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| Preface | p. xi |
| Main Theme of Current Aging Research | |
| Aging: Overview | p. 1 |
| Protein Oxidation in Aging and Age-Related Diseases | p. 22 |
| Stress Resistance by Caloric Restriction for Longevity | p. 39 |
| Biomedical Changes Associated with Aging | |
| Protein Glycation: Creation of Catalytic Sites for Free Radical Generation | p. 48 |
| Implications of Protein Degradation in Aging | p. 54 |
| Transglutaminase-Mediated Crosslinking of Specific Core Histone Subunits and Cellular Senescence | p. 65 |
| Proteome and Proteomics for the Research on Protein Alterations in Aging | p. 71 |
| Attenuation of EGF Signaling in Senescent Cells by Caveolin | p. 79 |
| Genomic Instability in Aging | |
| BRCA1 Gene Sequence Variation in Centenarians | p. 85 |
| Increases of Mitochondrial Mass and Mitochondrial Genome in Association with Enhanced Oxidative Stress in Human Cells Harboring 4,977 BP-Deleted Mitochondrial DNA | p. 97 |
| DNA Polymerase-[beta] May Be the Main Player for Defective DNA Repair in Aging Rat Neurons | p. 113 |
| Premature Aging and Predisposition to Cancers Caused by Mutations in RecQ Family Helicases | p. 121 |
| Health Span and Life Span in Transgenic Mice with Modulated DNA Repair | p. 132 |
| Cellular Maintenance and Stress Response | |
| Inhibition Mechanisms of Bioflavonoids Extracted from the Bark of Pinus maritima on the Expression of Proinflammatory Cytokines | p. 141 |
| Gene Expression and Regulation in the Extended Longevity Phenotypes of Drosophila | p. 157 |
| Impairment of Learning and Memory in Rats Caused by Oxidative Stress and Aging, and Changes in Antioxidative Defense Systems | p. 168 |
| Translocational Inefficiency of Intracellular Proteins in Senescence of Human Diploid Fibroblasts | p. 176 |
| Oxidative Stress and Neurodegeneration in Prion Diseases | p. 182 |
| On the True Role of Oxygen Free Radicals in the Living State, Aging, and Degenerative Disorders | p. 187 |
| Cellular and Molecular Pathogenic Mechanisms of Insulin-Dependent Diabetes Mellitus | p. 200 |
| Practical Approach for Functional Longevity | |
| Capacity for Recovery and Possible Mechanisms in Immobilization Atrophy of Young and Old Animals | p. 212 |
| Nutrition Interventions in Aging and Age-Associated Disease | p. 226 |
| Exercise at Old Age: Does It Increase or Alleviate Oxidative Stress? | p. 236 |
| Do Antioxidant Strategies Work against Aging and Age-associated Disorders? Propargylamines: A Possible Antioxidant Strategy | p. 248 |
| Antioxidant and Immunostimulating Activities of the Fruiting Bodies of Paecilomyces japonica, a New Type of Cordyceps sp | p. 261 |
| A New Function of Green Tea: Prevention of Lifestyle-related Diseases | p. 274 |
| Anti-aging and Health-promoting Constituents Derived from Traditional Oriental Herbal Remedies: Information Retrieval Using the TradiMed 2000 DB | p. 281 |
| Calorie Restriction and Longevity | |
| Caloric Restriction in Primates | p. 287 |
| Calorie Restriction Enhances the Expression of Key Metabolic Enzymes Associated with Protein Renewal during Aging | p. 296 |
| Caloric Restriction in Primates and Relevance to Humans | p. 305 |
| Aging and Caloric Restriction in Nonhuman Primates: Behavioral and in Vivo Brain Imaging Studies | p. 316 |
| The Inflammation Hypothesis of Aging: Molecular Modulation by Calorie Restriction | p. 327 |
| Panel Discussion: Perspectives in Aging Research in the New Millennium | p. 336 |
| Poster Papers | |
| A Thermolabile Variant of Methylenetetrahydrofolate Reductase Is a Determinant of Hyperhomocyst(e)inemia in the Elderly | p. 344 |
| Age-related Increase in the Expression of Heat-Shock Protein Genes in the Tissues of Unstressed Rats | p. 345 |
| Amyloid-[beta]-Peptide 25-35 Fragment Modulates the Expression of the Mitochondrial Cytochrome Oxidase Gene | p. 346 |
