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9781573316231

Neuroendocrine and Immune Crosstalk, Volume 1088

by ; ;
  • ISBN13:

    9781573316231

  • ISBN10:

    1573316237

  • Edition: 1st
  • Format: Paperback
  • Copyright: 2006-12-04
  • Publisher: Wiley-Blackwell

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Summary

Crosstalk between the neuroendocrine and immune systems plays an essential role in inflammatory, autoimmune, and allergic diseases. An international group of scientists from the fields of neurobiology, neuroendocrinology, immunology, and behavioral sciences reports here on recent advances in our understanding of the communication and modulation taking place between the neuroendocrine and immunological systems.In an effort to incorporate all recent knowledge in this field, broad aspects of endocrinology and neuropsychiatric and autoimmune disorders is included, with special attention given to recent progress in molecular biology and genetics.In particular, the volume focuses on diseases of the nervous system and their modulation by the immune and endocrine systems, as well as on the neuroimmunomodulation of inflammatory, autoimmune, and allergic diseases with an emphasis on the female gender.Special care has been taken by the editors to balance basic and clinical information. The volume is divided into sections: the cytokine and neuropeptide signal transduction systems and their immunomodulatory properties, the neuroendocrine immune basis of rheumatic disease, models of inflammation, the immunology of neuropsychiatric and allergic disorders, neuroendocrine and autoimmune adaptations in aging, neuroimmune interactions in chronic pain disorders and infectious diseases, and finally a structural and functional overview of the stress system.Clinical applications have been extrapolated from the basic knowledge and physiology of neuroimmune interactions, so this volume will provide a useful update for both researchers and clinicians.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

George P. Chrousos, MD, MACP, MACE, FRCP, is in the Unit of Endocrinology, Metabolism and Diabetes, First Department of Paediatrics, National University of Athens Medical School, Greece. He served as a Distinguished Visiting Scientist at the National Institute of Child Health and Human Development. He is among the most cited clinical investigators in the areas of Clinical Medicine, Biology and Biochemistry.

Gregory A. Kaltsas, MD, FRCP, teaches at the Division of Endocrinology, Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Greece.

Table of Contents

Dedication to Samuel M. McCannp. xiii
Prefacep. xv
An Overview of the Volumep. xvi
Introduction
Chronology of Advances in Neuroendocrine Immunomodulationp. 1
The Mitochondrion as a Primary Site of Action of Regulatory Agents Involved in Neuroimmunomodulationp. 12
Immunomodulatory Properties of Substance P: The Gastrointestinal System as a Modelp. 23
The Neuroendocrine Immune Basis for Autoimmune and Allergic Disorders
Hypothalamic-Pituitary-Adrenal Axis Function in Sjogren's Syndrome: Mechanisms of Neuroendocrine and Immune System Homeostasisp. 41
The Role of Chaperone Proteins in Autoimmunityp. 52
The Role of Stress in Asthma: Insight from Studies on the Effect of Acute and Chronic Stressors in Models of Airway Inflammationp. 65
The Critical Role of Mast Cells in Allergy and Inflammationp. 78
Immunomodulation: The Future Cure for Allergic Diseasesp. 100
Neural Correlates of IgE-Mediated Allergyp. 116
Dialogue between the Brain and the Immune System in Inflammatory Arthritisp. 132
Neuroimmunoendocrinology in Aging and Pain
Neurosteroids as Endogenous Inhibitors of Neuronal Cell Apoptosis in Agingp. 139
Role of Thymulin or Its Analogue as a New Analgesic Moleculep. 153
Therapeutic Management of Chronic Neuropathic Pain: An Examination of Pharmacologic Treatmentp. 164
Neural and Neuroendocrine Regulation of Dendritic Cell Function
Regulation of Dendritic Cell Differentiation by Vasoactive Intestinal Peptide: Therapeutic Applications on Autoimmunity and Transplantationp. 187
Neuroendocrine Regulation of Skin Dendritic Cellsp. 195
PPAR[gamma], a Lipid-Activated Transcription Factor as a Regulator of Dendritic Cell Functionp. 207
Novel Functions of Cytokines in the Nervous System
Roles of Glia-Derived Cytokines on Neuronal Degeneration and Regenerationp. 219
Brain Cytokines and the 5-HT System during Poly I:C-Induced Fatiguep. 230
Participation of the Endocannabinoid System in the Effect of TNF-[alpha] on Hypothalamic Release of Gonadotropin-Releasing Hormonep. 238
Neuroimmunomodulation in Chronic Infectious and Inflammatory Diseases
Low-Grade Inflammation in Chronic Infectious Diseases: Paradigm of Periodontal Infectionsp. 251
Local Amplification of Glucocorticoids by 11[Beta]-Hydroxysteroid Dehydrogenase Type 1 and Its Role in the Inflammatory Responsep. 265
Immunoneuroendocrine Interactions in Chagas Diseasep. 274
Thymus-Dependent T Cell Tolerance of Neuroendocrine Functions: Principles, Reflections, and Implications for Tolerogenic/Negative Self-Vaccinationp. 284
The Adrenal Connection in Neuroimmunoendocrinology
Molecular Understanding of Cytokine-Steroid Hormone Dialogue: Implications for Human Diseasesp. 297
The Role of Toll-like Receptors in the Immune-Adrenal Crosstalkp. 307
Adrenocortical Tumorigenesisp. 319
Alpha 2-Adrenergic Receptors Decrease DNA Replication and Cell Proliferation and Induce Neurite Outgrowth in Transfected Rat Pheochromocytoma Cellsp. 335
Pheochromocytoma: Physiopathologic Implications and Diagnostic Evaluationp. 346
The Stress System: Activators, Mediators, Effectors, and Counterregulators
Beyond Heart Rate Variability: Vagal Regulation of Allostatic Systemsp. 361
Interleukin-6: A Cytokine and/or a Major Modulator of the Response to Somatic Stressp. 373
The Role of Stress in the Clinical Expression of Thyroid Autoimmunityp. 382
Annexin 1, Glucocorticoids, and the Neuroendocrine-Immune Interfacep. 396
Index of Contributorsp. 411
Table of Contents provided by Ingram. All Rights Reserved.

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