Preface | |
Introduction | |
What is Parkinson's disease? From pathophysiology to symptoms | |
Pathophysiology of Parkinson's disease | |
Dysfunctions of the main neuronal pathways in Parkinson's disease | |
An overview of neuronal systems affected in Parkinson's disease | |
Dopaminergic neurons | |
Non-dopaminergic neurons | |
Consequences of dopaminergic neuronal lesions on basal ganglia circuits | |
The dopaminergic nigrostriatal system: pre- and postsynaptic compensatory mechanisms | |
Pathologic alterations of nigrostriatal circuits in Parkinson's disease | |
Histopathology of Parkinson's disease | |
The etiopathogenesis of Parkinson's disease | |
The genetics of Parkinson's disease: any clues for the sporadic forms? | |
Relevant environmental factors: focus on mitochondria | |
Mechanisms of cell death in Parkinson's disease: therapeutic implications | |
Conclusions | |
Parkinson's disease or Parkinson's syndromes? | |
What Parkinson's disease is not | |
Clinical features of Parkinson's disease | |
Motor symptoms | |
Non-motor symptoms | |
epression | |
pathy | |
ognitive impairment | |
leep | |
utonomic dysfunction | |
ensory symptoms | |
The different forms of Parkinson's disease: relevance for prognosis | |
The differential diagnosis of Parkinson's disease | |
Treatment-related symptoms | |
Motor complications | |
Non-motor complications | |
Treatment of Parkinson's disease | |
Antiparkinsonian agents | |
Levodopa | |
COMT inhibitors | |
Dopamine agonists | |
Monoamine oxidase B inhibitors | |
Other drugs | |
Medical management | |
Initiation of treatment | |
Maintenance of treatment (Fig. 2.7) | |
Motor complications | |
Management of non-motor complications | |
Non-medical management | |
Surgery | |
Destructive lesions | |
Cell therapy | |
Growth factors | |
Neuroprotection | |
MAO-B inhibitors | |
Dopamine agonists | |
Coenzyme Q | |
Creatine | |
Antiapoptotic drugs | |
Conclusion | |
Case studies | |
Case studies-diagnostic index | |
Index | |
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