| Analysis of the Cell Distribution of Endogenous Murine Leukemia Virus in the Brains of SAMR1 and SAMP8 Mice | p. 347 |
| Analysis of Traditional Korean Food Patterns According to the Healthy Longevity Diet Based on the Database of Favorite Korean Foods | p. 348 |
| Analysis of Proteins in Aged Rat Kidney: The Effect of Calorie Restriction | p. 349 |
| Analysis of Redox Status in Serum during Aging | p. 350 |
| Animal Model for Alzheimer's Disease by PS2 Gene Transfer | p. 351 |
| Changes in Growth Factor-induced Signal Transduction during the Aging Process of Human Primary Fibroblasts | p. 352 |
| Contribution of Cyclooxygenase to Age-related Oxidative Stress | p. 353 |
| Control of Mitochondrial Redox Balance by the Mitochondrial NADP[superscript +]-dependent Isocitrate Dehydrogenase | p. 354 |
| The Pro- and Antioxidant Role of Glutathione in Selenite-induced Oxidative Stress and Apoptosis | p. 355 |
| Effects of Aging on Aldosterone Secretion in Rat Zona Glomerulosa Cells | p. 356 |
| Evidence for Differential Structure and Function of Hsp70 Family Members, Mot-1 and Mot-2, in Control of Cellular Senescence | p. 357 |
| Expression of Growth-Related Genes in the Tissues of Aged Rat Brain | p. 358 |
| Expression of Peroxiredoxin in the Skin and Change of Peroxiredoxin by Ultraviolet B Irradiation: A Possible Antioxidant Role against Oxidative Stress in the Skin | p. 359 |
| Genetic Polymorphism of Presenilin-1 Gene and Apolipoprotein E in Korean Elderly with Dementia | p. 361 |
| Impact of Growth Hormone Suppression in the Aging Process and Preliminary Longevity Analysis | p. 362 |
| Increased Expression of Calsenilin in the Brains of Scrapie-infected Mice | p. 363 |
| Induction of Cellular Senescence in Cervical Cancer Cells by Inhibition of HPV Oncogene Expression | p. 364 |
| Induction of Senescence-like Phenotype by an Alkylating Agent, Methyl Methanesulfonante, in Human Diploid Fibroblast | p. 365 |
| Investigation on Natural Peroxynitrite Scavengers | p. 366 |
| Involvement of Caspases in Cell Death Induced by Selenium Compounds in HL-60 Cells | p. 367 |
| Lowered 8-Hydroxyguanine Glycosylase Activity in Senescence-accelerated Mice due to a Single-base Mutation | p. 368 |
| Melatonin-related Compounds Have High Free Radical Scavenging Activity | p. 369 |
| Metabolic Modulation of Cellular Redox Potential Can Improve Cardiac Recovery from Ischemia-Reperfusion Injury | p. 370 |
| New Directions in Communicating Better Nutrition to Older Adults | p. 371 |
| Nitric Oxide Is Implicated in Apoptotic Cell Death Induced by H[subscript 2]O[subscript 2] in C6 Cells | p. 372 |
| Overexpression of Calsenilin in Sporadic Alzheimer's Disease Brain | p. 373 |
| Oxidative Stress Associated Antioxidant Enzyme and Neuroendocrine Markers in Dementia | p. 374 |
| p38 Mitogen-activated Protein Kinase Is Involved in H[subscript 2]O[subscript 2]-induced Phospholipase D Activation in Vascular Smooth Muscle Cells | p. 376 |
| Photoaging in Asian Skin: New Grading System and the Influence of Environmental Factors | p. 377 |
| Plasma Concentrations of an Endogenous Nitric Oxide Synthase Inhibitor, N[superscript G],N[superscript G]-Dimethylarginine: A Novel Risk Factor for Cerebral Infarction in the Elderly | p. 378 |
| Protection of Mitochondria Permeability Transition by Dihydroxybenzaldehyde against Hydroxyl Radicals | p. 379 |
| Risk Factors for Total Mortality in Centenarians in Aichi Prefecture, Japan | p. 380 |
| The Activation Mechanisms of NF-[kappa]B and Inflammatory Enzymes during Aging | p. 381 |
| Vitamin and Mineral Supplement Use among Independent-living Korean and American Older Adults | p. 382 |
| Vitamin D and Estrogen Receptor Gene Polymorphism and Their Interaction Associated with Bone Mineral Density in Korean Postmenopausal Women | p. 384 |
| Vitamin-E Dose-Associated Alterations in Mouse Immune Function | p. 385 |
| Index of Contributors | p. 387 |
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