9780387915838

(BIOS Scientific Publisher) Tufts Univ., Boston, MA. Reviews the concepts and theories that guide research on the control of cell proliferation and cancer, and asks the question 'What is the nature of the default state of all cells - quiescence or proliferation?' Proposes the adoption new premises of exploration in this area. For researchers. Softcover.

Abbreviations

viii

Preface

ix

Acknowledgements

xiii

PART 1

Cell proliferation: the background and the premises

1

(13)

Introduction

1

(1)

A brief history

2

(5)

Understanding the control of cell proliferation

7

(2)

The hierarchical organization of nature

9

(2)

Conclusions

11

(1)

References

12

(2)

Cell proliferation, cell nutrition and evolution

14

(17)

Evolutionary perspective on the control of cell proliferation

14

(6)

The role of nutrition on the control of cell proliferation

20

(6)

Conclusions

26

(1)

References

27

(4)

The experimental evaluation of cell proliferation

31

(10)

Introduction

31

(6)

Fitting data into working hypotheses

37

(1)

The use and misuse of tritiated thymidine incorporation data

38

(1)

Conclusions

39

(1)

References

40

(1)

Hypotheses for the control of cell proliferation

41

(19)

Historical perspective

41

(4)

Positive hypotheses

45

(7)

Negative hypotheses

52

(3)

Conclusions

55

(1)

References

55

(5)

Sex hormone-mediated control of cell proliferation

60

(18)

Introduction

60

(1)

Control of cell proliferation by estrogens

61

(1)

Hypotheses

62

(9)

Control of cell proliferation by androgens

71

(1)

Conclusions

72

(2)

References

74

(4)

Cell proliferation and tissue differentiation

78

(13)

The different meanings of `differentiation'

78

(1)

A hierarchical perspective

79

(1)

The elusive concept of stem cells

80

(1)

The hemopoietic stem cells

81

(3)

Proliferation of antibody-producing cells: a different perspective

84

(2)

Conclusions

86

(2)

References

88

(3)

PART 2

Introduction to carcinogenesis and neoplasia

91

(8)

If normal cells beget normal cells, and neoplastic cells beget neoplastic cells, what causes normal cells to become neoplastic?

93

(2)

Germ-line mutations and carcinogenesis

95

(1)

Somatic mutations, cell proliferation, cell death, and the `differentiation' hypotheses

96

(1)

Are carcinogenesis and neoplasia cellular or tissue-based phenomena?

97

(1)

References

98

(1)

The enormous complexity of cancer

99

(13)

Introduction

99

(2)

Hierarchical levels of complexity in cancer

101

(7)

Conclusions

108

(1)

References

109

(3)

Facts and fantasies in carcinogenesis

112

(22)

Introduction

112

(6)

Experimental carcinogenesis: the lessons missed

118

(1)

Foreign-body carcinogenesis

118

(2)

Physical carcinogenesis

120

(1)

Chemical carcinogenesis

120

(2)

Viral carcinogenesis. But . . . are viruses per se carcinogenic agents?

122

(3)

On the uniqueness of the neoplastic cell

125

(2)

Carcinogenesis in a flask

127

(1)

Conclusions

128

(2)

References

130

(4)

Epilogue. Moving toward the integration of cell proliferation, carcinogenesis, and neoplasia into biology

134

(11)

Ideology, silent assumptions, and operational definitions

135

(2)

The universality of proliferation as the default state of all cells

137

(2)

Forerunners of the tissue organization field hypothesis

139

(1)

On paradigm changes

139

(1)

An integrative approach of control of cell proliferation and carcinogenesis

140

(2)

The impact of our reassessment

142

(1)

And . . . finally

142

(1)

References

143

(2)

Index

145

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The Society of Cells: Cancer and Control of Cell Proliferation

0387915834

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