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9780470074749

Cancer Vaccines and Tumor Immunity

by ; ;
  • ISBN13:

    9780470074749

  • ISBN10:

    0470074744

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2008-02-08
  • Publisher: Wiley-Liss

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Summary

Cancer Vaccines and Tumor Immunity offers a review of the basic scientific discoveries that have moved forward into clinical trials. Presented in the context of real-world human research and experimentation, these major scientific advances demonstrate how our understanding of immune activation, T-regulatory cells, and autoimmunity will impact cancer vaccine design. The authors also explain how vaccination in the context of bone marrow transplantation will open new avenues for clinical study in the future.

Author Biography

Rimas J. Orentas, PhD, is Associate Professor in the Department of Pediatrics, Section of Hematology-Oncology, and holds joint appointments in the Departments of Medicine and Microbiology and Molecular Genetics at the Medical College of Wisconsin in Milwaukee, Wisconsin.

James W. Hodge, PhD, is a Senior Scientist in the Laboratory of Tumor Immunology and Biology at the National Cancer Institute in Bethesda, Maryland.

Bryon D. Johnson, PhD, is Associate Professor in the Department ofPediatrics, Section of Hematology-Oncology at the Medical College of Wisconsin in Milwaukee, Wisconsin.

Table of Contents

Contributorsp. ix
Foreword: Cancer Vaccines and Cancer Immunotherapy: A New Paradigmp. xiii
Introduction
Cancer Vaccines: Progress and Promisep. 3
Adjuvant Therapy: Enhancing the Endogenous Immune Response
Fully Synthetic Carboyhydrate-Based Antitumor Vaccinesp. 15
Bacillus Calmette-Guerin Immunotherapy of Genitourinary Cancerp. 29
Stimulation of Toll-Like Receptor 9 for Enhancing Vaccinationp. 43
Antigen-Specific Therapy: Novel Presentation of Peptide and Protein Antigens
Polyepitope Vaccinesp. 69
Antigen-Specific Cancer Immunotherapy: HPV-Associated Cervical Cancer as a Model Systemp. 79
Poxviral Vectors for Cancer Vaccines: State of the Artp. 95
Immunotherapeutic Strategies Against Cancer Using Listeria monocytogenes as a Vector for Tumor Antigensp. 113
Coupling Innate and Adaptive Immunity with Yeast-Based Cancer Immunotherapyp. 131
Cell-Based Therapy: Using Cancer Cells as a Means to Induce Specific Tumor Immunity
Allogeneic Whole-Cell Vaccinesp. 153
Jump-Starting Tumor Immunity with Breast Cancer Therapeuticsp. 169
T-Regulatory Cell Manipulation in Tumor Immunotherapyp. 189
Tumor Vaccination After Autologous HSCT: What Has Been Learned from Experimental Modelsp. 205
Vaccines in the Setting of Hematopoietic Stem Cell Transplantationp. 217
Intratumor Generation of Vigorous Antitumor Immune Responsesp. 229
Cancer Immunotherapy: Untapping the Potential of Costimulatory Molecules Beyond CTLA-4p. 243
Defining Effective Clinical Responses
Advances in Immune Monitoring Strategies for Cancer Vaccines and Immunotherapyp. 271
Immune Evaluation of Cancer Vaccinesp. 291
Indexp. 309
Table of Contents provided by Ingram. All Rights Reserved.

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