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9781402000683

Relaxin 2000

by ;
  • ISBN13:

    9781402000683

  • ISBN10:

    1402000685

  • Format: Hardcover
  • Copyright: 2001-12-01
  • Publisher: Kluwer Academic Pub
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Summary

This publication contains the proceedings of "Relaxin 2000: The Third International Conference on the Hormone Relaxin & Related Peptides", held on October 22-27, 2000, at the Cable Beach Resort, Broome, Australia. Delegates from academia and industry who attended this meeting, the latest in an irregular series, participated in an exciting scientific program that covered all aspects of current relaxin research, the growth of which in recent years has been stellar. Seminal topics presented at the conference and in this book include: clinical roles for relaxin, elucidation of novel sites of action of the hormone, relaxin-induced signal transduction, identification of non-pregnant roles of the hormone, and of novel relaxin-related peptides (particularly insl 3 and 5) and their possible synergistic actions with relaxin. Audience: This book will be of considerable interest to both endocrinologists and protein researchers, including those engaged in studies in members of the insulin super-family.

Table of Contents

Preface xiii
Relaxin 2000 Committees xv
Sponsors xvii
Young Investigators Awards xviii
In memoriam xix
Abbreviations xxi
Photo xxii
Section 1: Plenary Lecture
Hooked on relaxin: A career-long love affair with a fickle and elusive hormone
3(24)
B.G. Steinetz
Section 2: Reproductive Physiology of Relaxin I - Peripartum Period
Effects of relaxin on the cervix and the vagina in the rat
27(8)
O.D. Sherwood
S. Zhao
Relaxin retards apoptosis in the cervix and the vagina during pregnancy in rats
35(6)
S. Zhao
O.D. Sherwood
Synthesis and function of relaxin in human endometrium
41(6)
G. Weiss
S. Palejwala
L. Tseng
L.T. Goldsmith
Analysis of relaxin deficient mice
47(6)
L. Zhao
P.J. Roche
J. M. Gunnerson
C. Samuel
V. E. Hammond
F. Beck
E. M. Wintour
G. W. Tregear
Relaxin is a key regulatory peptide in the reproductive tract of the pregnant tammar wallaby, Macropus eugenii
53(6)
L.J. Parry
Characterization of preprorelaxin in a marsupial, the tammar wallaby, Macropus eugenii
59(6)
L.J. Parry
R. Ivell
Section 3: Reproductive Physiology of Relaxin II - Uterus and Implantation
Relaxin induces specific alterations in gene expression in the human endometrium
65(8)
E.N. Unemori
M. Lewis
B.H. Grove
U. Deshpande
Relaxin is an important factor for uterine differentiation and implantation in the marmoset monkey
73(10)
A. Einspanier
Relaxin and porcine uterine growth and remodeling
83(8)
J. Lenhart
K. Ohleth
P. Ryan
J. Wang-Lee
C. Bagnell
Relaxin and placental dysfunction in the horse
91(10)
P. Ryan
W. Vaala
K. Bennett-Wimbush
C. Bagnell
Intersection of the relaxin and estrogen signalling pathways in the uterus
101(8)
R.D. Koos
S.B. Pillai
Relaxin up-regulates rat uterine vascular endothelial growth factor mRNA in vivo
109(6)
S.B. Pillai
O.D. Sherwood
R.D. Koos
Comparative aspects of relaxin and relaxin-like factor (Insulin3) in the placental trophoblast
115(6)
T. Klonisch
S. Hombach-Klonisch
Secretion of matrix metalloproteinase-2 tissue inhibitor of metalloproteinase-1 and human chorionic gonadotropin by cytophoblastic cells: Is there regulation by relaxin?
121(6)
P. Mock
A. Meisser
M. Araman
C. Wuillemin
A. Campana
P. Bischof
Molecular remodelling of members of the relaxin family during primate evolution
127(2)
T. Klonisch
C. Froehlich
F. Tetens
B. Fischer
S. Hombach-Klonisch
Relaxin in the hamster
129(10)
R. Renegar
Section 4: Reproductive Physiology of Relaxin III - Ovary
Relaxin: a luteotrophic factor in the marmoset corpus luteum
139(6)
S. Verhagen
A. Einspanier
Isolation and bioactivity of relaxin from the tammar wallaby (Macropus eugenii)
145(2)
R.A.D. Bathgate
A. Siebel
A. Claasz
M. Macris
G.W. Tregear
