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George P. Chrousos, MD, MACP, MACE, FRCP, is in the Unit of Endocrinology, Metabolism and Diabetes, First Department of Paediatrics, National University of Athens Medical School, Greece. He served as a Distinguished Visiting Scientist at the National Institute of Child Health and Human Development. He is among the most cited clinical investigators in the areas of Clinical Medicine, Biology and Biochemistry.
Gregory A. Kaltsas, MD, FRCP, teaches at the Division of Endocrinology, Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Greece.
Dedication to Samuel M. McCann | p. xiii |
Preface | p. xv |
An Overview of the Volume | p. xvi |
Introduction | |
Chronology of Advances in Neuroendocrine Immunomodulation | p. 1 |
The Mitochondrion as a Primary Site of Action of Regulatory Agents Involved in Neuroimmunomodulation | p. 12 |
Immunomodulatory Properties of Substance P: The Gastrointestinal System as a Model | p. 23 |
The Neuroendocrine Immune Basis for Autoimmune and Allergic Disorders | |
Hypothalamic-Pituitary-Adrenal Axis Function in Sjogren's Syndrome: Mechanisms of Neuroendocrine and Immune System Homeostasis | p. 41 |
The Role of Chaperone Proteins in Autoimmunity | p. 52 |
The Role of Stress in Asthma: Insight from Studies on the Effect of Acute and Chronic Stressors in Models of Airway Inflammation | p. 65 |
The Critical Role of Mast Cells in Allergy and Inflammation | p. 78 |
Immunomodulation: The Future Cure for Allergic Diseases | p. 100 |
Neural Correlates of IgE-Mediated Allergy | p. 116 |
Dialogue between the Brain and the Immune System in Inflammatory Arthritis | p. 132 |
Neuroimmunoendocrinology in Aging and Pain | |
Neurosteroids as Endogenous Inhibitors of Neuronal Cell Apoptosis in Aging | p. 139 |
Role of Thymulin or Its Analogue as a New Analgesic Molecule | p. 153 |
Therapeutic Management of Chronic Neuropathic Pain: An Examination of Pharmacologic Treatment | p. 164 |
Neural and Neuroendocrine Regulation of Dendritic Cell Function | |
Regulation of Dendritic Cell Differentiation by Vasoactive Intestinal Peptide: Therapeutic Applications on Autoimmunity and Transplantation | p. 187 |
Neuroendocrine Regulation of Skin Dendritic Cells | p. 195 |
PPAR[gamma], a Lipid-Activated Transcription Factor as a Regulator of Dendritic Cell Function | p. 207 |
Novel Functions of Cytokines in the Nervous System | |
Roles of Glia-Derived Cytokines on Neuronal Degeneration and Regeneration | p. 219 |
Brain Cytokines and the 5-HT System during Poly I:C-Induced Fatigue | p. 230 |
Participation of the Endocannabinoid System in the Effect of TNF-[alpha] on Hypothalamic Release of Gonadotropin-Releasing Hormone | p. 238 |
Neuroimmunomodulation in Chronic Infectious and Inflammatory Diseases | |
Low-Grade Inflammation in Chronic Infectious Diseases: Paradigm of Periodontal Infections | p. 251 |
Local Amplification of Glucocorticoids by 11[Beta]-Hydroxysteroid Dehydrogenase Type 1 and Its Role in the Inflammatory Response | p. 265 |
Immunoneuroendocrine Interactions in Chagas Disease | p. 274 |
Thymus-Dependent T Cell Tolerance of Neuroendocrine Functions: Principles, Reflections, and Implications for Tolerogenic/Negative Self-Vaccination | p. 284 |
The Adrenal Connection in Neuroimmunoendocrinology | |
Molecular Understanding of Cytokine-Steroid Hormone Dialogue: Implications for Human Diseases | p. 297 |
The Role of Toll-like Receptors in the Immune-Adrenal Crosstalk | p. 307 |
Adrenocortical Tumorigenesis | p. 319 |
Alpha 2-Adrenergic Receptors Decrease DNA Replication and Cell Proliferation and Induce Neurite Outgrowth in Transfected Rat Pheochromocytoma Cells | p. 335 |
Pheochromocytoma: Physiopathologic Implications and Diagnostic Evaluation | p. 346 |
The Stress System: Activators, Mediators, Effectors, and Counterregulators | |
Beyond Heart Rate Variability: Vagal Regulation of Allostatic Systems | p. 361 |
Interleukin-6: A Cytokine and/or a Major Modulator of the Response to Somatic Stress | p. 373 |
The Role of Stress in the Clinical Expression of Thyroid Autoimmunity | p. 382 |
Annexin 1, Glucocorticoids, and the Neuroendocrine-Immune Interface | p. 396 |
Index of Contributors | p. 411 |
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