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Foreword to Parasitic Helminths: Targets, Screens, Drugs and Vaccines | p. v |
Preface | p. xi |
List of Contributors | p. xiii |
Targets | p. 1 |
Ligand-Gated Ion Channels as Targets for Anthelmintic Drugs: Past, Current, and Future Perspectives | p. 3 |
How Relevant is Caenorhabditis elegans as a Model for the Analysis of Parasitic Nematode Biology? | p. 23 |
Integrating and Mining Helminth Genomes to Discover and Prioritize Novel Therapeutic Targets | p. 43 |
Recent Progress in Transcriptomics of Key Gastrointestinal Nematodes of Animals - Fundamental Research Toward New Intervention Strategies | p. 61 |
Harnessing Genomic Technologies to Explore the Molecular Biology of Liver Flukes-Major Implications for Fundamental and Applied Research | p. 73 |
RNA Interference: A Potential Discovery Tool for Therapeutic Targets of Parasitic Nematodes | p. 89 |
RNA Interference as a Tool for Drug Discovery in Parasitic Flatworms | p. 205 |
Screens | p. 121 |
Mechanism-Based Screening Strategies for Anthelmintic Discovery | p. 123 |
Identification and Profiling of Nematicidal Compounds in Veterinary Parasitology | p. 135 |
Quantitative High-Content Screening-Based Drug Discovery against Helmintic Diseases | p. 159 |
Use of Rodent Models in the Discovery of Novel Anthelmintics | p. 181 |
To Kill a Mocking Worm: Strategies to Improve Caenorhabditis elegans as a Model System for use in Anthelmintic Discovery | p. 202 |
Drugs | p. 227 |
Anthelmintic Drugs: Tools and Shortcuts for the Long Road from Discovery to Product | p. 219 |
Antinematodal Drugs - Modes of Action and Resistance: And Worms Will Not Come to Thee (Shakespeare: Cymbeline: IV, ii) | p. 233 |
Drugs and Targets to Perturb the Symbiosis of Wolbachia and Filarial Nematodes | p. 252 |
Promise of Bacillus thuringiensis Crystal Proteins as Anthelmintics | p. 267 |
Monepantel: From Discovery to Mode of Action | p. 283 |
Discovery, Mode of Action, and Commercialization of Derquantel | p. 297 |
Praziquantel: Too Good to be Replaced? | p. 309 |
Drug Discovery for Trematodiases: Challenges and Progress | p. 323 |
Vaccines | p. 341 |
Barefoot thru' the Valley of Darkness: Preclinical Development of a Human Hookworm Vaccine | p. 343 |
Vaccines Linked to Chemotherapy: A New Approach to Control Helminth Infections | p. 357 |
Antifilarial Vaccine Development: Present and Future Approaches | p. 377 |
Proteases as Vaccines Against Gastrointestinal Nematode Parasites of Sheep and Cattle | p. 399 |
Schistosomiasis Vaccines - New Approaches to Antigen Discovery and Promising New Candidates | p. 422 |
Sml4 Schistosoma mansoni Fatty Acid-Binding Protein: Molecular Basis for an Antihelminth Vaccine | p. 435 |
Mechanisms of Immune Modulation by Fasciola hepatica: Importance for Vaccine Development and for Novel Immunotherapeutics | p. 452 |
Prospects for Immunoprophylaxis Against Fasciola hepatica(Liver Fluke) | p. 465 |
Vaccines Against Cestode Parasites | p. 485 |
Index | p. 505 |
Table of Contents provided by Ingram. All Rights Reserved. |
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