L.J. Parry
Possible role of the insulin-like growth factor (ICF) family for the bovine ovarian function
147(2)
D. Schams
B. Berisha
W. Amselgruber
M. Kosmann
R. Einspanier
Identification of consensus sequences in the rat relaxin promoter which bind nuclear proteins
149(4)
P. Fu
J. Gunnersen
G.W. Tregear
P.J. Roche
Section 5: Cardiovascular Physiology of Relaxin
Effects of relaxin on experimentally-induced myocardial infarction. Is this hormone a natural shield against cardiovascular disease?
153(6)
M. Bigazzi
D. Bani
T. Bani Sacchi
Systemic relaxin administration stimulates angiogenic cytokine expression and vessel formation in a rat myocardial infarct model
159(10)
M. Lewis
U. Deshpande
L. Guzman
B. H. Grove
X. Huang
M.E. Erikson
L.B. Pickford
E.N. Unemori
Is relaxin the ``elusive'' vasodilator of pregnancy?
169(8)
K.P. Conrad
L.A. Danielson
J.N. Novak
L.J. Kerchner
R.E. Gandley
O.D. Sherwood
R.J. Ramirez
P.A. Moalli
Reproductive hormones and blood pressure during pregnancy
177(6)
P. Kristiansson
J.X. Wang
The effect of relaxin on vascular function in rat aorta
183(2)
J.J. Reid
N.-H. Tran
G.W. Tregear
P.J. Roche
Cardiovascular phenotypes of relaxin knockout mice: Importance of gender
185(6)
X-J. Du
L. Zhao
X-M. Gao
G.W. Tregear
Section 6: Physiology of Relaxin I - Brain
Relaxin action on and in the brain
191(10)
A.J.S. Summerlee
J.D. Silvertown
Neurons and neural pathways mediating the actions of circulating relaxin on the Brain
201(8)
M.J. McKinley
P. Burns
L. Colvill
M. Giles
P. Sinnayah
N. Sunn
B.J. Oldfield
R.S. Weisinger
Identification of relaxin and relaxin responsive cells in the rat brain
209(2)
T.C.D. Burazin
P.J. Davern
M.J. McKinley
G. W. Tregear
Effect of relaxin on the expression of angiotensin II receptors in the subfornical organ of rats during pregnancy
211(6)
A.J.S. Summerlee
R.S. Poterski
B.C. Wilson
Relaxin and relaxin receptors in brain
217(4)
Y-Y. Tan
G.W. Tregear
R.J. Summers
Section 7: Physiology of Relaxin II - Male
Relaxin knockout mice demonstrate delayed growth and have underdeveloped male reproductive tracts
221(4)
C.S. Samuel
E.P. Amento
Relaxin expression and binding in the rat prostate
225(6)
D.J. Hornsby
R.S. Poterski
A.J.S. Summerlee
Section 8: Preparation of Relaxin and Related Peptides
Chemical synthesis of relaxin analogues: Current status and future developments
231(6)
G.W. Tregear
M.N. Mathieu
N.F. Dawson
K.J. Smith
A.A. Claasz
A.B. Clippingdale
J.D. Wade
A new synthesis of human 2 relaxin using selective bridging
237(2)
H. Echner
F.P. Armbruster
W. Voelter
Nα-mono-biotinylated rat relaxin: synthesis and activity
239(2)
M.N. Mathieu
C.P. Bond
J.D. Wade
R.J. Summers
G.W. Tregear
Design, synthesis and biological activity of template-assembled peptide mimetics of rat relaxin
241(2)
M.N. Mathieu
J.D. Wade
Y-Y. Tan
R.J. Summers
G.W. Tregear
Chemical synthesis and relaxin activity of analogues of ovine insulin 3 containing specific B-chain residue replacements
243(4)
A.A. Claasz
R.A. Bathgate
N.F. Dawson
R.J. Summers
L. Otvos, Jr.
G.W. Tregear
J.D. Wade
Chemical synthesis and biological activity of ovine insulin 3, a relaxin structural homologue
247(2)
N.F. Dawson
M. Macris
R.J. Summers
Y-Y. Tan
G.W. Tregear
J.D. Wade
Solid phase synthesis of rat prorelaxin C-peptides (1-73) and (76-101)
249(2)
N.F. Dawson
Y-Y. Tan
R.J. Summers
M. Macris
L. Otvos, Jr.
G.W. Tregear
J.D. Wade
Chemical synthesis and relaxin activity of rat insulin 3
251(4)
K.J. Smith
R.A. Bathgate
A.A. Claasz
N.F. Dawson
L. Otvos, Jr.
G.W. Tregear
J.D. Wade
Section 9: Relaxin Bioassays
Structure-activity relationships of relaxin and relaxin-like factor/Insulin 3
255(6)
Y-Y. Tan
N.F. Dawson
A.R. Kompa
C. Bond
A. Claasz
J.D. Wade
G.W. Tregear
R.J. Summers
Relaxin bioasays
261(10)
M.E. Erikson
S-H. Liu
Bioassays for relaxin and relaxin-related peptides
271(2)
Y.Y. Tan
C. Bond
J.D. Wade
G.W. Tregear
R.J. Summers
A highly sensitive homologous human relaxin ELISA
273(6)
F.P. Armbruster
I. Maier
