

  • ISBN10:

    0470725419

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2008-05-05
  • Publisher: Wiley
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Summary

Metformin may play in important role in the future in helping to prevent the development of diabetes: it is a strong candidate therapy for delaying the onset of the disease and potentially as part of a treatment programme to correct features of the metabolic syndrome.This book celebrates 50 years of research into metformin and its use in the treatment of diabetes. Metformin is still the drug of choice for managing patients with type 2 diabetes and all new drugs are tested in comparison with this, the gold standard. Comprising seven sections, addressing different aspects of research on metformin and its applications, this book is edited by a world class team of expert diabetologists and beautifully presented in two colour throughout. It also includes a bibliography of all papers published on metformin and a complete list of all authors on those papers.

Author Biography

Professor Clifford J Bailey PhD FRCP FRCPath, Head of Diabetes Research, School of Life and Health Sciences, Aston University, Birmingham, UK

 

Table of Contents

Preface
Editors
History and Heritage
Introduction
Galegine and antidiabetic plants
Discovery of metformin
Introduction of metformin into clinical practice: the French innovation
Metformin: a chemical perspective
Pharmaceutical development of metformin
Efficacy
Introduction
Defining the clinical utility of metformin: reflections from Scotland
Metformin in combination
Metformin in children and adolescents with type 2 diabetes
Dose-related antihyperglycaemic efficacy of metformin
Understanding the glucose-lowering actions of metformin
Focus on metformin and body weight
Insights into the effects of metformin on the lipid profile
Cardiovascular Benefits
Introduction
Metformin and cardiovascular protection: lessons from the UK Prospective Diabetes Study
Survival benefits of metformin in high-risk populations
Mechanisms of vascular protection with metformin
Health Outcomes
Introduction
Defining the health economic benefits of metformin
Impact of metformin on quality of life
Safety
Introduction
Tolerability of metformin
Measures to improve the gastrointestinal tolerability of metformin
Defining the risk of lactic acidosis
Defining patient populations not indicated for metformin
Guidelines
Introduction
The role of metformin in setting treatment standards within management guidelines
Future Indications
Introduction
The potential of metformin for diabetes prevention
The role of metformin in polycystic ovary syndrome and infertility
Potential of metformin in the management of insulin-resistant states
The potential of metformin for the treatment of neoplastic disease
Future role of metformin in healthcare therapy
The metformin 50-year roll of honour
Index
Table of Contents provided by Publisher. All Rights Reserved.

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