H-J. Gron
S.M. Bailer
T. Dschietzig
K. Stangl
H. Echner
T.H. Lippert
H. Seeger
W. Voelter
Section 10: Relaxin-induced Signal Transduction
Relaxin and scaffolding proteins in signalling crosstalk
279(6)
B.M. Sanborn
K.L. Dodge
C-Y. Ku
C. Yue
Mechanism of action of relaxin in human cervix
285(6)
L.T. Goldsmith
G. Weiss
S. Palejwala
Myometrial relaxant action of relaxin
291(10)
M. Hollingsworth
S. Rudkin
S. Downing
The use of biosensor technology to search for orphan biomolecules: towards the relaxin receptor
301(8)
E. Nice
B. Catimel
J. Rothacker
R.A.D. Bathgate
M. Mathieu
A.A. Claasz
G.W. Tregear
J.D. Wade
Relaxin signal transduction couples tyrosine phosphorylation to cAMP upregulation
309(8)
O. Bartsch
B. Bartlick
R. Ivell
Relaxin activating effect on the adenylyl cyclase and glycogen synthase in muscles of mammals and molluscs
317(4)
L. Kuznetsova
S. Plesneva
E. Omeljaniuk
A. Shpakov
M. Pertseva
The regulatory role of protein kinase C in insulin signal transduction via adenylyl cyclase signalling system
321(6)
S. Plesneva
A. Shpakov
L. Kuznetsova
M. Pertseva
Section 11: Relaxin-like Factors
The relaxin-like factor: from gene to physiology
327(10)
R. Ivell
M.R. Zarreh-Hoshyari-Khah
R.A.D. Bathgate
M. Balvers
P.J. Baker
P.J. O'Shaughnessy
Molecular genetics of insulin3
337(10)
S. Nef
S. Verma-Kurvari
T.E. Shipman
L.F. Parada
Testicular descent in rats: a role for relaxin?
347(2)
L.J. Parry
D.J. Hornsby
R.S. Poterski
B.C. Wilson
A.J.S. Summerlee
The relaxin-like factor (Insulin3) is highly expressed in the ruminant ovary: A putative ruminant relaxin?
349(8)
R.A.D. Bathgate
N. Moniac
B. Bartlick
A.A. Claasz
N.F. Dawson
Y-Y. Tan
J.D. Wade
G.W. Tregear
R. Ivell
Characterization of the rat relaxin like factor/jak3 gene region
357(2)
P.J. Roche
Z. Nasa
G. Tokhi
Relaxin-like factor is differentially expressed in the normal and neoplastic human mammary gland
359(2)
S. Hombach-Klonisch
J. Buchman
S. Sarun
B. Fischer
T. Klonisch
Relaxin-like factor in the human thyroid
361(2)
T. Klonisch
S. Hombach-Klonisch
B. Fischer
C. Hoang-Vu
The genomics of insulin 5
363(10)
S. Jaspers
S. Lok
C.E. Lofton-Day
B.A. Haldeman
T.E. Whitmore
K.P. Foley
D. Conklin
Section 12: Clinical Aspects of Relaxin I - Matrix Remodelling
Relaxin clinical trials in systemic sclerosis
373(10)
M.S. Erikson
E.N. Unemori
Relaxin decreases renal interstitial fibrosis: A novel treatment to slow the progression of kidney disease?
383(6)
S.L. Garber
Y. Mirochnik
C. Brecklin
L. Slobodskoy
E.N. Unemori
B.H. Grove
J.A.L. Arruda
G. Dunea
Relaxin modulates fibrillin-2, but not fibrillin-1, gene expression by human dermal fibroblasts
389(4)
C.S. Samuel
L.Y. Sakai
E.P. Amento
Effect of relaxin on normal and impaired wound healing in rodents
393(6)
X. Huang
G. Arnold
M. Lewis
L. Guzman
B.H. Grove
E.N. Unemori
K. Szebo
The formation of amyloid fibrils by relaxin
399(8)
C.E. MacPhee
C.M. Dobson
J.D. Wade
Section 13: Clinical Aspects of Relaxin II - Joints, Breast Cancer and Delivery
Pelvic girdle relaxation, developmental dysplasia of the hip and the hormone relaxin - are they loosely connected?
407(8)
A.H. MacLennan
Back pain in IVF-induced and spontaneous pregnancies
415(6)
P. Kristiansson
L. Nilsson-Wikmar
B. von Schoultz
K. Svardsudd
H. Wramsby
Immunohistochemical detection of relaxin binding to ligaments of the thumb and knee
421(4)
S. Galey
J. Lubahn
D. Ivance
E. Konieczko
C. Arnold
T. Cooney
Pre-term delivery predicted by serum relaxin
425(4)
I. Vogel
M. Glavind-Kristensen
J. Dalby Salvig
P. Thorsen
P. Sandager
N. Uldberg
High serum concentrations of relaxin correlate with dissemination of breast cancer
429(8)
C. Binder
L. Binder
L. Gurlit
A. Einspanier
Relationship of serum relaxin levels to knee joint laxity in female athletes
437(16)
C. Arnold
C. Van Bell
V. Rogers
T. Cooney
Section 14: Round Table Discussion - Relaxin and the New Millennium
Author Index 453(4)
Subject Index 457

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